« Previous
Next »
Journal of Hepatology
Volume 39
, Pages 36-42
, 2003
Immunopathogenesis of hepatitis B
References
- . Non-cytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol. 2001;19:65–91
- . Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity. 1996;4:25–36
-
Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver.
Proc Natl Acad Sci USA. 1996;93:4589–4594
- . Hepatitis B virus RNA-binding proteins associated with cytokine-induced clearance of viral RNA from the liver of transgenic mice. J Virol. 1999;73:474–481
- . Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice. J Immunol. 1997;159:2001–2008
- . Subversion of the immune system by pathogens. Cell. 1994;76:323–332
- . Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J Exp Med. 2000;192:921–930
- . Inhibition of hepatitis B virus replication by activation of NKT cells does not require inflammatory cell recruitment to the liver. J Immunol. 2001;167:6701–6705
- . Activation of a non-classical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity. 2002;16:583–594
- . Natural killer cells in antiviral defense. Annu Rev Immunol. 1999;17:189–220
-
.
Autoreactivity by design: innate B and T lymphocytes.
Nat Rev. 2001;1:177–186
- . T cell function and migration. Two sides of the same coin. N Engl J Med. 2000;343:1020–1034
- . Dynamics of T lymphocyte responses: intermediates, effectors and memory cells. Science. 2000;290:92–97
- . Roles of αβ and γδ T cell subsets in viral immunity. Annu Rev Immunol. 1992;10:123–151
- . T cell-dependent B cell activation. Annu Rev Immunol. 1993;11:331–360
- . Viral clearance without destruction of infected cells during acute HBV infection. Science. 1999;284:825–829
- Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology. 2000;32:1117–1124
- Rapid resolution of duck hepatitis B virus infections occurs after massive hepatocellular involvement. J Virol. 1992;66:1377–1388
- Direct ex vivo analysis of hepatitis B virus-specific CD8+ T cells associated with the control of infection. Gastroenterology. 1999;117:1–13
- Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. J Immunol. 1990;145:3442–3449
-
Hepatitis B virus antigen-specific T-cell activation in patients with acute and chronic hepatitis.
Br J Hepatol. 1991;13:310–317
- Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen. J Clin Invest. 1991;88:214–222
- Predominant T helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology. 1997;25:1022–1027
-
.
Hepatitis B virus immunopathogenesis.
Ann Rev Immunol. 1995;13:29–60
- Long-lasting memory T cell responses following self-limited acute hepatitis. J Clin Invest. 1996;98:1185–1194
- . The hepatitis B virus persists for decades after patients’ recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med. 1996;2:1104–1108
- . Molecular anatomy of viral persistence. J Virol. 1991;65:6381–6386
- . Modulation of hepatitis B infection by intravenous application of an immunoglobulin preparation that contains antibodies to hepatitis B e and core antigens but not to hepatitis B surface antigen. J Virol. 1984;51:420–424
- . The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen. Science. 1986;234:1398–1401
- . Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy. Nature. 1997;386:88–91
- . Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy. Nature. 1997;386:91–94
-
.
Role of B cells in antigen presentation of the hepatitis B core.
Proc Natl Acad Sci USA. 1997;94:14648–14653
- Molecular basis for the interaction of the hepatitis B virus core antigen with the surface immunoglobulin receptor of naı̈ve B cells. J Virol. 2001;75:6367–6374
- . Cytotoxic T lymphocytes recognize an HLA A2 restricted epitope within the hepatitis B virus nucleocapsid antigen. J Exp Med. 1991;174:1565–1570
- HLA-A31 and HLA-Aw68 restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis. J Exp Med. 1993;177(3):751–762
- HLA-A2-restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. J Immunol. 1993;150:4659–4671
- Department of Molecular and Experimental Medicine. Scripps Research Instit. The cytotoxic T lymphocyte response to multiple hepatitis B polymerase epitopes during and after acute viral infection. J Exp Med. 1995;181:1047–1058
- Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. J Exp Med. 2002;195:1089–1101
- The role of virus-specific CD8+ cells in liver damage and viral control during persistent hepatitis B virus infection. J Exp Med. 2000;191:1269–1280
- Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. J Clin Invest. 1992;89:87–96
- . Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B. J Clin Invest. 1997;99:3025–3033
- . The serology of chronic hepatitis B infection revisited. J Clin Invest. 1993;91:2586–2595
- . Non-deletional T-cell receptor transgenic mice: model for the CD4+ T-cell repertoire in chronic hepatitis B virus infection. J Virol. 2000;74:7587–7599
-
HLA class I restricted cytotoxic T cells in acute viral hepatitis type B.
Proc Natl Acad Sci USA. 1991;88:10445
- Activation of a heterogeneous hepatitis B core and e antigen-specific CD4+ T cell-population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection. J Virol. 1995;69:3358–3368
- Differential antigen-processing pathways of the hepatitis B virus e and core proteins. Gastroenterology. 1999;116:650–657
-
.
Pre-core/core gene mutants of hepatitis B virus: pathogenetic implications.
In:
Rizzetto M, Purcel R, Gerin J, Verme G editor. Viral hepatitis and liver diseases. Turin: Edizioni Minerva Medica; 1997;p. 127–137
- . Functional characterization of cloned intrahepatic, hepatitis B virus nucleoprotein-specific helper T cell lines. J Immunol. 1987;139:539–544
- Intrahepatic, nucleocapsid antigen-specific T cells in chronic active hepatitis B. J Immunol. 1987;139:2050–2058
- . Recognition of hepatitis B envelope proteins by liver-infiltrating T lymphocytes in chronic HBV infection. J Immunol. 1989;143:2650–2655
- Selective expansion of cytotoxic T lymphocytes with a CD4+CD56+ surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with hepatitis B virus. J Immunol. 1994;152:3074–3087
- Different cytokine profiles of intrahepatic T cells in chronic hepatitis B and hepatitis C virus infections. Gastroenterology. 1997;112:193–199
- . Serology of acute exacerbation in chronic hepatitis B. Gastroenterology. 1993;105:1141–1151
-
.
Immune mechanisms of viral clearance and disease pathogenesis during viral hepatitis.
In:
Arias IM, Boyer JL, Chisari FV, Fausto N, Schachter D, Shafritz DA editor. The liver. Biology and pathobiology. Philadelphia: Lippincott Williams & Wilkins; 2001;p. 763–782
-
.
Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?.
Proc Natl Acad Sci USA. 1990;87:6599–6604
- . Chracterization of self-reactive T cells that evade tolerance in hepatitis B e antigen transgenic mice. Eur J Immunol. 1995;25:1663–1672
- Lamivudine treatment can restore T cell responsiveness in chronic hepatitis. J Clin Invest. 1998;102:968–975
- Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy. Hepatology. 2001;33:963–971
- . The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype. J Virol. 1997;71:2192–2201
- . The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: a mechanism for persistence. J Immunol. 1998;160:2013–2021
- . CTL access to tissue antigen is restricted in vivo. J Immunol. 1994 Jul 15;153(2):482–488
- Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J Exp Med. 1995;182:1223–1230
- . Fas ligand-induced apoptosis as a mechanism of immune privilege. Science. 1995;270:1189–1192
- Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T cell tolerance. Nat Med. 2000;6:1348–1354
- . Selective killing of hepatitis B envelope antigen-specific B cells by class I-restricted, exogenous antigen-specific T lymphocytes. Nature. 1990;315:258–260
- . Immunization with soluble hepatitis B virus surface protein elicits murine H-2 class I-restricted CD8+ cytotoxic T lymphocyte responses in vivo. J Immunol. 1994;152:1110–1119
- . Antibody and cytotoxic T-cell responses to soluble hepatitis B virus (HBV) S antigen in mice: implication for the pathogenesis of HBV-induced hepatitis. J Virol. 1994;68:1418–1425
- . Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope. J Exp Med. 1994;180:933–943
- Natural variants of cytotoxic epitopes are T cell receptor antagonists for anti-viral cytotoxic T cells. Nature. 1994;369:407–410
PII: S0168-8278(03)00137-5
doi: 10.1016/S0168-8278(03)00137-5
© 2003 European Association for the Study of the Liver. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of Hepatology
Volume 39
, Pages 36-42
, 2003
