Journal of Hepatology
Volume 41, Issue 3 , Pages 446-453 , September 2004

Donor age influences 10-year liver graft histology independently of hepatitis C virus infection

  • Kinan Rifai

      Affiliations

    • Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif Assistance Publique-Hôpitaux de Paris, Université Paris Sud, 12–14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France
    • ,
  • Mylène Sebagh

      Affiliations

    • Service d'Anatomo-Pathologie, Equipe Propre de l'Institut National de la Santé et de la Recherche Médicale 9941, Unité Propre de Recherche de l'Enseignement Supérieur 3541, Hôpital Paul Brousse, Villejuif Assistance Publique-Hôpitaux de Paris, Université Paris Sud, 12–14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France
    • ,
  • Vincent Karam

      Affiliations

    • Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif Assistance Publique-Hôpitaux de Paris, Université Paris Sud, 12–14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France
    • ,
  • Faouzi Saliba

      Affiliations

    • Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif Assistance Publique-Hôpitaux de Paris, Université Paris Sud, 12–14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France
    • ,
  • Daniel Azoulay

      Affiliations

    • Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif Assistance Publique-Hôpitaux de Paris, Université Paris Sud, 12–14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France
    • ,
  • René Adam

      Affiliations

    • Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif Assistance Publique-Hôpitaux de Paris, Université Paris Sud, 12–14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France
    • ,
  • Denis Castaing

      Affiliations

    • Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif Assistance Publique-Hôpitaux de Paris, Université Paris Sud, 12–14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France
    • ,
  • Henri Bismuth

      Affiliations

    • Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif Assistance Publique-Hôpitaux de Paris, Université Paris Sud, 12–14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France
    • ,
  • Michel Reynès

      Affiliations

    • Service d'Anatomo-Pathologie, Equipe Propre de l'Institut National de la Santé et de la Recherche Médicale 9941, Unité Propre de Recherche de l'Enseignement Supérieur 3541, Hôpital Paul Brousse, Villejuif Assistance Publique-Hôpitaux de Paris, Université Paris Sud, 12–14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France
    • ,
  • Didier Samuel

      Affiliations

    • Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif Assistance Publique-Hôpitaux de Paris, Université Paris Sud, 12–14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France
    • ,
  • Cyrille Féray

      Affiliations

    • Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif Assistance Publique-Hôpitaux de Paris, Université Paris Sud, 12–14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France
    • Corresponding Author InformationCorresponding author. Tel.: +33-1-4559-3028; fax: +33-1-4559-3857.

Received 16 January 2004 ,Revised 24 March 2004 ,Accepted 7 May 2004.

References 

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  24. Busquets J, Xiol X, Figueras J, Jaurrieta E, Torras J, Ramos E, et al. The impact of donor age on liver transplantation: influence of donor age on early liver function and on subsequent patient and graft survival. Transplantation. 2001;71:1765–1771
  25. Paradis V, Youssef N, Dargere D, Ba N, Bonvoust F, Deschatrette J, et al. Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. Hum Pathol. 2001;32:327–332
  26. Sakai Y, Zhong R, Garcia B, Zhu L, Wall WJ. Assessment of the longevity of the liver using a rat transplant model. Hepatology. 1997;25:421–425
  27. Lunz JG, Contruccci S, Ruppert K, Murase N, Fung JJ, Starzl TE, et al. Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs. Am J Pathol. 2001;158:1379–1390
  28. Deschenes M, Forbes C, Tchervenkov J, Barkun J, Metrakos P, Tector J, et al. Use of older donor livers is associated with more extensive ischemic damage on intraoperative biopsies during liver transplantation. Liver Transpl Surg. 1999;5:357–361

PII: S0168-8278(04)00274-0

doi: 10.1016/j.jhep.2004.05.013

Journal of Hepatology
Volume 41, Issue 3 , Pages 446-453 , September 2004

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