Journal of Hepatology
Volume 43, Issue 1 , Pages 67-71 , July 2005

Pilot study of interferon gamma for chronic hepatitis C

  • Alejandro Soza

      Affiliations

    • The Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    • ,
  • Theo Heller

      Affiliations

    • The Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    • ,
  • Marc Ghany

      Affiliations

    • The Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    • ,
  • Glen Lutchman

      Affiliations

    • The Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    • ,
  • T. Jake Liang

      Affiliations

    • The Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    • ,
  • June Germain

      Affiliations

    • Department of Transfusion Medicine, Warren G. Magnusen Clinical Center, National Institutes of Health, Bethesda, MD, USA
    • ,
  • Henry H. Hsu

      Affiliations

    • InterMune, Inc., Brisbane, CA, USA
    • ,
  • Yoon Park

      Affiliations

    • The Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    • ,
  • Jay H. Hoofnagle

      Affiliations

    • The Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    • Corresponding Author InformationCorresponding author. Address: Building 31, Room 9A27, 31 Center Drive, Bethesda, MD 20892, USA. Tel.: +1 301 496 1333; fax: +1 301 480 2680.

Received 4 January 2005 ,Revised 13 February 2005 ,Accepted 14 February 2005.

References 

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  17. Kumashiro R, Ide T, Sasaki M, Murashima S, Suzuki H, Hino T, et al. Interferon-gamma brings additive anti-viral environment when combined with interferon-alpha in patients with chronic hepatitis C. Hepatol Res. 2002;22:20–26
  18. Larkin J, Jin L, Farmen M, Venable D, Huang Y, Tan SL, et al. Synergistic antiviral activity of human interferon combinations in the hepatitis C virus replicon system. J Interferon Cytokine Res. 2003;23:247–257
  19. Okuse C, Rinaudo JA, Farrar K, Wells F, Korba BE. Enhancement of antiviral activity against hepatitis C virus in vitro by interferon combination therapy. Antiviral Res. 2005;65:23–34
  20. InterMune, Inc. InterMune announces results of exploratory phase II study of interferon gamma-1b in advanced liver fibrosis; 2004. www.intermune.com: Accesed Jan 2005.
  21. Soza A, Everhart JE, Ghany MG, Doo E, Heller T, Promrat K, et al. Neutropenia during combination therapy of interferon alfa and ribavirin for chronic hepatitis C. Hepatology. 2002;36:1273–1279
  22. Lutchman G, Hoofnagle JH. Viral kinetics in hepatitis C. Hepatology. 2003;37:1257–1259
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☆ The authors who have taken part in this study have declared that they do not have a relationship with the manufacturers of the drugs involved either in the past or present and did not receive funding from the manufacturers to carry out their research.

PII: S0168-8278(05)00253-9

doi: 10.1016/j.jhep.2005.02.023

Journal of Hepatology
Volume 43, Issue 1 , Pages 67-71 , July 2005

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