Journal of Hepatology
Volume 44, Issue 1 , Pages 68-75 , January 2006

A pilot approach for quantitative assessment of liver fibrosis using ultrasound: preliminary results in 79 cases

  • Hiroyuki Yamada

      Affiliations

    • Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 43 226 2083; fax: +81 43 226 2088.
  • ,
  • Masaaki Ebara

      Affiliations

    • Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan
  • ,
  • Tadashi Yamaguchi

      Affiliations

    • Department of Information and Image Sciences, Faculty of Engineering, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan
  • ,
  • Shinichirou Okabe

      Affiliations

    • Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan
  • ,
  • Hiroyuki Fukuda

      Affiliations

    • Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan
  • ,
  • Masaharu Yoshikawa

      Affiliations

    • Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan
  • ,
  • Takashi Kishimoto

      Affiliations

    • Molecular Pathology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan
  • ,
  • Hisahiro Matsubara

      Affiliations

    • Academic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan
  • ,
  • Hiroyuki Hachiya

      Affiliations

    • Research Center for Frontier Medical Engineering, Faculty of Engineering, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan
  • ,
  • Hiroshi Ishikura

      Affiliations

    • Molecular Pathology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan
  • ,
  • Hiromitsu Saisho

      Affiliations

    • Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan

Received 26 November 2004 ,Revised 17 August 2005 ,Accepted 18 August 2005.

References 

  1. Nord JH. Biopsy diagnosis of cirrhosis: blind percutaneous versus guided direct vision technique. A review. Gastrointest Endosc. 1982;28:102–104
  2. Bedossa P, Dargère D, Paradis V. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology. 2003;38:1449–1457
  3. Brunt EM. Grading and staging the histopathological lesions of chronic hepatitis: The Knodell histology activity index and beyond. Hepatology. 2000;31:241–246
  4. Hübscher SG. Histological grading and staging in chronic hepatitis: clinical applications and problems. J Hepatol. 1998;29:1015–1022
  5. Phal A, Behling C, Oliver D, Kilani M, Monson P, Hassanein T. Serum aminotransferase levels and platelet counts as predictors of degree of fibrosis in chronic hepatitis C virus infection. Am J Gastroenterol. 2001;96:3053–3055
  6. Pilette C, Rousselet MC, Bedossa P, Chappard D, Oberti F, Rifflet H, et al. Histopathological evaluation of liver fibrosis: quantitative image analysis vs semi-quantitative scores. J Hepatol. 1998;28:439–446
  7. Lu LG, Zeng MD, Wan MB, Li CZ, Mao YM, Zhou XQ, et al. Grading and staging of hepatic fibrosis, and its relationship with non invasive diagnostic parameters. World J Gastroenterol. 2003;9:2574–2578
  8. Wai CT, Greenson JK, Fontana RJ, Kalbfleisch JD, Marrero JA, Conjeevaram HS, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003;38:518–526
  9. Taura T, Nakamura K, Takashima S, Kaminou T, Yamada R, Shuto T, et al. Heterogeneity of hepatic parenchymal enhancement on computed tomography during arterial portography: quantitative analysis of correlation with severity of hepatic fibrosis. Hepatol Res. 2001;20:182–192
  10. Zuckerman E, Slobodin G, Sabo E, Yeshurun D, Naschitz JE, Groshar D. Quantitative liver-spleen scan using single photon emission computerized tomography (SPECT) for assessment of hepatic function in cirrhotic patients. J Hepatol. 2003;39:326–332
  11. Colli A, Fraquelli M, Andreoletti M, Marino B, Zuccoli E, Conte D. Severe liver fibrosis or cirrhosis: Accuracy of US for detection-Analysis of 300 cases. Radiology. 2003;227:89–94
  12. Aubé C, Oberti F, Krali N, Namour MA, Loisel D, Tanguy JY, et al. Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis. J Hepatol. 1999;30:472–478
  13. Badawi AM, Derbala AS, Youssef ABM. Fuzzy logic algorithm for quantitative tissue characterization of diffuse liver diseases from ultrasound images. Int J Med Inform. 1999;55:135–147
  14. Sandrin L, Fourquet B, Hasquenoph JM, Yon S, Fournier C, Mal F, et al. Transient elastography: A new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol. 2003;29:1705–1713
  15. Wang Y, Itou K, Taniguchi N, Toei H, Kawai F, Nakamura M, et al. Studies on tissue characterization by texture analysis with co-occurrence matrix method using ultrasonography and CT imaging. J Med Ultrasonics. 2002;29:211–223
  16. Yeh WC, Huang SW, Li PC. Liver fibrosis grade classification with B-mode ultrasound. Ultrasound Med Biol. 2003;29:1229–1235
  17. Hung CH, Lu SN, Wang JH, Lee CM, Chen TM, Tung HD, et al. Correlation between ultrasonographic and pathologic diagnoses of hepatitis B and C virus-related cirrhosis. J Gastroenterol. 2003;38:153–157
  18. Hirata M, Akbar SMF, Horiike N, Onji M. Noninvasive diagnosis of the degree of hepatic fibrosis using ultrasonography in patients with chronic liver disease due to hepatitis C virus. Eur J Clin Invest. 2001;31:528–535
  19. Oosterveld BJ, Thijssen JM, Hartman PC, Rosenbusch GJ. Detection of diffuse liver disease by quantitative echography: Dependence on A priori choice of parameters. Ultrasound Med Biol. 1993;19:21–25
  20. Zheng RQ, Wang QH, Lu MD, Xie SB, Ren J, Su ZZ. Liver fibrosis in chronic viral hepatitis: An ultrasonographic study. World J Gastroenterol. 2003;9:2484–2489
  21. Yeh WC, Li PC, Jeng YM, Hsu HC, Kuo PL, Li ML. Elastic modulus measurements of human liver and correlation with pathology. Ultrasound Med Biol. 2002;28:467–474
  22. Fukuda H, Ebara M, Kobayashi A, Sugiura N, Yoshikawa M, Saisho H, et al. An image analyzing system using an artificial neural network for evaluating the parenchymal echo pattern of cirrhotic liver and chronic hepatitis. IEEE Trans Biomed Eng. 1998;45:396–400
  23. Yamaguchi T, Hachiya H, Kamiyama N, Moriyasu F. Examination of the spatial correlation of statistics information in the ultrasonic echo from diseased liver. Jpn J Appl Phys. 2002;41:3585–3589
  24. Yamaguchi T, Hachiya H, Kamiyama N, Ikeda K, Moriyasu F. Estimation of characteristics of echo envelope using RF echo signal from the liver. Jpn J Appl Phys. 2001;40:3900–3904
  25. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: Diagnosis, grading and staging. Hepatology. 1994;19:1513–1520
  26. Masseroli M, Caballero T, O'Valle F, Del Moral RM, Pérez-Milena A, Del Moral RG. Automatic quantification of liver fibrosis: design and validation of a new image analysis method: comparison with semi-quantitative indexes of fibrosis. J Hepatol. 2000;32:453–464
  27. Wright M, Thursz M, Pullen R, Thomas H, Goldin R. Quantitative versus morphological assessment of liver fibrosis: semi-quantitative scores are more robust than digital image fibrosis area estimation. Liver Int. 2003;23:28–34
  28. Lin XZ, Horng MH, Sun YN, Shiesh SC, Chow NH, Guo XZ. Computer morphometry for quantitative measurement of liver fibrosis: Comparison with Knodell's score, colorimetry and conventional description reports. J Gastroenterol Hepatol. 1998;13:75–80
  29. Downey DB, Fenster A, Williams TC. Clinical utility of three-dimensional US. RadioGraphics. 2000;20:559–571
  30. Ziol M, Handra-Luca A, Kettaneh A, Chirstidis C, Mal F, Kazemi F, et al. Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C. Hepatology. 2005;41:48–54
  31. Castéra L, Vergnoil J, Foucher J, Le Bail B, Chanteloup E, Hasser M, et al. Prospective comparison of transient elastography, fibrotest, APRI, and liver biopsy for assessment of fibrosis in chronic hepatitis C. Gastroenterology. 2005;128:343–350

PII: S0168-8278(05)00569-6

doi: 10.1016/j.jhep.2005.08.009

Journal of Hepatology
Volume 44, Issue 1 , Pages 68-75 , January 2006