Journal of Hepatology
Volume 45, Issue 4 , Pages 600-606 , October 2006

Hepatic histology in obese patients undergoing bariatric surgery

  • Mariana Machado

      Affiliations

    • Departamento de Gastrenterologia, Instituto de Medicina Molecular (IMM), Faculdade de Medicina da Universidade de Lisboa, Portugal
    • ,
  • Pedro Marques-Vidal

      Affiliations

    • Departamento de Gastrenterologia, Instituto de Medicina Molecular (IMM), Faculdade de Medicina da Universidade de Lisboa, Portugal
    • ,
  • Helena Cortez-Pinto

      Affiliations

    • Departamento de Gastrenterologia, Instituto de Medicina Molecular (IMM), Faculdade de Medicina da Universidade de Lisboa, Portugal
    • Unidade de Nutrição e Metabolismo, Instituto de Medicina Molecular (IMM), Faculdade de Medicina da Universidade de Lisboa, Portugal
    • Corresponding Author InformationCorresponding author. Tel.: +351 21 7985187; fax: +351 21 7985142.

Received 15 May 2006 ,Revised 5 June 2006 ,Accepted 7 June 2006.

References 

  1. Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, Bellentani S. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology. 2005;42:44–52
  2. Wanless IR, Lentz JS. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology. 1990;12:1106–1110
  3. Neuschwander-Tetri BA, Roll FJ. Chemotatic activity for human PMN generated during ethanol metabolism by rat hepatocytes: role of glutathione and glutathione peroxidase. Biophys Res Commun. 1990;167:1170–1176
  4. Braillon A, Capron JP, Herve MA, Degott C, Quenum C. Liver in obesity. Gut. 1985;26:133–139
  5. Ratziu V, Giral P, Charlotte F. Liver fibrosis in overweight patients. Gastroenterology. 2000;118:1117–1123
  6. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 2001;50:1844–1850
  7. Chitturi S, Abeygunasekera S, Farrell GC, Holmes-Walker J, Hui JM, Fung C, et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology. 2002;35:373–379
  8. Pagano G, Pacini G, Musso G, Gambino R, Mecca F, Depetris N, et al. Nonalcoholic steatohepatitis, insulin resistence and metabolic syndrome: further evidence for an etiologic association. Hepatology. 2002;35:367–372
  9. Flegal KM. Trends in body weight and overweight in the U.S. population. Nutr Rev. 1996;54:S97–S100
  10. Luyckx FH, Desaive C, Thiry A, Dewe W, Scheen AJ, Gielen JE, et al. Liver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty. Int J Obes Relat Metab Disord. 1998;22:222–226
  11. Marceau P, Biron S, Hould FS, Marceau S, Simard S, Thung SN, et al. Liver pathology and the metabolic syndrome X in severe obesity. J Clin Endocrinol Metab. 1999;84:1513–1517
  12. Dixon JB, Bhathal PS, O’Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology. 2001;121:91–100
  13. Sepulveda-Flores RN, Vera-Cabrera L, Flores-Gutierrez JP, Maldonado-Garza H, Salinas-Garza R, Zorrilla-Blanco P, et al. Obesity-related non-alcoholic steatohepatitis and TGF-beta1 serum levels in relation to morbid obesity. Ann Hepatol. 2002;1:36–39
  14. Poniachik J, Mancilla C, Contreras J, Csendes A, Smok G, Cavada G, et al. [Obesity: risk factor for steatohepatitis and hepatic fibrosis]. Rev Med Chil. 2002;130:731–736
  15. Beymer C, Kowdley KV, Larson A, Edmonson P, Dellinger EP, Flum DR. Prevalence and predictors of asymptomatic liver disease in patients undergoing gastric bypass surgery. Arch Surg. 2003;138:1240–1244
  16. Spaulding L, Trainer T, Janiec D. Prevalence of non-alcoholic steatohepatitis in morbidly obese subjects undergoing gastric bypass. Obes Surg. 2003;13:347–349
  17. Frantzides CT, Carlson MA, Moore RE, Zografakis JG, Madan AK, Puumala S, et al. Effect of body mass index on nonalcoholic fatty liver disease in patients undergoing minimally invasive bariatric surgery. J Gastrointest Surg. 2004;8:849–855
  18. Abrams GA, Kunde SS, Lazenby AJ, Clements RH. Portal fibrosis and hepatic steatosis in morbidly obese subjects: a spectrum of nonalcoholic fatty liver disease. Hepatology. 2004;40:475–483
  19. Shalhub S, Parsee A, Gallagher SF, Haines KL, Willkomm C, Brantley SG, et al. The importance of routine liver biopsy in diagnosing nonalcoholic steatohepatitis in bariatric patients. Obes Surg. 2004;14:54–59
  20. Papadia FS, Marinari GM, Camerini G, Murelli F, Carlini F, Stabilini C, et al. Liver damage in severely obese patients: a clinical-biochemical-morphologic study on 1000 liver biopsies. Obes Surg. 2004;14:952–958
  21. Chavarria-Arciniega S, Lopez-Alvarenga JC, Uribe-Uribe NO, Herrera-Hernandez M, Gonzalez-Barranco J. [Relationship between morphological diagnosis of NASH (non-alcoholic steatohepatitis) and liver function test in a group of patients with morbid obesity. cases study]. Rev Invest Clin. 2005;57:505–512
  22. Ong JP, Elariny H, Collantes R, Younoszai A, Chandhoke V, Reines HD, et al. Predictors of nonalcoholic steatohepatitis and advanced fibrosis in morbidly obese patients. Obes Surg. 2005;15:310–315
  23. Boza C, Riquelme A, Ibanez L, Duarte I, Norero E, Viviani P, et al. Predictors of nonalcoholic steatohepatitis (NASH) in obese patients undergoing gastric bypass. Obes Surg. 2005;15:1148–1153
  24. Lima ML, Mourao SC, Diniz MT, Leite VH. Hepatic histopathology of patients with morbid obesity submitted to gastric bypass. Obes Surg. 2005;15:661–669
  25. Stratopoulos C, Papakonstantinou A, Terzis I, Spiliadi C, Dimitriades G, Komesidou V, et al. Changes in liver histology accompanying massive weight loss after gastroplasty for morbid obesity. Obes Surg. 2005;15:1154–1160
  26. Crespo J, Fernandez-Gil P, Hernandez-Guerra M, Cayon A, Mayorga M, Dominguez-Diez A, et al. Are there predictive factors of severe liver fibrosis in morbidly obese patients with non-alcoholic steatohepatitis?. Obes Surg. 2001;11:254–257
  27. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94:2467–2474
  28. Lee RG. Nonalcoholic steatohepatitis: tightening the morphological screws on a hepatic rambler. Hepatology. 1995;21:1742–1744
  29. Brunt EM. Pathology of nonalcoholic steatohepatitis. Hepatol Res. 2005;
  30. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–1321
  31. Ratziu V, Charlotte F, Heurtier A, Gombert S, Giral P, Bruckert E, et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology. 2005;128:1898–1906
  32. Sherlock S, Dooley JC. Nutritional and metabolic liver disease. 9th edition.  Sherlock S editors. Diseases of the liver and biliary system. 408. Oxford: Blackwell Scientific; 1993;
  33. Szczepaniak LS, Nurenberg P, Leonard D, Browning JD, Reingold JS, Grundy S, et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab. 2005;288:E462–E468
  34. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest. 2005;115:209–218
  35. Yokohama S, Yoneda M, Haneda M, Okamoto S, Okada M, Aso K, et al. Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. Hepatology. 2004;40:1222–1225
  36. Yokohama S, Tokusashi Y, Nakamura K, Tamaki Y, Okamoto S, Okada M, et al. Inhibitory effect of angiotensin II receptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis. World J Gastroenterol. 2006;12:322–326
  37. Mofrad P, Contos MJ, Haque M, Sargeant C, Fisher RA, Luketic VA, et al. Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology. 2003;37:1286–1292

PII: S0168-8278(06)00384-9

doi: 10.1016/j.jhep.2006.06.013

Journal of Hepatology
Volume 45, Issue 4 , Pages 600-606 , October 2006

Article Tools

* Image Usage & Resolution