Journal of Hepatology
Volume 47, Issue 2 , Pages 228-238 , August 2007

Kupffer cell activation in normal and fibrotic livers increases portal pressure via thromboxane A2

  • Christian J. Steib

      Affiliations

    • Department of Medicine II, Klinikum Großhadern, Ludwig-Maximilians University, Marchioninistraße 15, 81366 Munich, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 89 7095 3176; fax: +49 89 7095 2392.
    • ,
  • Alexander L. Gerbes

      Affiliations

    • Department of Medicine II, Klinikum Großhadern, Ludwig-Maximilians University, Marchioninistraße 15, 81366 Munich, Germany
    • ,
  • Markus Bystron

      Affiliations

    • Department of Medicine II, Klinikum Großhadern, Ludwig-Maximilians University, Marchioninistraße 15, 81366 Munich, Germany
    • ,
  • Mark op den Winkel

      Affiliations

    • Department of Medicine II, Klinikum Großhadern, Ludwig-Maximilians University, Marchioninistraße 15, 81366 Munich, Germany
    • ,
  • Josef Härtl

      Affiliations

    • Department of Medicine II, Klinikum Großhadern, Ludwig-Maximilians University, Marchioninistraße 15, 81366 Munich, Germany
    • ,
  • Frigga Roggel

      Affiliations

    • Institute of Pathology, University of Munich-Grosshadern, Munich, Germany
    • ,
  • Thomas Prüfer

      Affiliations

    • Department of Anesthesiology, University Hospital Tuebingen, Germany
    • ,
  • Burkhard Göke

      Affiliations

    • Department of Medicine II, Klinikum Großhadern, Ludwig-Maximilians University, Marchioninistraße 15, 81366 Munich, Germany
    • ,
  • Manfred Bilzer

      Affiliations

    • Department of Medicine II, Klinikum Großhadern, Ludwig-Maximilians University, Marchioninistraße 15, 81366 Munich, Germany

Received 3 August 2006 ,Revised 7 March 2007 ,Accepted 10 March 2007.

References 

  1. De Franchis R. Evolving consensus in portal hypertension. Report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2005;43:167–176
  2. Bosch J, Garcia-Pagan JC. Complications of cirrhosis. Portal hypertension. J Hepatol. 2000;32:141–156
  3. Rimola A, Bory F, Teres J, Perez-Ayuso RM, Arroyo V, Rodes J. Oral, nonabsorbable antibiotics prevent infection in cirrhotics with gastrointestinal hemorrhage. Hepatology. 1985;5:463–467
  4. Soriano G, Guarner C, Tomas A, Villanueva C, Torras X, Gonzales D, et al. Norfloxacin prevents bacterial infection in cirrhotics with gastrointestinal hemorrhage. Gastroenterology. 1992;103:1267–1272
  5. Bernard B, Cadranel JF, Valla D, Escolano S, Jarlier V, Opolon P. Prognostic significance of bacterial infection in bleeding cirrhotic patients: a prospective study. Gastroenterology. 1995;108:1828–1834
  6. Goulis J, Armonis A, Patch D, Sabin C, Greenslade L, Burroughs AK. Bacterial infection is independently associated with failure to control bleeding in cirrhotic patients with gastrointestinal hemorrhage. Hepatology. 1998;27:1207–1212
  7. Goulis J, Patch D, Burroughs AK. Bacterial infection in the pathogenesis of variceal bleeding. Lancet. 1999;353:139–142
  8. Klein A, Zhadkewich M, Margolick J, Winkelstein J, Bulkley G. Quantitative discrimination of hepatic reticuloendothelial clearance and phagocytic killing. J Leukoc Biol. 1994;55:248–252
  9. Fox ES, Thomas P, Broitman SA. Comparative studies of endotoxin uptake by isolated rat Kupffer and peritoneal cells. Infect Immunol. 1987;55:2962–2966
  10. Decker K. Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem. 1990;192:245–261
  11. Bilzer M, Gerbes AL. Kupffer cells. In:  Dufour JF,  Clavien PA editor. Signaling pathways in liver diseases. Vol. 5:Berlin, Heidelberg, New York: Springer-Verlag; 2005;p. 45–52
  12. Van de Casteele M, Hosli M, Sagesser H, Reichen J. Intraportal administration of glyceryl trinitrate or nitroprusside exerts more systemic than intrahepatic effects in anaesthetised cirrhotic rats. J Hepatol. 1999;31:300–305
  13. Sies H. The use of perfusion of liver and other organs for the study of microsomal electron-transport and cytochrome P-450 systems. Methods Enzymol. 1978;52:48–59
  14. Bilzer M, Baron A, Schauer R, Steib C, Ebensberger S, Gerbes AL. Glutathione treatment protects the rat liver against injury after warm ischemia and Kupffer cell activation. Digestion. 2002;66:49–57
  15. Bergemeyer HU. Methods of enzymatic analysis. New York: Academic Press; 1974;
  16. Kountouras J, Billing BH, Scheuer PJ. Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br J Exp Pathol. 1984;65:305–311
  17. Thornton BP, Vetvicka V, Pitman M, Goldman RC, Ross GD. Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18). J Immunol. 1996;156:1235–1246
  18. Schauer RJ, Bilzer M, Kalmuk S, Gerbes AL, Leiderer R, Schildberg FW, et al. Microcirculatory failure after rat liver transplantation is related to Kupffer cell-derived oxidant stress but not involved in early graft dysfunction. Transplantation. 2001;72:1692–1699
  19. Sato T, Yamamoto H, Sasaki C, Wake K. Maturation of rat dendritic cells during intrahepatic translocation evaluated using monoclonal antibodies and electron microscopy. Cell Tissue Res. 1998;294:503–514
  20. Dieter P, Altin JG, Decker K, Bygrave FL. Possible involvement of eicosanoids in the zymosan and arachidonic-acid-induced oxygen uptake, glycogenolysis and Ca2+ mobilization in the perfused rat liver. Eur J Biochem. 1987;165:455–460
  21. Damas J, Lagneaux D. Dissociation between the effects of zymosan on the systemic and pulmonary vessels of the rat. Br J Pharmacol. 1991;104:559–564
  22. Derbocio AM, Kelmer-Bracht AM, Bracht L, Bracht A, Ishii-Iwamoto EL. The hemodynamic effects of zymosan in the perfused rat liver. Vascul Pharmacol. 2005;43:75–85
  23. Keller SA, Paxian M, Ashburn JH, Clemens MG, Huynh T. Kupffer cell ablation improves hepatic microcirculation after trauma and sepsis. J Trauma. 2005;58:740–749discussion 749-51
  24. Crofford LJ. COX-1 and COX-2 tissue expression: implications and predictions. J Rheumatol. 1997;15–19
  25. Graupera M, Barcia-Pagan JC, Abraldes JG, Peralata C, Bragulat M, Corominola H, et al. Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers. Hepatology. 2003;37:172–181
  26. Ueno N, Murakami M, Tanioka T, Fujimori K, Tanabe T, Urade Y, et al. Coupling between cyclooxygenase, terminal prostanoid synthase, and phospholipase A2. J Biol Chem. 2001;276:34918–34927
  27. Häussinger D, Stehle T. Hepatocyte heterogeneity in response to icosanoids. Eur J Biochem. 1988;175:395–403
  28. Pestel S, Schlaf G, Gotze O, Jungermann K, Schieferdecker HL. Differences in the involvement of prostanoids from Kupffer cells in the mediation of anaphylatoxin C5a-, zymosan-, and lipopolysaccharide-dependent hepatic glucose output and flow reduction. Lab Invest. 2003;83:1733–1741
  29. Grinko I, Geerts A, Wisse E. Experimental biliary fibrosis correlates with increased numbers of fat-storing and Kupffer cells, and portal endotoxemia. J Hepatol. 1995;23:449–458
  30. Yokoyama Y, Xu H, Kresge N, Keller S, Sarmadi AH, Baveja R, et al. Role of thromboxane A2 in early BDL-induced portal hypertension. Am J Physiol Gastrointest Liver Physiol. 2003;284:G453–G460

☆ The authors who have taken part in this study declared that they do not have a relationship with the manufacturers of the drugs involved either in the past or present and did not receive funding from the manufacturers to carry out their research. They did not receive funding from any source to carry out this study.

PII: S0168-8278(07)00192-4

doi: 10.1016/j.jhep.2007.03.019

Journal of Hepatology
Volume 47, Issue 2 , Pages 228-238 , August 2007

Article Tools

* Image Usage & Resolution