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Journal of Hepatology
Volume 48, Issue 1
, Pages 51-60
, January 2008
Hepatitis C virus core protein impairs in vitro priming of specific T cell responses by dendritic cells and hepatocytes
References
- . Hepatitis C virus infection. N Engl J Med. 2001;345:41–52
- . T cell response in hepatitis C virus infection. J Clin Virol. 2005;32:75–85
- . Cellular immune responses against hepatitis C virus: the evidence base 2002. Clin Exp Immunol. 2002;128:195–203
- High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology. 2004;127:924–936
- Analysis of a successful immune response against hepatitis C virus. Immunity. 1999;10:439–449
- Differential CD4(+) and CD8(+) T-cell responsiveness in hepatitis C virus infection. Hepatology. 2001;33:267–276
- . Dendritic cells and immune regulation in the liver. Gut. 2003;52:307–314
- Abnormal priming of CD4(+) T cells by dendritic cells expressing hepatitis C virus core and E1 proteins. J Virol. 2002;76:5062–5070
- Hepatitis C virus structural proteins impair dendritic cell maturation and inhibit in vivo induction of cellular immune responses. J Virol. 2003;77:10862–10871
- . Antigen-presentation by liver cells controls intrahepatic T cell trapping, whereas bone marrow-derived cells preferentially promote intrahepatic T cell apoptosis. J Immunol. 2001;167:667–673
- . Antigen-specific primary activation of CD8+ T cells within the liver. J Immunol. 2001;166:5430–5438
- Early intrahepatic antigen-specific retention of naive CD8+ T cells is predominantly ICAM-1/LFA-1 dependent in mice. Hepatology. 2005;42:1063–1071
- . Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature. 2005;436:946–952
- Steatosis and intrahepatic lymphocyte recruitment in hepatitis C virus transgenic mice. J Gen Virol. 2004;85:1509–1520
- . Dendritic cells pulsed with exogenous hepatitis B surface antigen particles efficiently present epitopes to MHC class I-restricted cytotoxic T cells. Eur J Immunol. 2002;32:1099–1108
- . Activating immunity in the liver. I. Liver dendritic cells (but not hepatocytes) are potent activators of IFN-gamma release by liver NKT cells. J Immunol. 2001;167:1413–1422
- . Specific, functional effector/memory CD8+ T cells are found in the liver post-vaccination. J Hepatol. 2003;39:910–917
- Hepatic dendritic cell subsets in the mouse. Eur J Immunol. 2004;34:355–365
- . Recently primed CD8+ T cells entering the liver induce hepatocytes to interact with naive CD8+ T cells in the mouse. Hepatology. 2004;39:1256–1266
- Subversion of effector CD8+ T cell differentiation in acute hepatitis C virus infection: the role of the virus. Eur J Immunol. 2004;34:438–446
- Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy. J Virol. 2005;79:12979–12988
- . Evasion of intracellular host defence by hepatitis C virus. Nature. 2005;436:939–945
- . Hepatitis C virus infection How does the host respond?. Minerva Gastroenterol Dietol. 2004;50:21–28
- . Mechanisms inducing or controlling CD8+ T cell responses against self- or non-self-antigens. Ann NY Acad Sci. 2003;987:99–106
- . Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 induction. Alcohol Clin Exp Res. 2003;27:1023–1031
- Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation. J Immunol. 2003;170:5615–5624
- Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice. Gastroenterology. 2003;124:1465–1475
- T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol. 2005;79:7860–7867
- Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection. J Virol. 2005;79:7852–7859
- Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection. J Clin Invest. 2004;113:963–972
- . Hepatitis C virus core protein inhibits human T lymphocyte responses by a complement-dependent regulatory pathway. J Immunol. 2001;167:5264–5272
- . Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt. J Virol. 2004;78:6409–6419
☆ The authors declare that they do not have anything to disclose regarding conflict of interest with respect to this manuscript.
PII: S0168-8278(07)00530-2
doi: 10.1016/j.jhep.2007.08.008
© 2007 European Association for the Study of the Liver. Published by Elsevier Inc. All rights reserved.
« Previous
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Journal of Hepatology
Volume 48, Issue 1
, Pages 51-60
, January 2008
