« Previous
Next »
Journal of Hepatology
Volume 48
, Pages S104-S112
, 2008
Non-alcoholic fatty liver disease: The mist gradually clears
References
- . Prevalence and risk factors for non-alcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology. 2005;42:44–52
- Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004;40:1387–1395
- . Prevalence of fatty liver in a general population of Okinawa Japan. Jpn J Med. 1988;27:142–149
- Incidence and natural course of fatty liver in the general population: The Dionysos Study. Hepatology. 2007;46:1387–1391
- . Non alcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology. 2003;37:1202–1219
- . Hepatic histology in patients undergoing bariatric surgery. J Hepatol. 2006;45:600–606
- . Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology. 1990;12:1106–1110
- The impact of fat distribution on the severity of non-alcoholic fatty liver disease and the metabolic syndrome. Hepatology. 2007;46:1091–1100
- Relation between carotid artery wall thickness and liver histology in subjects with non-alcoholic fatty liver disease. Diabetes Care. 2006;29:1325–1330
- Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease among Type 2 diabetic patients. Diabetes Care. 2007;30:1212–1218
- Non-alcoholic fatty liver, steatohepatitis and the metabolic syndrome. Hepatology. 2003;37:917–923
- Liver involvement in obese children. Ultrasonography and liver enzyme levels at diagnosis and during follow up in an Italian population. Dig Dis Sci. 1997;42:1428–1432
- Prevalence of fatty liver in Japanese children and relationship to obesity. An epidemiological ultrasonographic survey. Dig Dis Sci. 1995;40:2002–2009
- . Obese children with steatohepatitis can develop cirrhosis in childhood. Am J Gastroenterol. 2002;97:2460–2462
- Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology. 2006;44:865–873
- . Natural history of NAFLD: remarkably benign in the absence of cirrhosis. Gastroenterology. 2005;129:375–378
- Similarities and differences in outcomes of cirrhosis due to non-alcoholic steatohepatitis and hepatitis C. Hepatology. 2006;43:682–689
- . Is obesity an independent risk factor for hepatocellular carcinoma in cirrhosis?. Hepatology. 2002;36:150–155
- . Overweight, obesity and mortality from cancer in a prospectively studied cohort of US adults. N Engl J Med. 2003;348:1625–1638
- . The clinical features, diagnosis and natural history of non-alcoholic fatty liver disease. Clin Liver Dis. 2004;8:521–533
- The natural history of non-alcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005;129:113–121
- . Genetics of alcoholic liver disease and non-alcoholic fatty liver disease. Semin Liver Dis. 2007;27:44–54
- Dietary habits and their relations to insulin resistance and postprandial lipemia in non-alcoholic steatohepatitis. Hepatology. 2003;37:909–916
- Long term nutritional intake and the risk of non-alcoholic fatty liver disease (NAFLD): a population based study. J Hepatol. 2007;47:711–717
- . Excess weight risk factor for alcoholic liver disease. Hepatology. 1997;25:108–111
- . Non-alcoholic fatty liver disease: predictors of non-alcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology. 2001;121:91–100
- . Light to moderate alcohol consumption is associated with lower frequency of hypertransaminasemia. Am J Gastroenterol. 2007;102:1912–1919
- De Alwis N, Day CP. Genes and non-alcoholic fatty liver disease. Curr Diab Rep, in press.
- . Non alcoholic hepatic steatosis and its relation to increased plasma biomarkers of inflammation and endothelial dysfunction in nondiabetic men. Role of visceral adipose tissue. Diabet Med. 2005;22:1354–1358
- Carotid artery intima-media thickness in non-alcoholic fatty liver disease. Am J Med. 2008;121:72–78
- . Fatty liver as a determinant of atherosclerosis. Hepatology. 2005;42:610A
- Targher G, Bertolini L, Rodella S, Zoppini G, Lippi G, Day CP. Non-alcoholic fatty liver disease is independantly associated with an increased prevalence of Chronic kidney disease and proliferative/laser treated retinopathy in type 2 diabetic patients. Diabetologia, Epub ahead of print, doi:10.1007/s00125-007-0897-4.
- . Non-alcoholic fatty liver disease and increased risk of cardiovascular disease. Atherosclerosis. 2007;191:235–240
- . Abnormal aminotransferase activity in women with polycystic ovary syndrome. Fertil Steril. 2005;83:494–497
- Non-alcoholic fatty Liver disease in women with polycystic ovary syndrome. J Hepatol. 2007;47:412–417
- . Non-alcoholic steatohepatitis and non-alcoholic fatty liver disease in young women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006;91:1741–1747
- . Obesity related cardiovascular disease: implications of obstructive sleep apnea. Diabet Obes Met. 2005;8:250–260
- Chronic liver injury during obstructive sleep apnea. Hepatology. 2005;41:1290–1296
- . Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology. J Hepatol. 2001;35:195–199
- Prevalence and etiology of altered liver tests: a population based survey in a Mediterranean town. Hepatology. 2005;41:1151–1159
- Clinical and histologic spectrum of non-alcoholic fatty liver disease associated with normal ALT values. Hepatology. 2003;37:1286–1292
- Leptin reverses non-alcoholic steatohepatitis in patients with severe lipodystrophy. Hepatology. 2005;41:753–760
- . Fatty Liver in familial hypobetalipoproeteinaemia: roles of the APOB defects, intra-abdominal adipose tissue, and insulin sensitivity. J Lipid Res. 2004;45:941–947
- . Ferritin, metabolic syndrome and NAFLD: Elective attractions and dangerous liaisons. J Hepatol. 2007;46:549–552
- Relative contribution of iron burden, HFE mutations and insulin resistance to fibrosis in non-alcoholic fatty liver. Hepatology. 2004;39:179–187
- . The prevalence of autoantibodies and autoimmune hepatitis in patients with non-alcoholic fatty liver disease. Am J Gastroenterol. 2004;90:1316–1320
- . The prevalence of autoantibodies and autoimmune hepatitis in patients with non-alcoholic fatty liver disease. Am J Gastroenterol. 2005;100:1200–1201
- The utility of radiological imaging in non-alcoholic fatty liver disease. Gastroenterology. 2002;123:745–750
- . Current and Future applications of in vitro magnetic resonance spectroscopy in hepatobiliary disease. World J Gastroenterol. 2006;12:4773–4783
- . Transient elastography in patients with non-alcoholic fatty liver disease (NAFLD). Gut. 2007;56:1330–1331
- . Non-invasive markers associated with liver fibrosis in non-alcoholic fatty liver disease. Gut. 2006;55:1650–1660
- The NAFLD fibrosis score: a non-invasive system that accurately identifies liver fibrosis in patients with NAFLD. Hepatology. 2007;45:846–854
- Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology. 2004;127:1704–1713
- Non-invasive markers of fibrosis in non-alcoholic fatty liver disease: validating the European Liver Fibrosis panel and exploring simple markers. Hepatology. 2007;47:455–460
- . In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in non-alcoholic fatty liver disease. Hepatology. 2006;44:27–33
- . From fat to inflammation. Gastroenterology. 2006;130:207–210
- . Benefits of lifestyle modification in NAFLD. Gut. 2007;56:1760–1769
- . Dietary fat content modifies liver fat in overweight nondiabetic subjects. J Clin Endocrinol Metab. 2005;90:2804–2809
- Therapeutic effects of diet and exercise in obese patients with fatty liver. J Hepatol. 1997;27:103–110
- . A pilot study of orlistat treatment in obese, non-alcoholic steatohepatitis patients. Aliment Pharm Ther. 2004;20:623–628
- . Orlistat reverses fatty infiltration and improves hepatic fibrosis in obese patients with non-alcoholic steatohepatitis (NASH). Dig Dis Sci. 2007;52:2512–2519
- . RIO-Europe Study Group. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet. 2005;365:1389–1397
- Rimonabant reduces obesity associated hepatic steatosis and features of the metabolic syndrome in obese Zucker fa/fa Rats. Hepatology. 2007;46:122–129
- CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat Med. 2006;12:671–676
- . Improvement in liver histological analysis with weight loss. Hepatology. 2004;39:1647–1654
- Gastric bypass surgery improves metabolic and hepatic abnormalities associated with non-alcoholic fatty liver disease. Gastroenterology. 2006;130:1564–1572
- . The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology. 2007;132:1434–1446
- . Effects of insulin therapy on liver fat content and hepatic insulin sensitivity in patients with type 2 diabetes. Am J Physiol Endocrinol Metab. 2006;292:E829–E835
- A randomized controlled trial of metformin versus vitamin E or prescriptive diet in non-alcoholic fatty liver disease. Am J Gastroenterol. 2005;100:1082–1090
- Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology. 2002;122:1924–1940
- A placebo controlled trial of pioglitazone in subjects with non-alcoholic steatohepatitis. N Engl J Med. 2006;355:2297–2307
- . Long-term risk of cardiovascular events with rosiglitazone. A meta-analysis. J Am Med Ass. 2007;298:1189–1195
- . Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus. J Am Med Ass. 2007;298:1180–1188
- The effects of discontinuing pioglitazone in patients with non-alcoholic steatohepatitis. Hepatology. 2007;46:424–429
- . Administration of the potent PPAR alpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology. 2004;39:1286–1296
- Ursodeoxycholic acid or clofibrate in the treatment of non-alcoholic induced steatohepatitis: a pilot study. Hepatology. 1996;23:1464–1467
- . Statins and hepatic steatosis: perspectives from the Dallas Heart Study. Hepatology. 2006;44:466–471
- Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis. Hepatology. 2007;45:1375–1381
- Therapeutic efficacy of an angiotensinogen II receptor antagonist in patients with nonalcoholic steatohepatitis. Hepatology. 2004;40:1222–1225
- Norepinephrine induces hepatic fibrosis in leptin deficient ob/ob mice. Biochem Biophys Res Commun. 2003;308:284–292
- . Comparative effects of Telmisartan and valsartan on insulin resistance in hypertensive patients with metabolic syndrome. Intern Med. 2007;46:1331–1336
- Probucol in the treatment of non-alcoholic steatohepatitis: a double blind randomized controlled study. J Hepatol. 2003;38:414–418
- . Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol. 2001;96:2711–2717
- . Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease. Gastroenterology. 2002;122:931–939
- . Vitamin E treatment of non-alcoholic steatohepatitis in children: a pilot study. J Pediatr. 2000;136:734–738
- . Vitamin E and Vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol. 2003;98:2485–2490
- . A pilot trial of pentoxyfylline in nonalcoholic steatohepatitis. Am J Gastroenterol. 2004;99:2365–2368
- . Beneficial effects of pentoxifylline on hepatic steatosis, fibrosis and necroinflammation in patients with non alcoholic steatohepatitis. J Gastroenterol Hepatol. 2007;22:634–638
- Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. 2006;313:1137–1140
- Ursodeoxycholic acid for treatment of non alcoholic steatohepatitis: results of a randomized trial. Hepatology. 2004;39:770–778
- Swiss Association for the Study of the Liver: randomized placebo controlled trial of ursodeoxycholic acid with Vitamin E in non-alcoholic steatohepatitis. Clin Gastroentrol Hepatol. 2006;4:1537–1543
- Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis. Liver Transpl. 2001;7:363–373
- Cryptogenic cirrhosis and post-transplantation nonalcoholic fatty liver disease. Liver Transpl. 2001;7:797–801
☆ C.P. Day is currently Chief investigator on a Sanofi-Aventis sponsored trial of rimonabant in non-alcoholic fatty liver disease. He has consultancies with Pfizer, UK Ltd., GlaxoSmithKline and Astellas with respect to developing therapies for NAFLD. He has received funding from ROCHE products UK to perform a study of orlistat in non-alcoholic fatty liver disease. He declares that he received funding from the Medical Research Council, UK, The Wellcome Trust, The Department of Health, UK and the Commonwealth Scholarship Commission.
PII: S0168-8278(08)00055-X
doi: 10.1016/j.jhep.2008.01.009
© 2008 European Association for the Study of the Liver. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of Hepatology
Volume 48
, Pages S104-S112
, 2008
