Journal of Hepatology
Volume 48, Issue 6 , Pages 952-961 , June 2008

Critical role of CD44 in hepatotoxin-mediated liver injury

  • Kiminori Kimura

      Affiliations

    • Department of Immunotherapeutics (Medinet), Graduate School of Medicine, The University of Tokyo, 1-3-7 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • Center for Emerging Infectious Diseases, Gifu University, Gifu-shi, Gifu 501-1194, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 3 5805 3161; fax: +81 3 5805 3164.
  • ,
  • Masahito Nagaki

      Affiliations

    • First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, Gifu 501-1194, Japan
  • ,
  • Kazuhiro Kakimi

      Affiliations

    • Department of Immunotherapeutics (Medinet), Graduate School of Medicine, The University of Tokyo, 1-3-7 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
  • ,
  • Masanao Saio

      Affiliations

    • Department of Immunopathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, Gifu 501-1194, Japan
  • ,
  • Tomomi Saeki

      Affiliations

    • Center for Emerging Infectious Diseases, Gifu University, Gifu-shi, Gifu 501-1194, Japan
  • ,
  • Yumiko Okuda

      Affiliations

    • Center for Emerging Infectious Diseases, Gifu University, Gifu-shi, Gifu 501-1194, Japan
  • ,
  • Kazuo Kuwata

      Affiliations

    • Center for Emerging Infectious Diseases, Gifu University, Gifu-shi, Gifu 501-1194, Japan
  • ,
  • Hisataka Moriwaki

      Affiliations

    • First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, Gifu 501-1194, Japan

Received 16 August 2007 ,Revised 5 December 2007 ,Accepted 3 January 2008.

References 

  1. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301–314
  2. Springer TA. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol. 1995;57:827–872
  3. John AE, Lukacs NW, Berlin AA, Palecanda A, Bargatze RF, Stoolman LM, et al. Discovery of a potent nanoparticle P-selectin antagonist with anti-inflammatory effects in allergic airway disease. FASEB J. 2003;17:2296–2298
  4. Abdelbaqi M, Chidlow JH, Matthews KM, Pavlick KP, Barlow SC, Linscott AJ, et al. Regulation of dextran sodium sulfate induced colitis by leukocyte beta 2 integrins. Lab Invest. 2006;86:380–390
  5. Brocke S, Piercy C, Steinman L, Weissman IL, Veromaa T. Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. Proc Natl Acad Sci USA. 1999;96:6896–6901
  6. Egerer K, Hertzer J, Feist E, Albrecht A, Rudolph PE, Dorner T, et al. sE-selectin for stratifying outcome in rheumatoid arthritis. Arthritis Rheum. 2003;49:546–548
  7. Ponta H, Sherman L, Herrlich PA. CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol. 2003;4:33–45
  8. Schmits R, Filmus J, Gerwin N, Senaldi G, Kiefer F, Kundig T, et al. CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood. 1997;90:2217–2233
  9. Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Pure E, et al. Resolution of lung inflammation by CD44. Science. 2002;296:155–158
  10. Laskin DL, Pendino KJ. Macrophages and inflammatory mediators in tissue injury. Annu Rev Pharmacol Toxicol. 1995;35:655–677
  11. Jungermann K, Katz N. Functional specialization of different hepatocyte populations. Physiol Rev. 1989;69:708–764
  12. Luster MI, Simeonova PP, Gallucci RM, Bruccoleri A, Blazka ME, Yucesoy B. Role of inflammation in chemical-induced hepatotoxicity. Toxicol Lett. 2001;120:317–321
  13. Chen D, McKallip RJ, Zeytun A, Do Y, Lombard C, Robertson JL, et al. CD44-deficient mice exhibit enhanced hepatitis after concanavalin A injection: evidence for involvement of CD44 in activation-induced cell death. J Immunol. 2001;166:5889–5897
  14. Kimura K, Moriwaki H, Nagaki M, Saio M, Nakamoto Y, Naito M, et al. Pathogenic role of B cells in anti-CD40-induced necroinflammatory liver disease. Am J Pathol. 2006;168:786–795
  15. Kimura K, Nagaki M, Takai S, Satake S, Moriwaki H. Pivotal role of nuclear factor kappaB signaling in anti-CD40-induced liver injury in mice. Hepatology. 2004;40:1180–1189
  16. Nagaki M, Naiki T, Brenner DA, Osawa Y, Imose M, Hayashi H, et al. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fasmediated apoptosis: role of nuclear factor-kappaB. Hepatology. 2000;32:1272–1279
  17. Duffield JS, Forbes SJ, Constandinou CM, Clay S, Partolina M, Vuthoori S, et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest. 2005;115:56–65
  18. Mikecz K, Brennan FR, Kim JH, Glant TT. Anti-CD44 treatment abrogates tissue edema and leukocyte infiltration in murine arthritis. Nat Med. 1995;1:558–563
  19. McKallip RJ, Fisher M, Gunthert U, Szakal AK, Nagarkatti PS, Nagarkatti M. Role of CD44 and its v7 isoform in staphylococcal enterotoxin B-induced toxic shock: CD44 deficiency on hepatic mononuclear cells leads to reduced activation-induced apoptosis that results in increased liver damage. Infect Immun. 2005;73:50–61
  20. Katoh S, Matsumoto N, Kawakita K, Tominaga A, Kincade PW, Matsukura S. A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia. J Clin Invest. 2003;111:1563–1570
  21. Siegelman MH, Stanescu D, Estess P. The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm adhesion. J Clin Invest. 2000;105:683–691
  22. Khan AI, Kerfoot SM, Heit B, Liu L, Andonegui G, Ruffell B, et al. Role of CD44 and hyaluronan in neutrophil recruitment. J Immunol. 2004;173:7594–7601
  23. Wang Q, Teder P, Judd NP, Noble PW, Doerschuk CM. CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in mice. Am J Pathol. 2002;161:2219–2228
  24. Nakamura K, Okada M, Yoneda M, Takamoto S, Nakade Y, Tamori K, et al. Macrophage inflammatory protein-2 induced by TNFalpha plays a pivotal role in concanavalin A-induced liver injury in mice. J Hepatol. 2001;35:217–224
  25. Takai S, Kimura K, Nagaki M, Satake S, Kakimi K, Moriwaki H. Blockade of neutrophil elastase attenuates severe liver injury in hepatitis B transgenic mice. J Virol. 2005;79:15142–15150
  26. Jaeschke H, Smith CW. Cell adhesion and migration. III. Leukocyte adhesion and transmigration in the liver vasculature. Am J Physiol. 1997;273:G1169–G1173
  27. Bonder CS, Ajuebor MN, Zbytnuik LD, Kubes P, Swain MG. Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis. J Immunol. 2004;172:45–53
  28. Liang J, Jiang D, Griffith J, Yu S, Fan J, Zhao X, et al. CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages. J Immunol. 2007;178:2469–2475
  29. Wittig BM, Johansson B, Zoller M, Schwarzler C, Gunthert U. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7). J Exp Med. 2000;191:2053–2064
  30. Vachon E, Martin R, Plumb J, Kwok V, Vandivier RW, Glogauer M, et al. CD44 is a phagocytic receptor. Blood. 2006;107:4149–4158
  31. Karin M Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol. 2002;3:221–227

 The authors who have taken part in the research of this paper declared that they have a relationship with the manufacturers of the materials involved either in the past or present but they did not receive funding from the manufacturers to carry out their research.

PII: S0168-8278(08)00135-9

doi: 10.1016/j.jhep.2008.01.033

Journal of Hepatology
Volume 48, Issue 6 , Pages 952-961 , June 2008