Journal of Hepatology
Volume 48, Issue 6 , Pages 939-944 , June 2008

Incidence and mortality of primary sclerosing cholangitis in the UK: A population-based cohort study

  • Tim R. Card

      Affiliations

    • University of Nottingham Medical School, Division of Epidemiology and Public Health, Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, UK
    • Department of Gastroenterology, Kings Mill Hospital, Mansfield Road, Sutton, Ashfield NG17 4JT, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 (0) 115 8230441; fax: +44 (0) 115 8230464.
  • ,
  • Masoud Solaymani-Dodaran

      Affiliations

    • University of Nottingham Medical School, Division of Epidemiology and Public Health, Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, UK
  • ,
  • Joe West

      Affiliations

    • University of Nottingham Medical School, Division of Epidemiology and Public Health, Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, UK

Received 26 October 2007 ,Revised 25 January 2008 ,Accepted 19 February 2008.

References 

  1. LaRusso NF, Shneider BL, Black D, Gores GJ, James SP, Doo E, et al. Primary sclerosing cholangitis: summary of a workshop. Hepatology. 2006;44:746–764
  2. Angulo P, Lindor KD. Primary sclerosing cholangitis. Hepatology. 1999;30:325–332
  3. Kingham JG, Kochar N, Gravenor MB. Incidence, clinical patterns, and outcomes of primary sclerosing cholangitis in South Wales, United Kingdom. Gastroenterology. 2004;126:1929–1930
  4. Boberg KM, Aadland E, Jahnsen J, Raknerud N, Stiris M, Bell H. Incidence and prevalence of primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis in a Norwegian population. Scand J Gastroenterol. 1998;33:99–103
  5. Bambha K, Kim WR, Talwalkar J, Torgerson H, Benson JT, Therneau TM, et al. Incidence, clinical spectrum, and outcomes of primary sclerosing cholangitis in a United States community. Gastroenterology. 2003;125:1364–1369
  6. Jick H, Jick SS, Derby LE. Validation of information recorded on general practitioner based computerised data resource in the United Kingdom. BMJ. 1991;302:766–768
  7. Jick H, Terris BZ, Derby LE, Jick S. Further validation of information recorded on a general practitioner based computerized data resource in the United Kingdom. Pharmacoepidemiol Drug Saf. 1992;1:347–349
  8. Lewis JD, Brensinger C, Bilker WB, Strom BL. Validity and completeness of the General Practice Research Database for studies of inflammatory bowel disease. Pharmacoepidemiol Drug Saf. 2002;11:211–218
  9. Hubbard R, Venn A, Lewis S, Britton J. Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study. Am J Respir Crit Care Med. 2000;161:5–8
  10. Card T, Hubbard R, Logan RF. Mortality in inflammatory bowel disease: a population-based cohort study. Gastroenterology. 2003;125:1583–1590
  11. Lewis JD, Bilker WB, Weinstein RB, Strom BL. The relationship between time since registration and measured incidence rates in the General Practice Research Database. Pharmacoepidemiol Drug Saf. 2005;14:443–451
  12. West J, Logan RF, Smith CJ, Hubbard RB, Card TR. Malignancy and mortality in people with coeliac disease: population based cohort study. BMJ. 2004;329:716–719
  13. Solaymani-Dodaran M, Logan RF, West J, Card T. Mortality associated with Barrett’s esophagus and gastroesophageal reflux disease diagnoses–a population-based cohort study. Am J Gastroenterol. 2005;100:2616–2621
  14. Beuers U. Hepatic overlap syndromes. J Hepatol. 2005;42:S93–S99
  15. Kingham JG, Abbasi A. Co-existence of primary biliary cirrhosis and primary sclerosing cholangitis: a rare overlap syndrome put in perspective. Eur J Gastroenterol Hepatol. 2005;17:1077–1080
  16. Escorsell A, Pares A, Rodes J, Solis-Herruzo JA, Miras M, de la Morena E. Epidemiology of primary sclerosing cholangitis in Spain. Spanish Association for the study of the liver. J Hepatol. 1994;21:787–791
  17. Barrison IG, Bramble MG, Wilkinson M, Hodson R, Fairclough PD, Willoughby CP, et al. Provision of endoscopy related services in district general hospitals: BSG Working Party Report 2001; 2001.
  18. Hollowell J. The General Practice Research Database: quality of morbidity data. Popul Trends. 1997;87:36–40
  19. Chapman RW, Arborgh BA, Rhodes JM, Summerfield JA, Dick R, Scheuer PJ, et al. Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology. Gut. 1980;21:870–877
  20. Okolicsanyi L, Fabris L, Viaggi S, Carulli N, Podda M, Ricci G. Primary sclerosing cholangitis: clinical presentation, natural history and prognostic variables: an Italian multicentre study. The Italian PSC study group. Eur J Gastroenterol Hepatol. 1996;8:685–691
  21. Aadland E, Schrumpf E, Fausa O, Elgjo K, Heilo A, Aakhus T, et al. Primary sclerosing cholangitis: a long-term follow-up study. Scand J Gastroenterol. 1987;22:655–664
  22. Farrant JM, Hayllar KM, Wilkinson ML, Karani J, Portmann BC, Westaby D, et al. Natural history and prognostic variables in primary sclerosing cholangitis. Gastroenterology. 1991;100:1710–1717

 The authors declare that they do not have anything to disclose regarding funding from industries or conflict of interest with respect to this manuscript. J.W. is funded by a Department of Health Clinician Scientist Fellowship.

PII: S0168-8278(08)00206-7

doi: 10.1016/j.jhep.2008.02.017

Journal of Hepatology
Volume 48, Issue 6 , Pages 939-944 , June 2008