Journal of Hepatology
Volume 49, Issue 2 , Pages 170-174 , August 2008

Association of t(14;18) translocation with HCV infection in gastrointestinal MALT lymphomas

  • Massimo Libra

      Affiliations

    • Department of Biomedical Sciences, University of Catania, Via Androne, 83-95124 Catania, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 095 313429; fax: +39 095 315257.
    • ,
  • Annunziata Gloghini

      Affiliations

    • Department of Pathology, National Cancer Institute, Fondazione IRCCS Milano, Italy
    • ,
  • Grazia Malaponte

      Affiliations

    • Department of Biomedical Sciences, University of Catania, Via Androne, 83-95124 Catania, Italy
    • ,
  • Pietro Gangemi

      Affiliations

    • Division of Pathology, Vittorio Emanuele II Hospital, Catania, Italy
    • ,
  • Valli De Re

      Affiliations

    • Division of Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy
    • ,
  • Bruno Cacopardo

      Affiliations

    • Department of Internal Medicine and Medical Specialties, Section of Infectious Diseases, University of Catania, Italy
    • ,
  • Demetrios A. Spandidos

      Affiliations

    • Department of Virology, Medical School, University of Crete, Heraklion, Greece
    • ,
  • Ferdinando Nicoletti

      Affiliations

    • Department of Biomedical Sciences, University of Catania, Via Androne, 83-95124 Catania, Italy
    • ,
  • Franca Stivala

      Affiliations

    • Department of Biomedical Sciences, University of Catania, Via Androne, 83-95124 Catania, Italy
    • ,
  • Anna Linda Zignego

      Affiliations

    • Department of Internal Medicine, University of Florence, Italy
    • ,
  • Antonino Carbone

      Affiliations

    • Department of Pathology, National Cancer Institute, Fondazione IRCCS Milano, Italy

Received 28 February 2008 ,Revised 26 March 2008 ,Accepted 26 March 2008.

References 

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  2. Sagaert X, De Wolf-Peeters C, Noels H, Baens M. The pathogenesis of MALT lymphomas: where do we stand?. Leukemia. 2007;21:389–396
  3. Palmedo G, Hantschke M, Rütten A, Mentzel T, Kempf W, Tomasini D, et al. Primary cutaneous marginal zone B-cell lymphoma may exhibit both the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18) (q32;q21) IGH/MALT1 translocation: an indicator for clonal transformation towards higher-grade B-cell lymphoma?. Am J Dermatopath. 2007;29:231–236
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  5. Libra M, De Re V, De Vita S, Gasparotto D, Gloghini A, Rupolo M, et al. Low frequency of bcl-2 rearrangement in HCV-associated non-Hodgkin’s lymphoma tissue. Leukemia. 2003;17:1433–1436
  6. Streubel B, Simonitsch-Klupp I, Müllauer L, Lamprecht A, Huber D, Siebert R, et al. Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites. Leukemia. 2004;18:1722–1726
  7. Jaffe ES, Harris NL, Stein H, Vardiman JW. World Health Organization Classification of Tumours. Pathology and Genetics: Tumours of Haemopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001;
  8. Libra M, Gloghini A, De Re V, Rupolo M, Navolanic PM, Gasparotto D, et al. Aggressive forms of non-Hodgkin’s lymphoma in two patients bearing coinfection of Epstein-Barr and hepatitis C viruses. Int J Oncol. 2005;26:945–950
  9. Libra M, Capello D, Gloghini A, Laura P, Berra E, Cerri M, et al. Analysis of aberrant somatic hypermutation (SHM) in non-Hodgkin’s lymphomas of patients with chronic HCV infection. J Pathol. 2005;206:87–91
  10. Carbone A, Cilia AM, Gloghini A, Canzonieri V, Pastore C, Todesco M, et al. Establishment of HHV-8-positive and HHV-8-negative lymphoma cell lines from primary lymphomatous effusions. Int J Cancer. 1997;73:562–569
  11. Libra M, Gloghini A, Navolanic PM, Zignego AL, De Re V, Carbone A. JH6 gene usage among HCV-associated MALT lymphomas harboring t(14;18) translocation. J Immunol. 2005;174:3839
  12. De Re V, De Vita S, Marzotto A, Rupolo M, Gloghini A, Pivetta B, et al. Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus-associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor-producing cells that occur mainly in type II cryoglobulinemia. Blood. 2000;96:3578–3584
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  15. Zuckerman E, Zuckerman T, Sahar D, Streichman S, Attias D, Sabo E, et al. bcl-2 and immunoglobulin gene rearrangement in patients with hepatitis C virus infection. Br J Haematol. 2001;112:364–369
  16. Zignego AL, Ferri C, Giannelli F, Giannini C, Caini P, Monti M, et al. Prevalence of bcl-2 rearrangement in patients with hepatitis C virus-related mixed cryoglobulinemia with or without B-cell lymphomas. Ann Int Med. 2002;137:571–580
  17. Casato M, Mecucci C, Agnello V, Fiorilli M, Knight GB, Matteucci C, et al. Regression of lymphoproliferative disorder after treatment for hepatitis C virus infection in a patient with partial trisomy 3, Bcl-2 overexpression, and type II cryoglobulinemia. Blood. 2002;99:2259–2261
  18. Pan L, Diss TC, Cunningham D, Isaacson PG. The bcl-2 gene in primary B cell lymphoma of mucosa-associated lymphoid tissue (MALT). Am J Pathol. 1989;135:7–11
  19. Capello D, Vitolo U, Pasqualucci L, Quattrone S, Migliaretti G, Fassone L, et al. Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia. Blood. 2000;95:651–659

☆ The authors declare that they do not have anything to disclose regarding funding from industries or conflict of interest with respect to this manuscript.

PII: S0168-8278(08)00232-8

doi: 10.1016/j.jhep.2008.03.031

Journal of Hepatology
Volume 49, Issue 2 , Pages 170-174 , August 2008

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