Journal of Hepatology
Volume 49, Issue 2 , Pages 217-222 , August 2008

Doxorubicin-eluting bead-enhanced radiofrequency ablation of hepatocellular carcinoma: A pilot clinical study

  • Riccardo Lencioni

      Affiliations

    • Division of Diagnostic and Interventional Radiology, Department of Oncology and Radiology, Cisanello University Hospital – Building No. 9, Via Paradisa 2, IT-56124 Pisa, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 050 992 509; fax: +39 050 551 461.
  • ,
  • Laura Crocetti

      Affiliations

    • Division of Diagnostic and Interventional Radiology, Department of Oncology and Radiology, Cisanello University Hospital – Building No. 9, Via Paradisa 2, IT-56124 Pisa, Italy
  • ,
  • Pasquale Petruzzi

      Affiliations

    • Division of Diagnostic and Interventional Radiology, Department of Oncology and Radiology, Cisanello University Hospital – Building No. 9, Via Paradisa 2, IT-56124 Pisa, Italy
  • ,
  • Claudio Vignali

      Affiliations

    • Division of Diagnostic and Interventional Radiology, Department of Oncology and Radiology, Cisanello University Hospital – Building No. 9, Via Paradisa 2, IT-56124 Pisa, Italy
  • ,
  • Elena Bozzi

      Affiliations

    • Division of Diagnostic and Interventional Radiology, Department of Oncology and Radiology, Cisanello University Hospital – Building No. 9, Via Paradisa 2, IT-56124 Pisa, Italy
  • ,
  • Clotilde Della Pina

      Affiliations

    • Division of Diagnostic and Interventional Radiology, Department of Oncology and Radiology, Cisanello University Hospital – Building No. 9, Via Paradisa 2, IT-56124 Pisa, Italy
  • ,
  • Irene Bargellini

      Affiliations

    • Division of Diagnostic and Interventional Radiology, Department of Oncology and Radiology, Cisanello University Hospital – Building No. 9, Via Paradisa 2, IT-56124 Pisa, Italy
  • ,
  • Dania Cioni

      Affiliations

    • Division of Diagnostic and Interventional Radiology, Department of Oncology and Radiology, Cisanello University Hospital – Building No. 9, Via Paradisa 2, IT-56124 Pisa, Italy
  • ,
  • Filippo Oliveri

      Affiliations

    • Division of Hepatology, Department of Liver Transplantation, Hepatology, and Infectious Diseases, Cisanello University Hospital, Via Paradisa 2, IT-56124 Pisa, Italy
  • ,
  • Paolo De Simone

      Affiliations

    • Division of Liver Transplantation, Department of Liver Transplantation, Hepatology, and Infectious Diseases, Cisanello University Hospital, Via Paradisa 2, IT-56124 Pisa, Italy
  • ,
  • Carlo Bartolozzi

      Affiliations

    • Division of Diagnostic and Interventional Radiology, Department of Oncology and Radiology, Cisanello University Hospital – Building No. 9, Via Paradisa 2, IT-56124 Pisa, Italy
  • ,
  • Maurizia Brunetto

      Affiliations

    • Division of Hepatology, Department of Liver Transplantation, Hepatology, and Infectious Diseases, Cisanello University Hospital, Via Paradisa 2, IT-56124 Pisa, Italy
  • ,
  • Franco Filipponi

      Affiliations

    • Division of Liver Transplantation, Department of Liver Transplantation, Hepatology, and Infectious Diseases, Cisanello University Hospital, Via Paradisa 2, IT-56124 Pisa, Italy

Received 27 December 2007 ,Revised 1 March 2008 ,Accepted 26 March 2008.

References 

  1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108
  2. Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol. 2001;35:421–430
  3. Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology. 2005;42:1208–1236
  4. Llovet JM, Schwartz M, Mazzaferro V. Resection and liver transplantation for hepatocellular carcinoma. Semin Liver Dis. 2005;25:181–200
  5. Llovet JM, Fuster J, Bruix J. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation. Hepatology. 1999;30:1434–1440
  6. Lencioni R, Allgaier HP, Cioni D, Olschewski M, Deibert P, Crocetti L, et al. Small hepatocellular carcinoma in cirrhosis: randomized comparison of radiofrequency thermal ablation versus percutaneous ethanol injection. Radiology. 2003;228:235–240
  7. Lin SM, Lin CJ, Lin CC, Hsu CW, Chen YC. Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma < or =4cm. Gastroenterology. 2004;127:1714–1723
  8. Shiina S, Teratani T, Obi S, Sato S, Tateishi R, Fujishima T, et al. A randomized controlled trial of radiofrequency ablation versus ethanol injection for small hepatocellular carcinoma. Gastroenterology. 2005;129:122–130
  9. Lu DS, Yu NC, Raman SS, Limanond P, Lassman C, Murray K, et al. Radiofrequency ablation of hepatocellular carcinoma: treatment success as defined by histologic examination of the explanted liver. Radiology. 2005;234:954–960
  10. Goldberg SN, Girnan GD, Lukyanov AN, Ahmed M, Monsky WL, Gazelle GS, et al. Percutaneous tumor ablation: increased necrosis with combined radio-frequency ablation and intravenous liposomal doxorubicin in a rat breast tumor model. Radiology. 2002;222:797–804
  11. Ahmed M, Liu Z, Lukyanov AN, Signoretti S, Horkan C, Monsky WL, et al. Combination radiofrequency ablation with intratumoral liposomal doxorubicin: effect on drug accumulation and coagulation in multiple tissues and tumor types in animals. Radiology. 2005;235:469–477
  12. Varela M, Real MI, Burrel M, Forner A, Sala M, Brunet M, et al. Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J Hepatol. 2007;46:474–481
  13. Poon RT, Tso WK, Pang RW, Ng KK, Woo R, Tai KS, et al. A phase I/II trial of chemoembolization for hepatocellular carcinoma using a novel intra-arterial drug-eluting bead. Clin Gastroenterol Hepatol. 2007;5:1100–1108
  14. Goldberg SN, Charboneau JW, Dodd GD III, Dupuy DE, Gervais DA, Gillams AR, et al. Image-guided tumor ablation: proposal for standardization of terms and reporting criteria. Radiology. 2003;228:335–345
  15. Lencioni R, Cioni D, Crocetti L, Franchini C, Pina CD, Lera J, et al. Early-stage hepatocellular carcinoma in cirrhosis: long-term results of percutaneous image-guided radiofrequency ablation. Radiology. 2005;234:961–967
  16. Tateishi R, Shiina S, Teratani T, Obi S, Sato S, Koike Y, et al. Percutaneous radiofrequency ablation for hepatocellular carcinoma. Cancer. 2005;103:1201–1209
  17. Cabassa P, Donato F, Simeone F, Grazioli L, Romanini L. Radiofrequency ablation of hepatocellular carcinoma: long-term experience with expandable needle electrodes. AJR Am J Roentgenol. 2006;185:S316–S321
  18. Choi D, Lim HK, Rhim H, Kim YS, Lee WJ, Paik SW, et al. Percutaneous radiofrequency ablation for early-stage hepatocellular carcinoma as a first-line treatment: long-term results and prognostic factors in a large single-institution series. Eur Radiol. 2007;17:684–692
  19. Chen MS, Li JQ, Zheng Y, Guo RP, Liang HH, Zhang YQ, et al. A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma. Ann Surg. 2006;243:321–328
  20. Goldberg SN, Gazelle GS, Mueller PR. Thermal ablation therapy for focal malignancies: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. AJR Am J Roentgenol. 2000;174:323–331
  21. Goldberg SN, Hahn PF, Tanabe KK, Mueller PR, Schima W, Athanasoulis CA, et al. Percutaneous radiofrequency tissue ablation: does perfusion-mediated tissue cooling limit coagulation necrosis?. J Vasc Interv Radiol. 1998;9:101–111
  22. Rossi S, Garbagnati F, Lencioni R, Allgaier HP, Marchianò A, Fornari F, et al. Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply. Radiology. 2000;217:119–126
  23. Veltri A, Moretto P, Doriguzzi A, Pagano E, Carrara G, Gandini G, et al. Radiofrequency thermal ablation (RFA) after transarterial chemoembolization (TACE) as a combined therapy for unresectable non-early hepatocellular carcinoma (HCC). Eur Radiol. 2006;16:661–669
  24. Helmberger T, Dogan S, Straub G, Schrader A, Jüngst C, Reiser M, et al. Liver resection or combined chemoembolization and radiofrequency ablation improve survival in patients with hepatocellular carcinoma. Digestion. 2007;75:104–112
  25. Yamasaki T, Kurokawa F, Shirahashi H, Kusano N, Hironaka K, Okita K. Percutaneous radiofrequency ablation therapy for patients with hepatocellular carcinoma during occlusion of hepatic blood flow. Comparison with standard percutaneous radiofrequency ablation therapy. Cancer. 2002;95:2353–2360
  26. Lewis AL, Gonzales MV, Lloyd AW, Hall B, Tang Y, Willis SL, et al. DC bead: in vitro characterization of a drug-delivery device for transarterial chemoembolization. J Vasc Interv Radiol. 2006;17:335–342
  27. Sala M, Llovet JM, Vilana R, Bianchi L, Solé M, Ayuso C, et al. Initial response to percutaneous ablation predicts survival in patients with hepatocellular carcinoma. Hepatology. 2004;40:1352–1360

 The authors who have taken part in the research of this paper declared that they do not have a relationship with the manufacturers of the materials involved either in the past or present and they did not receive funding from the manufacturers to carry out their research.

PII: S0168-8278(08)00242-0

doi: 10.1016/j.jhep.2008.03.021

Journal of Hepatology
Volume 49, Issue 2 , Pages 217-222 , August 2008