Journal of Hepatology
Volume 49, Issue 5 , Pages 695-701 , November 2008

Analysis of hepatitis B genotype changes in chronic hepatitis B infection: Influence of antiviral therapy

  • Rosendo Jardi

      Affiliations

    • Department of Biochemistry, Hospital General Universitario Vall d’Hebrón, Paseo Valle Hebrón s/n, Servicio de Bioquimica, Barcelona 08035, Spain
    • Department of Hepatology, Hospital Universitario Vall d’Hebron, Barcelona, Spain
    • Corresponding Author InformationCorresponding author. Fax: +34 93 2746831.
    • ,
  • Francisco Rodriguez-Frias

      Affiliations

    • Department of Biochemistry, Hospital General Universitario Vall d’Hebrón, Paseo Valle Hebrón s/n, Servicio de Bioquimica, Barcelona 08035, Spain
    • Department of Hepatology, Hospital Universitario Vall d’Hebron, Barcelona, Spain
    • ,
  • Melanie Schaper

      Affiliations

    • Department of Biochemistry, Hospital General Universitario Vall d’Hebrón, Paseo Valle Hebrón s/n, Servicio de Bioquimica, Barcelona 08035, Spain
    • Department of Hepatology, Hospital Universitario Vall d’Hebron, Barcelona, Spain
    • ,
  • Elena Giggi

      Affiliations

    • Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain
    • ,
  • David Tabernero

      Affiliations

    • Department of Hepatology, Hospital Universitario Vall d’Hebron, Barcelona, Spain
    • ,
  • Maria Homs

      Affiliations

    • Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain
    • ,
  • Rafael Esteban

      Affiliations

    • Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain
    • Department of Hepatology, Hospital Universitario Vall d’Hebron, Barcelona, Spain
    • ,
  • Maria Buti

      Affiliations

    • Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain
    • Department of Hepatology, Hospital Universitario Vall d’Hebron, Barcelona, Spain

Received 27 November 2007 ,Revised 13 March 2008 ,Accepted 31 March 2008.

References 

  1. Okamoto H, Tsuda F, Sakugawa H, Sastrosoewignjo RI, Imai M, Miyakawa Y, et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface subtype. J Gen Virol. 1988;69:2575–2583
  2. Norder H, Courouce AM, Magnius LO. Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology. 1994;198:489–503
  3. Stuyver L, De Gendt S, Van Geyt C, Zoulim F, Fried M, Schinazi RF, et al. A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J Gen Virol. 2000;81:67–74
  4. Arauz-Ruiz P, Norder H, Robertson BH, Magnius LO. Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J Gen Virol. 2002;83:2059–2073
  5. Norder H, Courouce AM, Coursaget P, Echevarria JM, Lee SD, Mushahwar IK, et al. Genetic diversity of hepatitis B virus strains derived worldwide: genotypes, subgenotypes, and HBsAg subtypes. Intervirology. 2004;47:289–309
  6. Lindh M, Andersson AS, Gusdal A. Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus large scale analysis using a new genotyping method. J Infect Dis. 1997;175:1285–1293
  7. Rodríguez–Frías F, Jardí R, Buti M, Schaper M, Hermosilla E, Valdes A, et al. Hepatitis B virus genotypes and G1896A precore mutation in 486 Spanish patients with acute and chronic HBV infection. J Virol Hepat. 2006;13:343–350
  8. Sanchez–Tapias JM, Costa J, Mas A, Bruguera M, Rodes J. Influence of hepatitis B virus genotype on the long-term outcome of chronic B in western patients. Gastroenterology. 2002;123:1848–1856
  9. Echevarría JM, Avellón A, Magnius LO. Molecular epidemiology of hepatitis B virus in Spain: identification of viral genotypes and prediction of antigenic subtypes by limited sequencing. J Med Virol. 2005;76:176–184
  10. Schaefer S. Hepatitis B virus taxonomy and hepatitis B virus genotypes. World J Gastroenterol. 2007;13:14–21
  11. Bartolomeusz A, Schaefer S. Hepatitis B virus genotypes: comparison of genotyping methods. Rev Med Virol. 2004;14:3–16
  12. Kato H, Ruzibakiev R, Yuldasheva N, Hegay T, Kurvanov F, Achundjanov B, et al. Hepatitis B virus genotypes in Uzbekistan and validity of two different systems for genotyping. J Med Virol. 2002;67:477–483
  13. Gerner PR, Friedt M, Oettinger R, Lausch E, Wirth S. The hepatitis B seroconversion to anti-HBe is frequently associated with HBV genotype changes and selection of pre S2-defective particles in chronically infected children. Virology. 1998;245:163–172
  14. Hannoun C, Krogsgaard K, Horal P, Lindh M. Genotype mixtures of hepatitis B virus in patients treated with interferon. J Infect Dis. 2002;186:752–759
  15. Jardi R, Rodriguez F, Buti M, Costa X, Cotrina M, Valdes A, et al. Quantitative detection of hepatitis B virus DNA in serum by a new rapid real-time PCR fluorescence PCR assay. J Viral Hepatol. 2001;8:465–471
  16. Jardi R, Rodriguez Frias F, Schaper M, Ruiz G, Elefsiniotis I, Esteban R, et al. Hepatitis B virus polymerase variants associated with entecavir drug resistance in treatment naïve patients. J Viral Hepat. 2007;14:835–840
  17. Sanchez LV, Maldonado M, Bastidas-Ramirez BE, Norder H, Panduro A. Genotypes and S-gene variability of Mexican hepatitis B virus strains. J Med Virol. 2002;68:24–32
  18. Kato H, Orito E, Gish RG, Bzowej N, Newsom M, Sugauchi F, et al. Hepatitis B e antigen in sera from individuals infected with hepatitis B virus of genotype G. Hepatology. 2002;35:922–929
  19. Chen BF, Kao JH, Liu CJ, Chen DS, Chen PJ. Genotypic dominance and novel recombinations in HBV genotype B and C co-infected intravenous drug users. J Med Virol. 2004;73:13–22
  20. Kao JH, Chen PJ, Lai MY, Chen DS. Acute exacerbations of chronic infection of hepatitis B virus. Hepatology. 2001;34:817–823
  21. Usuda S, Okamoto H, Tanaka T, Kidd-Ljunggren K, Holland PV, Miyakawa Y, et al. Differentiation of hepatitis B virus genotypes D and E by ELISA using monoclonal antibodies to epitopes on the preS2-region product. J Virol Methods. 2000;87:81–89
  22. Kato H, Orito E, Suguchi F, Ueda R, Koshizaka T, Yanaka S, et al. Frequent co-infection with hepatitis B virus strains of distinct genotypes detected by hybridization with type-specific probes immobilized on a solid-phase support. J Virol Methods. 2003;110:29–35
  23. Osiowy C, Giles E. Evaluation of the INNO-LIPA HBV genotyping assay for determination of hepatitis B virus genotype. J Clin Microbiol. 2003;41:5473–5477
  24. Chen BF, Chen PJ, Jow GM, Sablon E, Liu CJ, Chen DS, et al. High prevalence of mixed genotype infections in hepatitis B virus infected intravenous drug users. J Med Virol. 2004;74:536–542
  25. Toan NG, Song LH, Kremsner PG, Duy DN, Binh VQ, Koeberlein B, et al. Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam. Hepatology. 2006;43:1375–1384
  26. Liu CJ, Kao JH, Chen DS. Mixed hepatitis B virus genotype infections: the more, the Worse?. Hepatology. 2006;44:770
  27. Zöllner B, Petersen J, Schröter M, Laufs R, Schoder V, Feucht HH. 20-fold increase in risk of lamivudine resistance in hepatitis B virus subtype adw. Lancet. 2001;357:934–935
  28. Buti M, Elefsiniotis I, Jardi R, Vargas V, Rodriguez-Frias F, Schaper M, et al. Viral genotype and baseline load predict the response to adefovir treatment in lamivudine resistant chronic hepatitis B patients. J Hepatol. 2007;366–372
  29. Janssen HLA, Van Zonneveld M, Senturk H, Zeuzem S, Akarca US, Cakaloglu Y, et al. Pegylated interferon alfa 2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial. Lancet. 2005;365:123–129

☆ The authors declare that they do not have anything to disclose regarding funding from industries or conflict of interest with respect to this manuscript.

PII: S0168-8278(08)00244-4

doi: 10.1016/j.jhep.2008.03.030

Journal of Hepatology
Volume 49, Issue 5 , Pages 695-701 , November 2008

Article Tools

* Image Usage & Resolution