Journal of Hepatology
Volume 49, Issue 3 , Pages 323-328 , September 2008

Sexual transmission is associated with spontaneous HCV clearance in HIV-infected patients

  • Nathan J. Shores

      Affiliations

    • Division of Gastroenterology, Department of Medicine, Wake Forest University Health System, Winston-Salem, NC, USA
    • Corresponding Author InformationCorresponding author.
    • ,
  • Ivana Maida

      Affiliations

    • Istituto Malattie Infettive, University of Sassari, Italy
    • Infectious Diseases, Hospital Carlos III, Madrid, Spain
    • ,
  • Vincent Soriano

      Affiliations

    • Infectious Diseases, Hospital Carlos III, Madrid, Spain
    • ,
  • Marina Núňez

      Affiliations

    • Division of Infectious Disease, Department of Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA

Received 15 February 2008 ,Revised 17 March 2008 ,Accepted 5 April 2008.

References 

  1. Hoofnagle JH. Hepatitis C: the clinical spectrum of disease. Hepatology. 1997;26:15S–20S
  2. Alter MJ, Kruszon-Moran D, Nainan OV, McQuillan GM, Gao F, Moyer LA, et al. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med. 1999;341:556–562
  3. Fleming CA, Craven DE, Thornton D, Tumilty S, Nunes D. Hepatitis C virus and human immunodeficiency virus coinfection in an urban population: low eligibility for interferon treatment. Clin Infect Dis. 2003;36:97–100
  4. Grebely J, Conway B, Raffa JD, Lai C, Krajden M, Tyndall MW. Hepatitis C virus reinfection in injection drug users. Hepatology. 2006;44:1139–1145
  5. Melendez-Morales L, Konkle BA, Preiss L, Zhang M, Mathew P, Eyster ME, et al. Chronic hepatitis B and other correlates of spontaneous clearance of hepatitis C virus among HIV-infected people with hemophilia. Aids. 2007;21:1631–1636
  6. Mendes-Correa MC, Barone AA, Guastini C. Hepatitis C virus seroprevalence and risk factors among patients with HIV infection. Rev Inst Med Trop Sao Paulo. 2001;43:15–19
  7. Messick K, Sanders JC, Goedert JJ, Eyster ME. Hepatitis C viral clearance and antibody reactivity patterns in persons with haemophilia and other congenital bleeding disorders. Haemophilia. 2001;7:568–574
  8. Mussi AD, Pereira RA, Silva VD, Martins RM, Souto FJ. Epidemiological aspects of hepatitis C virus infection among HIV-infected individuals in Mato Grosso State, Central Brazil. Acta Trop. 2007;104:116–121
  9. Perez-Cano R, Fernandez-Gutierrez C, Lopez-Suarez A, Mira J, Giron-Gonzalez JA. Factors related to the chronicity and evolution of hepatitis C infection in patients co-infected by the human immunodeficiency virus. Clin Microbiol Infect. 2002;8:589–597
  10. Quarleri JF, Bolcic FM, Bouzas MB, Laufer N, Gomez Carrillo M, Mammana L, et al. HCV genotype distribution among HIV co-infected individuals in Argentina: relationship with host and viral factors. Acta Gastroenterol Latinoam. 2007;37:76–83
  11. Sherman KE, Rouster SD, Chung RT, Rajicic N. Hepatitis C virus prevalence among patients infected with human immunodeficiency virus: a cross-sectional analysis of the US adult AIDS clinical trials group. Clin Infect Dis. 2002;34:831–837
  12. Jauncey M, Micallef JM, Gilmour S, Amin J, White PA, Rawlinson W, et al. Clearance of hepatitis C virus after newly acquired infection in injection drug users. J Infect Dis. 2004;190:1270–1274
  13. Watanabe H, Saito T, Shinzawa H, Okumoto K, Hattori E, Adachi T, et al. Spontaneous elimination of serum hepatitis C virus (HCV) RNA in chronic HCV carriers: a population-based cohort study. J Med Virol. 2003;71:56–61
  14. Maida I, Soriano V, Ramos B, Rios P, Gonzalez-Lahoz J, Nunez M. Characteristics and prospects for hepatitis C therapy of an HIV–HCV coinfected population followed at a reference HIV center. HIV Clin Trials. 2005;6:329–336
  15. Micallef JM, Kaldor JM, Dore GJ. Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies. J Viral Hepatol. 2006;13:34–41
  16. Grebely J, Raffa JD, Lai C, Krajden M, Conway B, Tyndall MW. Factors associated with spontaneous clearance of hepatitis C virus among illicit drug users. Can J Gastroenterol. 2007;21:447–451
  17. Seal KH, Monto A, Dove L, Shen H, Vittinghoff E, Tracy D, et al. The association of human immunodeficiency virus infection with spontaneously resolved hepatitis C virus infection and level of viremia among injection drug users. Dig Dis Sci. 2007;52:3423–3430
  18. Zhang M, Rosenberg PS, Brown DL, Preiss L, Konkle BA, Eyster ME, et al. Correlates of spontaneous clearance of hepatitis C virus among people with hemophilia. Blood. 2006;107:892–897
  19. Morsica G, Bagaglio S, Ghezzi S, Lodrini C, Vicenzi E, Santagostino E, et al. Hepatitis C virus (HCV) coinfection in a cohort of HIV positive long-term non-progressors: possible protective effect of infecting HCV genotype on HIV disease progression. J Clin Virol. 2007;39:82–86
  20. Zeitoun JD, Mallet V, Chaix ML, Viard JP, Blanche S, Pol S. Stable recovery from HCV in HIV–HCV co-infection under antiretroviral therapy. J Clin Virol. 2007;40:71–73
  21. Matthews GV, Hellard M, Kaldor J, Lloyd A, Dore GJ. Further evidence of HCV sexual transmission among HIV-positive men who have sex with men: response to Danta et al. Aids. 2007;21:2112–2113
  22. Di Martino V, Rufat P, Boyer N, Renard P, Degos F, Martinot-Peignoux M, et al. The influence of human immunodeficiency virus coinfection on chronic hepatitis C in injection drug users: a long-term retrospective cohort study. Hepatology. 2001;34:1193–1199
  23. Pawlotsky JM, Chevaliez S, McHutchison JG. The hepatitis C virus life cycle as a target for new antiviral therapies. Gastroenterology. 2007;132:1979–1998
  24. Barth H, Liang TJ, Baumert TF. Hepatitis C virus entry: molecular biology and clinical implications. Hepatology. 2006;44:527–535
  25. Danta M, Brown D, Bhagani S, Pybus OG, Sabin CA, Nelson M, et al. Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. Aids. 2007;21:983–991
  26. van de Laar TJ, van der Bij AK, Prins M, Bruisten SM, Brinkman K, Ruys TA, et al. Increase in HCV incidence among men who have sex with men in Amsterdam most likely caused by sexual transmission. J Infect Dis. 2007;196:230–238
  27. Neaigus A, Gyarmathy VA, Zhao M, Miller M, Friedman SR, Des Jarlais DC. Sexual and other noninjection risks for HBV and HCV seroconversions among noninjecting heroin users. J Infect Dis. 2007;195:1052–1061
  28. Lissen E, Alter HJ, Abad MA, Torres Y, Perez-Romero M, Leal M, et al. Hepatitis C virus infection among sexually promiscuous groups and the heterosexual partners of hepatitis C virus infected index cases. Eur J Clin Microbiol Infect Dis. 1993;12:827–831
  29. Rai RR, Mathur A, Mathur D, Udawat HP, Nepalia S, Nijhawan S, et al. Prevalence of occult hepatitis B & C in HIV patients infected through sexual transmission. Trop Gastroenterol. 2007;28:19–23
  30. Yenigun A, Durupinar B. Decreased frequency of the HLA-DRB1*11 allele in patients with chronic hepatitis C virus infection. J Virol. 2002;76:1787–1789
  31. Thio CL, Thomas DL, Goedert JJ, Vlahov D, Nelson KE, Hilgartner MW, et al. Racial differences in HLA class II associations with hepatitis C virus outcomes. J Infect Dis. 2001;184:16–21
  32. Zavaglia C, Martinetti M, Silini E, Bottelli R, Daielli C, Asti M, et al. Association between HLA class II alleles and protection from or susceptibility to chronic hepatitis C. J Hepatol. 1998;28:1–7
  33. Cramp ME, Carucci P, Underhill J, Naoumov NV, Williams R, Donaldson PT. Association between HLA class II genotype and spontaneous clearance of hepatitis C viraemia. J Hepatol. 1998;29:207–213
  34. Zavaglia C, Bortolon C, Ferrioli G, Rho A, Mondazzi L, Bottelli R, et al. HLA typing in chronic type B, D and C hepatitis. J Hepatol. 1996;24:658–665
  35. Hohler T, Gerken G, Notghi A, Knolle P, Lubjuhn R, Taheri H, et al. MHC class II genes influence the susceptibility to chronic active hepatitis C. J Hepatol. 1997;27:259–264
  36. Ksiaa L, Ayed-Jendoubi S, Sfar I, Gorgi Y, Najjar HA, Abdallah TB, et al. Clearance and persistence of hepatitis C virus in a Tunisian population: association with HLA class I and class II. Viral Immunol. 2007;20:312–319

☆ The authors declare that they do not have anything to disclose regarding funding from industries or conflict of interest with respect to this manuscript.

PII: S0168-8278(08)00284-5

doi: 10.1016/j.jhep.2008.04.010

Journal of Hepatology
Volume 49, Issue 3 , Pages 323-328 , September 2008

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