Journal of Hepatology
Volume 50, Issue 2 , Pages 289-295, February 2009

Relapse of hepatitis B in HBeAg-negative chronic hepatitis B patients who discontinued successful entecavir treatment: The case for continuous antiviral therapy☆

  • Daniel Shouval

      Affiliations

    • Liver Unit, Hadassah – Hebrew University Hospital, Ein-Kerem, P.O. Box 12000, Jerusalem 91120, Israel
    • Corresponding Author InformationCorresponding author. Tel.: +972 2 6777 337; fax: +972 2 6420 338.
    • ,
  • Ching-Lung Lai

      Affiliations

    • Department of Medicine, University of Hong Kong, Hong Kong
    • ,
  • Ting-Tsung Chang

      Affiliations

    • Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    • ,
  • Hugo Cheinquer

      Affiliations

    • Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil
    • ,
  • Paul Martin

      Affiliations

    • Center for Liver Diseases, University of Miami, FL, USA
    • ,
  • Giampiero Carosi

      Affiliations

    • Spedali Civili, Clinica di Malattie Infettive e Tropicali, Brescia, Italy
    • ,
  • Steven Han

      Affiliations

    • Division of Digestive Disease, UCLA School of Medicine, LA, CA, USA
    • ,
  • Sabahattin Kaymakoglu

      Affiliations

    • Division of Gastroenterology, Istanbul University, Istanbul, Turkey
    • ,
  • Ricardo Tamez

      Affiliations

    • Bristol-Myers Squibb, Research & Development, Princeton, NJ, USA
    • ,
  • Joanna Yang

      Affiliations

    • Bristol-Myers Squibb, Research & Development, Wallingford, CT, USA
    • ,
  • Daniel Tenney

      Affiliations

    • Bristol-Myers Squibb, Research & Development, Wallingford, CT, USA
    • ,
  • Helena Brett-Smith

      Affiliations

    • Bristol-Myers Squibb, Research & Development, Wallingford, CT, USA

Received 1 April 2008; received in revised form 20 August 2008; accepted 24 October 2008. published online 19 November 2008.

Associate Editor: G.K.K. Lau

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☆ (www.clinicaltrials.gov identifier: NCT00035789). Grant Support: The study was sponsored by Bristol-Myers Squibb. The sponsor designed the study in collaboration with a panel of expert hepatologists. The sponsor also collected the data, monitored study conduct, performed the statistical analyses, and coordinated writing of the manuscript with all authors. Employees of Bristol-Myers Squibb: Ricardo Tamez: employee of Bristol-Myers Squibb, Research & Development, Princeton, NJ, USA, Joanna Yang: employee of Bristol-Myers Squibb, Research & Development, Wallingford, CT, USA, Daniel Tenney: employee of Bristol-Myers Squibb, Research & Development, Wallingford, CT, USA, Helena Brett-Smith: employee of Bristol-Myers Squibb, Research & Development, Wallingford, CT, USA. Financial Disclosure Information: Daniel Shouval: BMS: grant support, Ching-Lung Lai: Investigator: BMS, LG Lifesciences; Advisory Board: BMS, Idenix Pharmaceuticals, GSK; Speaker Bureau: BMS; Unrestricted grant: BMS, Ting-Tsung Chang: Nothing to disclose, Hugo Cheinquer: BMS consultant, Paul Martin: BMS: consultant, speaker, investigator, Giampiero Carosi: Nothing to disclose, Steven Han: BMS: consultant, speakers bureau and research grant, Sabahattin Kaymakoglu. Nothing to disclose.

PII: S0168-8278(08)00715-0

doi:10.1016/j.jhep.2008.10.017

Journal of Hepatology
Volume 50, Issue 2 , Pages 289-295, February 2009

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