Journal of Hepatology
Volume 50, Issue 4 , Pages 719-728 , April 2009

Antiviral therapy increases the risk of bacterial infections in HCV-infected cirrhotic patients awaiting liver transplantation: A retrospective study

  • Jose A. Carrión

      Affiliations

    • Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Ciberehd and IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    • ,
  • Eva Martínez-Bauer

      Affiliations

    • Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Ciberehd and IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    • ,
  • Gonzalo Crespo

      Affiliations

    • Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Ciberehd and IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    • ,
  • Santseharay Ramírez

      Affiliations

    • Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Ciberehd and IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    • ,
  • Sofia Pérez-del-Pulgar

      Affiliations

    • Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Ciberehd and IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    • ,
  • Juan Carlos García-Valdecasas

      Affiliations

    • Liver Transplantation and Liver Surgery Department, Hospital Clinic, IDIBAPS; University of Barcelona, Barcelona, Spain
    • ,
  • Miquel Navasa

      Affiliations

    • Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Ciberehd and IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    • ,
  • Xavier Forns

      Affiliations

    • Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Ciberehd and IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +93 227 54 99; fax: +93 451 55 22.

Received 10 September 2008 ,Revised 5 November 2008 ,Accepted 6 November 2008.

References 

  1. Garcia-Retortillo M, Forns X, Feliu A, Moitinho E, Costa J, Navasa M, et al. Hepatitis C virus kinetics during and immediately after liver transplantation. Hepatology. 2002;35:680–687
  2. Berenguer M, Ferrell L, Watson J, Prieto M, Kim M, Rayon M, et al. HCV-related fibrosis progression following liver transplantation: increase in recent years. J Hepatol. 2000;32:673–684
  3. Garcia-Retortillo M, Forns X, Llovet JM, Navasa M, Feliu A, Massaguer A, et al. Hepatitis C recurrence is more severe after living donor compared to cadaveric liver transplantation. Hepatology. 2004;40:699–707
  4. Forman LM, Lewis JD, Berlin JA, Feldman HI, Lucey MR. The association between hepatitis C infection and survival after orthotopic liver transplantation. Gastroenterology. 2002;122:889–896
  5. Everson GT. Treatment of patients with hepatitis C virus on the waiting list. Liver Transpl. 2003;9:S90–S94
  6. Forns X, Garcia-Retortillo M, Serrano T, Feliu A, Suarez F, de la Mata M, et al. Antiviral therapy of patients with decompensated cirrhosis to prevent recurrence of hepatitis C after liver transplantation. J Hepatol. 2003;39:389–396
  7. Everson GT, Trotter J, Forman L, Kugelmas M, Halprin A, Fey B, et al. Treatment of advanced hepatitis C with a low accelerating dosage regimen of antiviral therapy. Hepatology. 2005;42:255–262
  8. Nevens F, Goubau P, Van Eyken P, Desmyter J, Desmet V, Fevery J. Treatment of decompensated viral hepatitis B-induced cirrhosis with low doses of interferon alpha. Liver. 1993;13:15–19
  9. Crippin JS, McCashland T, Terrault N, Sheiner P, Charlton MR. A pilot study of the tolerability and efficacy of antiviral therapy in hepatitis C virus-infected patients awaiting liver transplantation. Liver Transpl. 2002;8:350–355
  10. Iacobellis A, Siciliano M, Perri F, Annicchiarico BE, Leandro G, Caruso N, et al. Peginterferon alfa-2b and ribavirin in patients with hepatitis C virus and decompensated cirrhosis: a controlled study. J Hepatol. 2007;46:206–212
  11. Fernandez J, Navasa M, Planas R, Montoliu S, Monfort D, Soriano G, et al. Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis. Gastroenterology. 2007;133:818–824
  12. Navasa M, Forns X. Antiviral therapy in HCV decompensated cirrhosis: to treat or not to treat?. J Hepatol. 2007;46:185–188
  13. Fernandez J, Navasa M, Gomez J, Colmenero J, Vila J, Arroyo V, et al. Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology. 2002;35:140–148
  14. Rimola A, Garcia-Tsao G, Navasa M, Piddock LJ, Planas R, Bernard B, et al. Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. International Ascites Club. J Hepatol. 2000;32:142–153
  15. Prieto M, Berenguer M, Rayon JM, Cordoba J, Arguello L, Carrasco D, et al. High incidence of allograft cirrhosis in hepatitis C virus genotype 1b infection following transplantation: relationship with rejection episodes. Hepatology. 1999;29:250–256
  16. Berenguer M, Prieto M, Rayon JM, Mora J, Pastor M, Ortiz V, et al. Natural history of clinically compensated hepatitis C virus-related graft cirrhosis after liver transplantation. Hepatology. 2000;32:852–858
  17. Charlton M, Wiesner R. Natural history and management of hepatitis C infection after liver transplantation. Semin Liver Dis. 2004;24:79–88
  18. Berenguer M. Systematic review of the treatment of established recurrent hepatitis C with pegylated interferon in combination with ribavirin. J Hepatol. 2008;49:274–287
  19. Berenguer M, Palau A, Aguilera V, Rayon JM, Juan FS, Prieto M. Clinical benefits of antiviral therapy in patients with recurrent hepatitis C following liver transplantation. Am J Transplant. 2008;8:679–687
  20. Carrion JA, Navasa M, Garcia-Retortillo M, Garcia-Pagan JC, Crespo G, Bruguera M, et al. Efficacy of antiviral therapy on hepatitis C recurrence after liver transplantation: a randomized controlled study. Gastroenterology. 2007;132:1746–1756
  21. Samuel D, Bizollon T, Feray C, Roche B, Ahmed SN, Lemonnier C, et al. Interferon-alpha 2b plus ribavirin in patients with chronic hepatitis C after liver transplantation: a randomized study. Gastroenterology. 2003;124:642–650
  22. Samuel D. Antiviral treatment of recurrent hepatitis C after liver transplantation: the need for a multifaceted approach. Hepatology. 2005;41:436–438
  23. Samuel D, Forns X, Berenguer M, Trautwein C, Burroughs A, Rizzetto M, et al. Report of the monothematic EASL conference on liver transplantation for viral hepatitis (Paris, France, January 12–14, 2006). J Hepatol 2006;45:127–43.
  24. Narayanan Menon KV, Poterucha JJ, El-Amin OM, Burgart LJ, Kremers WK, Rosen CB, et al. Treatment of posttransplantation recurrence of hepatitis C with interferon and ribavirin: lessons on tolerability and efficacy. Liver Transpl. 2002;8:623–629
  25. Ramirez S, Massaguer A, Carrion JA, Costa J, Sanchez-Tapias J, Fontdevila C, et al. Hepatitis C virus compartmentalization and infection recurrence after liver transplantation J Hepatol 2007[Abstract];46:S16.
  26. Navasa M, Rodes J. Bacterial infections in cirrhosis. Liver Int. 2004;24:277–280
  27. Cirera I, Bauer TM, Navasa M, Vila J, Grande L, Taura P, et al. Bacterial translocation of enteric organisms in patients with cirrhosis. J Hepatol. 2001;34:32–37
  28. Navarini AA, Recher M, Lang KS, Georgiev P, Meury S, Bergthaler A, et al. Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses. Proc Natl Acad Sci USA. 2006;103:15535–15539

☆ X.F. has unrestricted grant support from Schering-Plough and Roche. The authors who have taken part in the research of this paper declared that they did not receive funding from the manufacturers of the drugs involved for this study.

PII: S0168-8278(08)00853-2

doi: 10.1016/j.jhep.2008.11.015

Journal of Hepatology
Volume 50, Issue 4 , Pages 719-728 , April 2009

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