Journal of Hepatology
Volume 51, Issue 3 , Pages 606-609 , September 2009

Unravelling the importance of microRNAs during hepatitis C virus infection in the human liver

  • Sébastien Pfeffer

      Affiliations

    • Architecture et Réactivité de l’ARN, Université de Strasbourg, Institut de biologie moléculaire et cellulaire du CNRS, 15 rue René Descartes, 67084 Strasbourg Cedex, France
    • Corresponding Author InformationCorresponding authors. Tel.: +33 3 88417060; fax: +33 3 88602218 (S. Pfeffer), Tel.: +33 3 90243703; fax: +33 3 90243710 (T.F. Baumert).
    • ,
  • Thomas F. Baumert

      Affiliations

    • Unité Inserm U748, Université de Strasbourg, 3 rue Koeberlé, 67000 Strasbourg, France
    • Service d’Hépatogastroentérologie, Nouvel Hôpital Civil, 1 Place de l’Hôpital, 67091 Strasbourg Cedex, France
    • Corresponding Author InformationCorresponding authors. Tel.: +33 3 88417060; fax: +33 3 88602218 (S. Pfeffer), Tel.: +33 3 90243703; fax: +33 3 90243710 (T.F. Baumert).

  • Image Result

    (A) Simplified model of miRNA biogenesis in animals. Pol, Polymerase; DGCR8, DiGeorge Critical syndrome Region 8; Exp, Exportin; TRBP, Tat-Responsive element Binding Protein; Ago, Argonaute. (B) Summa

    (A) Simplified model of miRNA biogenesis in animals. Pol, Polymerase; DGCR8, DiGeorge Critical syndrome Region 8; Exp, Exportin; TRBP, Tat-Responsive element Binding Protein; Ago, Argonaute. (B) Summary of known interactions of miRNAs with HCV RNA and the effect of interferon on their expression in vitro and in vivo. The expression of miR-199* does not seem to be controlled by interferon and is not discussed in this manuscript. Effects of IFN-α and β on miRNAs expression in cell culture models and HCV infection in vivo are indicated. (C) Association of liver pretreatment miR-122 levels with outcome of treatment based on pegylated interferon-α and ribavirin in patients with chronic hepatitis C as shown by Sarasin-Filipowicz et al. [9].

☆ The authors who have taken part in this study declared that they do not have anything to disclose regarding funding from industry or conflict of interest with respect to this manuscript.

PII: S0168-8278(09)00166-4

doi: 10.1016/j.jhep.2009.03.018

Journal of Hepatology
Volume 51, Issue 3 , Pages 606-609 , September 2009

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