Journal of Hepatology
Volume 51, Issue 3 , Pages 606-609 , September 2009

Unravelling the importance of microRNAs during hepatitis C virus infection in the human liver

  • Sébastien Pfeffer

      Affiliations

    • Architecture et Réactivité de l’ARN, Université de Strasbourg, Institut de biologie moléculaire et cellulaire du CNRS, 15 rue René Descartes, 67084 Strasbourg Cedex, France
    • Corresponding Author InformationCorresponding authors. Tel.: +33 3 88417060; fax: +33 3 88602218 (S. Pfeffer), Tel.: +33 3 90243703; fax: +33 3 90243710 (T.F. Baumert).
    • ,
  • Thomas F. Baumert

      Affiliations

    • Unité Inserm U748, Université de Strasbourg, 3 rue Koeberlé, 67000 Strasbourg, France
    • Service d’Hépatogastroentérologie, Nouvel Hôpital Civil, 1 Place de l’Hôpital, 67091 Strasbourg Cedex, France
    • Corresponding Author InformationCorresponding authors. Tel.: +33 3 88417060; fax: +33 3 88602218 (S. Pfeffer), Tel.: +33 3 90243703; fax: +33 3 90243710 (T.F. Baumert).

References 

  1. Ding SW, Voinnet O. Antiviral immunity directed by small RNAs. Cell. 2007;130:413–426
  2. Cullen BR. Is RNA interference involved in intrinsic antiviral immunity in mammals?. Nat Immunol. 2006;7:563–567
  3. Pfeffer S, Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, et al. Identification of virus-encoded microRNAs. Science. 2004;304:734–736
  4. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281–297
  5. Lecellier CH, Dunoyer P, Arar K, Lehmann-Che J, Eyquem S, Himber C, et al. A cellular microRNA mediates antiviral defense in human cells. Science. 2005;308:557–560
  6. Otsuka M, Jing Q, Georgel P, New L, Chen J, Mols J, et al. Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity. 2007;27:123–134
  7. Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science. 2005;309:1577–1581
  8. Pedersen IM, Cheng G, Wieland S, Volinia S, Croce CM, Chisari FV, et al. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature. 2007;449:919–922
  9. Sarasin-Filipowicz M, Krol J, Markiewicz I, Heim MH, Filipowicz W. Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy. Nat Med. 2009;15:31–33
  10. Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, et al. Silencing of microRNAs in vivo with ‘antagomirs’. Nature. 2005;438:685–689
  11. Asselah T, Bieche I, Narguet S, Sabbagh A, Laurendeau I, Ripault MP, et al. Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C. Gut. 2008;57:516–524
  12. Sarasin-Filipowicz M, Oakeley EJ, Duong FH, Christen V, Terracciano L, Filipowicz W, et al. Interferon signaling and treatment outcome in chronic hepatitis C. Proc Natl Acad Sci USA. 2008;105:7034–7039

☆ The authors who have taken part in this study declared that they do not have anything to disclose regarding funding from industry or conflict of interest with respect to this manuscript.

PII: S0168-8278(09)00166-4

doi: 10.1016/j.jhep.2009.03.018

Journal of Hepatology
Volume 51, Issue 3 , Pages 606-609 , September 2009

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