Journal of Hepatology
Volume 51, Issue 1 , Pages 176-186 , July 2009

Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet

  • Igor P. Pogribny

      Affiliations

    • Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 870 543 7096; fax: +1 870 543 7720.
    • ,
  • Volodymyr P. Tryndyak

      Affiliations

    • Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    • ,
  • Tetyana V. Bagnyukova

      Affiliations

    • Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    • ,
  • Stepan Melnyk

      Affiliations

    • Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    • ,
  • Beverly Montgomery

      Affiliations

    • Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    • ,
  • Sharon A. Ross

      Affiliations

    • Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA
    • ,
  • John R. Latendresse

      Affiliations

    • Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR, USA
    • ,
  • Ivan Rusyn

      Affiliations

    • Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, USA
    • ,
  • Frederick A. Beland

      Affiliations

    • Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA

Received 11 December 2008 ,Revised 15 February 2009 ,Accepted 2 March 2009.

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☆ The authors who have taken part in this study declared that they do not have anything to disclose regarding funding from industry or conflict of interest with respect to this manuscript. The views expressed in this paper do not necessarily represent those of the U.S. Food and Drug Administration.

PII: S0168-8278(09)00244-X

doi: 10.1016/j.jhep.2009.03.021

Journal of Hepatology
Volume 51, Issue 1 , Pages 176-186 , July 2009

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