Journal of Hepatology
Volume 51, Issue 4 , Pages 829-834, October 2009

Clevudine myopathy in patients with chronic hepatitis B☆

  • Byung Kook Kim

      Affiliations

    • Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul 143-729, Republic of Korea
    • These authors contributed equally to this work.
    • ,
  • Jeeyoung Oh

      Affiliations

    • Department of Neurology, Konkuk University School of Medicine, Seoul, Republic of Korea
    • These authors contributed equally to this work.
    • ,
  • So Young Kwon

      Affiliations

    • Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul 143-729, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 2 20305010; fax: +82 2 20305029.
    • ,
  • Won Hyeok Choe

      Affiliations

    • Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul 143-729, Republic of Korea
    • ,
  • Soon Young Ko

      Affiliations

    • Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul 143-729, Republic of Korea
    • ,
  • Kyoung Hoon Rhee

      Affiliations

    • Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul 143-729, Republic of Korea
    • ,
  • Tae Ho Seo

      Affiliations

    • Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul 143-729, Republic of Korea
    • ,
  • So Dug Lim

      Affiliations

    • Department of Pathology, Konkuk University School of Medicine, Seoul, Republic of Korea
    • ,
  • Chang Hong Lee

      Affiliations

    • Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul 143-729, Republic of Korea

Received 11 February 2009; received in revised form 23 March 2009; accepted 20 April 2009. published online 28 May 2009.

Associate Editor: G.K.K. Lau

Clevudine (l-FMAU) is a thymidine l-nucleoside analogue that was recently introduced for the treatment of chronic hepatitis B virus infection. Previous studies showed that clevudine has potent and sustained antiviral activity without causing viral resistance. No severe adverse event occurred during clinical trials. We describe two cases of drug-induced myopathy during long-term treatment of chronic hepatitis B with clevudine.

Abbreviations: l-FMAU, (1-(2-fluoro-5-methyl-β, l-arabinofuranosyl) uracil), HBV, hepatitis B virus, d-FMAU, (1-(2-fluoro-5-methyl-β, d-arabinofuranosyl) uracil), d-FIAU, (1-(2-deoxy-2-fluoro-β, d-arabinofuranosyl) iodouracil), ALT, alanine aminotransferase, EMG, electromyography, HCC, hepatocellular carcinoma, TACE, transarterial chemoembolization

Keywords: Clevudine, Hepatitis B, Adverse effects, Myopathy

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☆ The authors who have taken part in this study declared that they do not have a relationship with the manufactures of the drug involved either in the past or present and did not receive funding from the manufacturers to carry out their research.

PII: S0168-8278(09)00310-9

doi:10.1016/j.jhep.2009.04.019

Journal of Hepatology
Volume 51, Issue 4 , Pages 829-834, October 2009

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