Journal of Hepatology
Volume 51, Issue 4 , Pages 725-733 , October 2009

Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo

  • Pippa Newell

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • These authors contributed equally to this work.
    • ,
  • Sara Toffanin

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • Gastrointestinal Surgery and Liver Transplantation Unit, National Cancer Institute, IRCSS Foundation, Milan, Italy
    • These authors contributed equally to this work.
    • ,
  • Augusto Villanueva

      Affiliations

    • BCLC Group [HCC Translational Research Laboratory, Liver Unit, and Department of Pathology], IDIBAPS, CIBERehd, Hospital Clı´nic, Barcelona, Catalonia, Spain
    • ,
  • Derek Y. Chiang

      Affiliations

    • Department of Medical Oncology and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA, USA
    • Cancer Program, The Broad Institute of Harvard and MIT, Cambridge, MA, USA
    • ,
  • Beatriz Minguez

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • ,
  • Laia Cabellos

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • ,
  • Radoslav Savic

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • ,
  • Yujin Hoshida

      Affiliations

    • Cancer Program, The Broad Institute of Harvard and MIT, Cambridge, MA, USA
    • Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
    • ,
  • Kiat Hon Lim

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • ,
  • Pedro Melgar-Lesmes

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • ,
  • Steven Yea

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • ,
  • Judit Peix

      Affiliations

    • BCLC Group [HCC Translational Research Laboratory, Liver Unit, and Department of Pathology], IDIBAPS, CIBERehd, Hospital Clı´nic, Barcelona, Catalonia, Spain
    • ,
  • Kemal Deniz

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • ,
  • M. Isabel Fiel

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • ,
  • Swan Thung

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • ,
  • Clara Alsinet

      Affiliations

    • BCLC Group [HCC Translational Research Laboratory, Liver Unit, and Department of Pathology], IDIBAPS, CIBERehd, Hospital Clı´nic, Barcelona, Catalonia, Spain
    • ,
  • Victoria Tovar

      Affiliations

    • BCLC Group [HCC Translational Research Laboratory, Liver Unit, and Department of Pathology], IDIBAPS, CIBERehd, Hospital Clı´nic, Barcelona, Catalonia, Spain
    • ,
  • Vincenzo Mazzaferro

      Affiliations

    • Gastrointestinal Surgery and Liver Transplantation Unit, National Cancer Institute, IRCSS Foundation, Milan, Italy
    • ,
  • Jordi Bruix

      Affiliations

    • BCLC Group [HCC Translational Research Laboratory, Liver Unit, and Department of Pathology], IDIBAPS, CIBERehd, Hospital Clı´nic, Barcelona, Catalonia, Spain
    • ,
  • Sasan Roayaie

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • ,
  • Myron Schwartz

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • ,
  • Scott L. Friedman

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • ,
  • Josep M. Llovet

      Affiliations

    • Mount Sinai Liver Cancer Program (Divisions of Liver Diseases and Hemato/Oncology; Department of Medicine; Surgical Oncology, Department of Surgery; Department of Pathology), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    • BCLC Group [HCC Translational Research Laboratory, Liver Unit, and Department of Pathology], IDIBAPS, CIBERehd, Hospital Clı´nic, Barcelona, Catalonia, Spain
    • Institució Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +1 212 6599503; fax: +1 2128492574.

Received 4 February 2009 ,Revised 4 March 2009 ,Accepted 16 March 2009.

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☆ This study was partially supported by a research grant from Bayer Pharmaceuticals to J.M.L. J.B. and J.M.L. are consultants for Bayer Pharmaceuticals. NIH funded study (1RO1DK37340-23 and 1R01DK076986-01).

PII: S0168-8278(09)00321-3

doi: 10.1016/j.jhep.2009.03.028

Journal of Hepatology
Volume 51, Issue 4 , Pages 725-733 , October 2009

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