Journal of Hepatology
Volume 51, Issue 3 , Pages 581-592 , September 2009

Control of cccDNA function in hepatitis B virus infection

  • Massimo Levrero

      Affiliations

    • Department of Internal Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 0061 Rome, Italy
    • Oncogenomic Center, Andrea Cesalpino Foundation, Laboratory of Gene Expression, Regina Elena Cancer Institute, Rome, Italy
    • Laboratory of Gene Expression, Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 06 52662601, +39 06 49970892; fax: +39 06 49383333.
    • ,
  • Teresa Pollicino

      Affiliations

    • Department of Internal Medicine, Unit of Clinical and Molecular Hepatology, University Hospital of Messina, Messina, Italy
    • ,
  • Jorg Petersen

      Affiliations

    • Liver Centre Hamburg, IFI Institute for Interdisciplinary Medicine at Asclepius Klinik S. Georg, Hamburg, Germany
    • ,
  • Laura Belloni

      Affiliations

    • Department of Gene Expression, Sapienza University of Rome, Rome, Italy
    • ,
  • Giovanni Raimondo

      Affiliations

    • Department of Internal Medicine, Unit of Clinical and Molecular Hepatology, University Hospital of Messina, Messina, Italy
    • ,
  • Maura Dandri

      Affiliations

    • Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  • Image Result

    HBV cccDNA in the viral life-cycle.

    HBV cccDNA in the viral life-cycle.

  • Image Result

    The cccDNA chromatin immuno-precipitation assay.

    The cccDNA chromatin immuno-precipitation assay.

  • Image Result

    Chromatin modifications and transcription. (Upper left panel) Schematic representation of nucleosomes. (Upper right panel) Type, site and function of known chromatin marks. Numbers within brackets ide

    Chromatin modifications and transcription. (Upper left panel) Schematic representation of nucleosomes. (Upper right panel) Type, site and function of known chromatin marks. Numbers within brackets identify the aminoacid residues involved in specific modifications. (Lower panel) Schematic representation of a nucleosome with the more frequent histone modifications.

  • Image Result
    Schematic representation of cccDNA-bound histones acetylation status and the recruitment of chromatin modifying enzymes onto the viral minichromosome in relation to viral replication and infection pha

    Schematic representation of cccDNA-bound histones acetylation status and the recruitment of chromatin modifying enzymes onto the viral minichromosome in relation to viral replication and infection phase .

☆ The authors who have taken part in this study declared that they do not have anything to disclose regarding funding from industry or conflict of interest with respect to this manuscript.

PII: S0168-8278(09)00389-4

doi: 10.1016/j.jhep.2009.05.022

Journal of Hepatology
Volume 51, Issue 3 , Pages 581-592 , September 2009

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