Journal of Hepatology
Volume 51, Issue 4 , Pages 632-634 , October 2009

Portal vein thrombosis: A predictable milestone in cirrhosis?

  • Juan Carlos Garcia-Pagan

      Affiliations

    • Hospital Clinic – Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives, IDIBAPS and Ciberehd, Villaroel 170, 08036 Barcelona, Spain
    • Corresponding Author InformationCorresponding author. Fax: +34 932279856.
    • ,
  • Dominique-Charles Valla

      Affiliations

    • Centre de Référence des Maladies Vasculaires du Foie, AP-HP, Hôpital Beaujon, Service d’Hépatologie, 92118 Clichy, France

References 

  1. Yerdel MA, Gunson B, Mirza D, Karayalcin K, Olliff S, Buckels J, et al. Portal vein thrombosis in adults undergoing liver transplantation: risk factors, screening, management, and outcome. Transplantation. 2000;69:1873–1881
  2. Nonami T, Yokoyama I, Iwatsuki S, Starzl TE. The incidence of portal vein thrombosis at liver transplantation. Hepatology. 1992;16:1195–1198
  3. Amitrano L, Guardascione MA, Brancaccio V, Margaglione M, Manguso F, Iannaccone L, et al. Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis. J Hepatol. 2004;40:736–741
  4. Amitrano L, Brancaccio V, Guardascione MA, Margaglione M, Sacco M, Martino R, et al. Portal vein thrombosis after variceal endoscopic sclerotherapy in cirrhotic patients: role of genetic thrombophilia. Endoscopy. 2002;34:535–538
  5. Amitrano L, Brancaccio V, Guardascione MA, Margaglione M, Iannaccone L, D’Andrea G, et al. Inherited coagulation disorders in cirrhotic patients with portal vein thrombosis. Hepatology. 2000;31:345–348
  6. Francoz C, Belghiti J, Vilgrain V, Sommacale D, Paradis V, Condat B, et al. Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation. Gut. 2005;54:691–697
  7. Erkan O, Bozdayi AM, Disibeyaz S, Oguz D, Ozcan M, Bahar K, et al. Thrombophilic gene mutations in cirrhotic patients with portal vein thrombosis. Eur J Gastroenterol Hepatol. 2005;17:339–343
  8. Mangia A, Villani MR, Cappucci G, Santoro R, Ricciardi R, Facciorusso D, et al. Causes of portal venous thrombosis in cirrhotic patients: the role of genetic and acquired factors. Eur J Gastroenterol Hepatol. 2005;17:745–751
  9. Zocco MA, Di Stasio E, De Cristofaro R, Novi M, Ainora ME, Ponziani F, et al. Thrombotic risk factors in patients with liver cirrhosis: Correlation with MELD scoring system and portal vein thrombosis development. J Hepatol. 2009;51:682–689
  10. Siringo S, Bolondi L, Gaiani S, Sofia S, Zironi G, Rigamonti A, et al. Timing of the first variceal hemorrhage in cirrhotic patients: prospective evaluation of Doppler flowmetry, endoscopy and clinical parameters. Hepatology. 1994;20:66–73
  11. Merkel C, Sacerdoti D, Bolognesi M, Bombonato G, Gatta A. Doppler sonography and hepatic vein catheterization in portal hypertension: assessment of agreement in evaluating severity and response to treatment. J Hepatol. 1998;28:622–630
  12. Bolognesi M, Sacerdoti D, Mescoli C, Bombonato G, Cillo U, Merenda R, et al. Different hemodynamic patterns of alcoholic and viral endstage cirrhosis: analysis of explanted liver weight, degree of fibrosis and splanchnic Doppler parameters. Scand J Gastroenterol. 2007;42:256–262
  13. Guyatt G. Determining prognosis and creating clinical decision rules. In:  Haynes B,  Sackett DL,  Guyatt G,  Tulliez M editor. Clinical epidemiology. 3rd ed.. Lippincott Williams & Wilkins; 2006;p. 323–355
  14. Gaiani S, Bolondi L, Li BS, Zironi G, Siringo S, Barbara L. Prevalence of spontaneous hepatofugal portal flow in liver cirrhosis. Clinical and endoscopic correlation in 228 patients. Gastroenterology. 1991;100:160–167
  15. Walker AP. Portal vein thrombosis: what is the role of genetics?. Eur J Gastroenterol Hepatol. 2005;17:705–707
  16. Bombeli T, Basic A, Fehr J. Prevalence of hereditary thrombophilia in patients with thrombosis in different venous systems. Am J Hematol. 2002;70:126–132
  17. Price DT, Ridker PM. Factor V Leiden mutation and the risks for thromboembolic disease: a clinical perspective. Ann Intern Med. 1997;127:895–903
  18. Wanless IR, Wong F, Blendis LM, Greig P, Heathcote EJ, Levy G. Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension. Hepatology. 1995;21:1238–1247
  19. Valla DC. Thrombosis and anticoagulation in liver disease. Hepatology. 2008;47:1384–1393
  20. Webster GJ, Burroughs AK, Riordan SM. Review article: portal vein thrombosis – new insights into aetiology and management. Aliment Pharmacol Ther. 2005;21:1–9
  21. Northup PG. Hypercoagulation in liver disease. Clin Liver Dis. 2009;13:109–116
  22. Tripodi A, Mannucci PM. Abnormalities of hemostasis in chronic liver disease: reappraisal of their clinical significance and need for clinical and laboratory research. J Hepatol. 2007;46:727–733
  23. Tripodi A, Salerno F, Chantarangkul V, Clerici M, Cazzaniga M, Primignani M, et al. Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests. Hepatology. 2005;41:553–558
  24. Valla DC, Condat B. Portal vein thrombosis in adults: pathophysiology, pathogenesis and management. J Hepatol. 2000;32:865–871
  25. Denninger MH, Chait Y, Casadevall N, Hillaire S, Guillin MC, Bezeaud A, et al. Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors. Hepatology. 2000;31:587–591
  26. Garcia-Pagan JC, De Gotardi A, Bosch J. Review article: the modern management of portal hypertension – primary and secondary prophylaxis of variceal bleeding in cirrhotic patients. Aliment Pharmacol Ther. 2008;28:178–186
  27. Bosch J, Mastai R, Kravetz D, Bruix J, Gaya J, Rigau J, et al. Effects of propranolol on azygos venous blood flow and hepatic and systemic hemodynamics in cirrhosis. Hepatology. 1984;4:1200–1205

☆ The authors who have taken part in this study declared that they do not have anything to disclose regarding funding or conflict of interest with respect to this manuscript.

PII: S0168-8278(09)00444-9

doi: 10.1016/j.jhep.2009.06.009

Journal of Hepatology
Volume 51, Issue 4 , Pages 632-634 , October 2009

Article Tools