Journal of Hepatology
Volume 51, Issue 3 , Pages 426-429 , September 2009

Infection and inflammation in liver failure: Two sides of the same coin

  • Raza Malik

      Affiliations

    • Liver Failure Group, Institute of Hepatology, University College London and Hospitals, 69-75 Chenies Mews, London WC1E 6HX, UK
    • Beth Israel Deaconess Medical Center; Harvard Medical School, Boston, MA, USA
    • ,
  • Rajeshwar P. Mookerjee

      Affiliations

    • Liver Failure Group, Institute of Hepatology, University College London and Hospitals, 69-75 Chenies Mews, London WC1E 6HX, UK
    • ,
  • Rajiv Jalan

      Affiliations

    • Liver Failure Group, Institute of Hepatology, University College London and Hospitals, 69-75 Chenies Mews, London WC1E 6HX, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 207 6796552.

References 

  1. Jalan R, Williams R. Acute-on-chronic liver failure: pathophysiological basis of therapeutic options. Blood Purif. 2002;20:252–261
  2. Cazzaniga M, Dionigi E, Gobbo G, Fioretti A, Monti V, Salerno F. The systemic inflammatory response syndrome in cirrhotic patients: Relationship with their in-hospital outcome. J Hepatol. 2009;51:475–482
  3. Cholongitas E, Senzolo M, Patch D, Kwong K, Nikolopoulou V, Leandro G, et al. Risk factors, sequential organ failure assessment and model for end-stage liver disease scores for predicting short term mortality in cirrhotic patients admitted to intensive care unit. Aliment Pharmacol Ther. 2006;23:883–893
  4. Mookerjee RP, Sen S, Davies NA, Hodges SJ, Williams R, Jalan R. Tumour necrosis factor α is an important mediator of portal and systemic haemodynamic derangements in alcoholic hepatitis. Gut. 2003;52:1182–1187
  5. Mookerjee RP, Dalton RN, Davies NA, Hodges SJ, Turner C, Williams R, et al. Inflammation is an important determinant of levels of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) in acute liver failure. Liver Transpl. 2007;13:400–405
  6. Zauner CA, Apsner RC, Kranz A, Kramer L, Madl C, Schneider B, et al. Outcome prediction for patients with cirrhosis of the liver in a medical ICU: a comparison of the APACHE scores and liver-specific scoring systems. Intensive Care Med. 1996;22:559–563
  7. Wehler M, Kokoska J, Reulbach U, Hahn EG, Strauss R. Short-term prognosis in critically ill patients with cirrhosis assessed by prognostic scoring systems. Hepatology. 2001;34:255–261
  8. Jalan R, Stadlbauer V, Sen S, Mookerjee RP, Davies N, Hodges S, et al. Natural history of acute decompensation of cirrhosis: the basis of the definition, prognosis and pathophysiology of acute on chronic liver failure. Hepatology. 2006;44(Suppl 1):371A
  9. Rolando N, Wade J, Davalos M, Wendon J, Philpott-Howard J, Williams R. The systemic inflammatory response syndrome in acute liver failure. Hepatology. 2000;32:734–739
  10. Vaquero J, Polson J, Chung C, Helenowski I, Schiodt FV, Reisch J, et al. Infection and the progression of hepatic encephalopathy in acute liver failure. Gastroenterology. 2003;125:755–764
  11. Leithead JA, Ferguson JW, Bates CM, Davidson JS, Lee A, Bathgate AJ, et al. The systemic inflammatory response syndrome is predictive of renal dysfunction in patients with non-paracetamol-induced acute liver failure. Gut. 2009;58:443–449
  12. Bernard B, Grangé JD, Khac EN, Amiot X, Opolon P, Poynard T. Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with ascites: a meta-analysis. Digestion. 1998;59(Suppl 2):54–57
  13. Thabut D, Massard J, Gangloff A, Carbonell N, Francoz C, Nguyen-Khac E, et al. Model for end-stage liver disease score and systemic inflammatory response are major prognostic factors in patients with cirrhosis and acute functional renal failure. Hepatology. 2007;46:1872–1882
  14. Jalan R, Mookerjee RP. Systemic hemodynamics, hepatic blood flow and portal pressure in patients with cirrhosis and multiorgan failure: the role of sympathetic activation. Hepatology. 2008;48(Suppl 1):1077A
  15. Mookerjee RP, Malaki M, Davies NA, Hodges SJ, Dalton RN, Turner C, et al. Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitis. Hepatology. 2007;45:62–71
  16. Stadlbauer V, Wright G, Banaji M, Mukhopadhyay A, Mookerjee R, Moore K, et al. Relationship between activation of the sympathetic nervous system and renal blood flow autoregulation in cirrhosis. Gastroenterology. 2008;134:111–119
  17. Shawcross DL, Davies NA, Williams R, Jalan R. Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol. 2004;40:247–254
  18. Pedersen HR, Ring-Larsen H, Olsen NV, Larsen FS. Hyperammonemia actssynergistically with lipopolysaccharide in inducing changes in cerebral hemodynamics in rats anaesthetised with pentobarbital. J Hepatol. 2007;47:245–252
  19. Jiang W, Desjardins P, Butterworth RF. Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia. J Cereb Blood Flow Metab. 2009;29:944–952
  20. Davies NA, Wright G, Shawcross D, Hodges S, Harry D, Mani AR, et al. Endotoxaemia induces brain swelling and produces coma in bile duct ligated rats. Hepatology. 2007;45:1517–1526
  21. Jalan R, Schnurr K, Mookerjee RP, Sen S, Cheshire L, Hodges S, et al. Alterations in the functional capacity of albumin in patients with decompensated cirrhosis is associated with increased mortality. Hepatology, in press.
  22. Sen S, Davies NA, Mookerjee R, Hodges S, Cheshire L, Williams R. Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled study. Liver Transpl. 2004;10:1109–1119
  23. Naveau S, Chollet-Martin S, Dharancy S, Mathurin P, Jouet P, Piquet MA, et al. Foie-alcool group of the association Française pour l’Etude du Foie. A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis. Hepatology. 2004;39:1390–1397
  24. Boetticher NC, Peine CJ, Kwo P, Abrams GA, Patel T, Aqel B, et al. A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis. Gastroenterology. 2008;135:1953–1960
  25. Stadlbauer V, Davies NA, Sen S, Jalan R. Liver support systems in the management of complications of cirrhosis. Semin Liver Dis. 2008;28:96–109
  26. Mookerjee RP, Stadlbauer V, Lidder S, Wright GA, Hodges SJ, Davies NA, et al. Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts outcome. Hepatology. 2007;46:831–840
  27. Tsai MH, Peng YS, Lien JM, Weng HH, Ho YP, Yang C, et al. Multiple organ system failure in critically ill cirrhotic patients. A comparison of two multiple organ dysfunction/failure scoring systems. Digestion. 2004;69:190–200

☆ The authors who have taken part in this study declared that they do not have anything to disclose regarding funding or conflict of interest with respect to this manuscript.

PII: S0168-8278(09)00451-6

doi: 10.1016/j.jhep.2009.06.013

Journal of Hepatology
Volume 51, Issue 3 , Pages 426-429 , September 2009

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