Journal of Hepatology
Volume 51, Issue 6 , Pages 1074-1081 , December 2009

Vinyl chloride and the liver

Received 20 August 2009 ,Revised 16 September 2009 ,Accepted 18 September 2009.

References 

  1. WHO. Vinyl chloride. Environmental health criteria 215. Geneva: World Health Organization; 1999.
  2. Tariff commission. Census of dyes and of other synthetic organic chemicals 1927. Tariff Information Series No. 37. Washington, DC 139: US Government Printing Office; 1928.
  3. ACGIH vinyl chloride. American conference of Governmental Industrial Hygienists. Cincinnati, OH; 2001.
  4. Dow chemical company, http://www.dow.com.productsafety/finder/vcm.htm; 2007 [accessed 14.08.09].
  5. Kauppinen T, Toikkanen J, Pedersen D, Young R, Ahrens W, Boffetta P, et al. Occupational exposure to carcinogens in the European Union. Occup Environ Med. 2000;57:10–18
  6. IARC working group on the evaluation of carcinogenic risks to humans. 1,3-Butadiene, ethylene oxide and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide) vinyl chloride. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 97; 2007. p. 311–443.
  7. Forman D, Bennett B, Stafford J, Doll R. Exposure to vinyl chloride and angiosarcoma of the liver: a report of the register of cases. Br J Ind Med. 1985;42:750–753
  8. Barnes AW. Vinyl chloride and the production of PVC. Proc R Soc Med. 1976;69:277–281
  9. Dobecki M, Romaniwicz B. Occupational exposure to toxic substances during the production of vinyl chloride and chlorinated organic solvents. Med Pr. 1993;44:99–102
  10. Hozo I, Andelinovic S, Ljutic D, Bojic L, Miric D, Giunio L. Two new cases of liver angiosarcoma: history and perspectives of liver angiosarcoma among plastic industry workers. Toxicol Ind Health. 1997;13:639–647
  11. Du CL, Chan CC, Wang JD. Comparison of personal and area sampling strategies in assessing workers’ exposure to vinyl chloride monomer. Bull Environ Contam Toxicol. 1996;56:534–542
  12. Bolt HM. Vinyl chloride – a classical industrial toxicant of new interest. Crit Rev Toxicol. 2005;35:307–323
  13. Marion MJ, Froment O, Trépo C. Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure. Mol Carcinog. 1991;4:450–454
  14. De Vivo I, Marion MJ, Smith SJ, Carney WP, Brandt-Rauf PW. Mutant c-Ki-ras p21 protein in chemical carcinogenesis in humans exposed to vinyl chloride. Cancer Causes Control. 1994;5:273–278
  15. Trivers GE, Cawley HL, DeBenedetti VM, Hollstein M, Marion MJ, Bennett WP, et al. Anti-p53 antibodies in sera of workers occupationally exposed to vinyl chloride. J Natl Cancer Inst. 1995;87:1400–1407
  16. Hollstein M, Marion MJ, Lehman T, Welsh J, Harris CC, Martel-Planche G, et al. P53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Carcinogenesis. 1994;15:1–3
  17. Luo JC, Liu HT, Cheng TJ, Du CL, Wang JD. Plasma Asp13-Ki-ras oncoprotein expression in vinyl chloride monomer workers in Taiwan. J Occup Environ Med. 1998;40:1053–1058
  18. Smith SJ, Li Y, Whitley R, Marion MJ, Partilo S, Carney WP, et al. Molecular epidemiology of p53 protein mutations in workers exposed to vinyl chloride. Am J Epidemiol. 1998;147:302–308
  19. Mocci F, Nettuno M. Plasma mutant-p53 protein and anti-p53 antibody as a marker: an experience in vinyl chloride workers in Italy. J Occup Environ Med. 2006;48:158–164
  20. Barbin A, Froment O, Boivin S, Marion MJ, Belpoggi F, Maltoni C, et al. P53 gene mutation pattern in rat liver tumors induced by vinyl chloride. Cancer Res. 1997;57:1695–1698
  21. Holmberg B, Kronevi T, Winell M. The pathology of vinyl chloride exposed mice. Acta Vet Scand. 1976;17:328–342
  22. Hong CB, Winston JM, Thornburg LP, Lee CC, Soods JS. Follow-up study on the carcinogenicity of vinyl chloride and vinylidene chloride in rats and mice: tumor incidence and mortality subsequent to exposure. J Toxicol Environ Health. 1981;7:909–924
  23. Maltoni C, Lefemine G, Ciliberti A, Cotti G, Carretti D. Carcinogenicity bioassays of vinyl chloride monomer: a model of risk assessment on an experimental basis. Environ Health Perspect. 1981;41:3–29
  24. Lee CC, Bhandari JC, Winston JM, House WB, Dixon RL, Woods JS. Carcinogenicity of vinyl chloride and vinylidene chloride. J Toxicol Environ Health. 1978;4:15–30
  25. Drew RT, Boorman GA, Haseman JK, McConnell EE, Busey WM, Moore JA. The effect of age and exposure duration on cancer induction by a known carcinogen in rats mice and hamsters. Toxicol Appl Pharmacol. 1983;68:120–130
  26. Feron VJ, Kroes R. One-year time-sequence inhalation toxicity study of vinyl chloride in rats. II. Morphological changes in the respiratory tract, ceruminous gland, brain, kidneys heart and spleen. Toxicology. 1979;13:131–141
  27. Feron VJ, Spit BJ, Immel HR, Kroes R. One-year time-sequence inhalation toxicity study of vinyl chloride in rats. III. Morphological changes in the liver. Toxicology. 1979;13:143–154
  28. Groth DH, Coate WB, Ulland BM, Hornung RW. Effects of aging on the induction of angiosarcoma. Environ Health Perspect. 1981;41:53–57
  29. Feron VJ, Hendriksen CFM, Speek AJ, Til HP, Spit BJ. Lifespan oral toxicity study of vinyl chloride in rats. Food Cosmet Toxicol. 1981;19:317–333
  30. Maltoni C, Cotti G. Carcinogenicity of vinyl chloride in Sprague–Dawley rats after prenatal and postnatal exposure. Ann NY Acad Sci. 1988;534:145–159
  31. Til HP, Feron VJ, Immel HR. Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem Toxicol. 1991;29:713–718
  32. Feron VJ, Kruysse A, Til HP. One-year time sequence inhalation toxicity study of vinyl chloride in rats. I. Growth, mortality, haematology, clinical chemistry and organ weights. Toxicology. 1979;13:25–28
  33. Thomas LB, Popper H, Berk PD, Selikoff I, Falk H. Vinyl-chloride-induced liver disease. From idiopathic portal hypertension (Banti’s syndrome) to angiosarcomas. N Engl J Med. 1975;292:17–22
  34. Popper H, Maltoni C, Selikoff IJ. Vinyl chloride-induced hepatic lesions in man and rodents. A comparison. Liver. 1981;1:7–20
  35. Tamburro CH, Makk L, Popper H. Early hepatic histologic alterations among chemical (vinyl monomer) workers. Hepatology. 1984;4:413–418
  36. Creech JL, Johnson MN. Angiosarcoma of liver in the manufacture of polyvinyl chloride. J Occup Med. 1974;16:150–151
  37. Lee FI, Smith PM, Bennett B, Williams DM. Occupationally related angiosarcoma of the liver in the United Kingdom 1972–1994. Gut. 1996;39:312–318
  38. Lelbach WK. A 25-year follow-up study of heavily exposed vinyl chloride workers in Germany. Am J Ind Med. 1996;29:446–458
  39. Mundt KA, Dell LD, Austin RP, Luippold RS, Noess R, Bigelow C. Historical cohort study of 10,109 men in the North American vinyl chloride industry, 1942–72: update of cancer mortality to 31 December 1995. Occup Environ Med. 2000;57:774–781
  40. Ward E, Boffetta P, Andersen A, Colin D, Comba P, Deddens JA, et al. Update of the follow-up of mortality and cancer incidence among European workers employed in the vinyl chloride industry. Epidemiology. 2001;12:710–718
  41. Boffetta P, Matisane L, Mundt KA, Dell LD. Meta-analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality. Scand J Work Environ Health. 2003;29:220–229
  42. Mastrangelo G, Fedeli U, Fadda E, Valentini F, Agnesi R, Magarotto G, et al. Increased risk of hepatocellular carcinoma and liver cirrhosis in vinyl chloride workers: synergistic effect of occupational exposure with alcohol intake. Environ Health Perspect. 2004;112:1188–1192
  43. Wong RH, Chen PC, Du CL, Wang JD, Cheng TJ. An increased standardised mortality ratio for liver cancer among polyvinyl chloride workers in Taiwan. Occup Environ Med. 2002;59:405–409
  44. Wong RH, Chen PC, Wang JD, Du CL, Cheng TJ. Interaction of vinyl chloride monomer exposure and hepatitis B viral infection on liver cancer. J Occup Environ Med. 2003;45:379–383
  45. Pirastu R, Baccini M, Biggeri A, Comba P. Epidemiological study of workers exposed to vinyl chloride in a Porto Marghera factory: mortality update. Epidemiol Prev. 2003;27:161–172
  46. Hsieh HI, Chen PC, Wong RH, Wang JD, Yang PM, Cheng TJ. Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers. Toxicology. 2007;239:34–44
  47. Hsiao TJ, Wang JD, Yang PM, Yang PC, Cheng TJ. Liver fibrosis in asymptomatic polyvinyl chloride workers. J Occup Environ Med. 2004;46:962–966
  48. Maroni M, Mocci F, Visentin S, Preti G, Fanetti AC. Periportal fibrosis and other liver ultrasonography findings in vinyl chloride workers. Occup Environ Med. 2003;60:60–65
  49. McLaughlin JK, Lipworth L. A critical review of the epidemiologic literature on health effects of occupational exposure to vinyl chloride. J Epidemiol Biostat. 1999;4:253–275
  50. Dragani TA, Zocchetti C. Occupational exposure to vinyl chloride and risk of hepatocellular carcinoma. Cancer Causes Control. 2008;19:1193–1200

☆ The author declared that he is a paid consultant to the European Council of Vinyl Manufacturer’s for the workshop on the relationship between VCM and HCC, a consultant to Bayer and a speaker for Bayer Inc.

PII: S0168-8278(09)00634-5

doi: 10.1016/j.jhep.2009.09.012

Journal of Hepatology
Volume 51, Issue 6 , Pages 1074-1081 , December 2009

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