Journal of Hepatology
Volume 52, Issue 1 , Pages 130-132 , January 2010

CD8+ T cells drive adipose tissue inflammation – A novel clue for NASH pathogenesis?

  • Yury Popov
    • ,
  • Detlef Schuppan

      Affiliations

    • Corresponding Author InformationCorresponding author. Address: Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Dana 501, 330 Brookline Ave., Boston, MA 02215, USA. Tel.: +1 617 6678377, +1 617 9755041; fax: +1 617 6672767.

References 

  1. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006;43:S99–S112
  2. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860–867
  3. Aithal GP, Thomas JA, Kaye PV, Lawson A, Ryder SD, Spendlove I, et al Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology. 2008;135:1176–1184
  4. Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, et al CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15:914–920
  5. Winer S, Chan Y, Paltser G, Truong D, Tsui H, Bahrami J, et al Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med. 2009;15:921–929
  6. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, et al Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009;15:930–939
  7. Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell. 2000;6:87–97
  8. Straus DS, Glass CK. Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol. 2007;28:551–558
  9. Rensen SS, Slaats Y, Nijhuis J, Jans A, Bieghs V, Driessen A, et al. Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis. Am J Pathol. 2009;
  10. Deng ZB, Liu Y, Liu C, Xiang X, Wang J, Cheng Z, et al. Immature myeloid cells induced by a high-fat diet contribute to liver inflammation. Hepatology. 2009;
  11. Safadi R, Ohta M, Alvarez CE, Fiel MI, Bansal M, Mehal WZ, et al. Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology. 2004;127:870–882

PII: S0168-8278(09)00665-5

doi: 10.1016/j.jhep.2009.10.019

Journal of Hepatology
Volume 52, Issue 1 , Pages 130-132 , January 2010

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