Journal of Hepatology
Volume 52, Issue 3 , Pages 355-361 , March 2010

Normal to increased thrombin generation in patients undergoing liver transplantation despite prolonged conventional coagulation tests

  • Ton Lisman

      Affiliations

    • Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • Corresponding Author InformationCorresponding author. Address: Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, BA44, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Tel.: +31 50 361 9028; fax: +31 50 363 2796.
    • These authors contributed equally.
    • ,
  • Kamran Bakhtiari

      Affiliations

    • Department of Experimental Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    • These authors contributed equally.
    • ,
  • Ilona T.A. Pereboom

      Affiliations

    • Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Herman G.D. Hendriks

      Affiliations

    • Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Joost C.M. Meijers

      Affiliations

    • Department of Experimental Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    • These authors contributed equally.
    • ,
  • Robert J. Porte

      Affiliations

    • Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • These authors contributed equally.

Received 20 July 2009 ,Revised 25 August 2009 ,Accepted 21 October 2009.

References 

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  3. Tripodi A, Salerno F, Chantarangkul V, Clerici M, Cazzaniga M, Primignani M, et al. Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests. Hepatology. 2005;41:553–558
  4. Lisman T, Leebeek FW, Mosnier LO, Bouma BN, Meijers JC, Janssen HL, et al. Thrombin-activatable fibrinolysis inhibitor deficiency in cirrhosis is not associated with increased plasma fibrinolysis. Gastroenterology. 2001;121:131–139
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  23. Tripodi A, Primignani M, Chantarangkul V, Clerici M, Dell’era A, Fabris F, et al. Thrombin generation in patients with cirrhosis: the role of platelets. Hepatology. 2006;44:440–445
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PII: S0168-8278(09)00802-2

doi: 10.1016/j.jhep.2009.12.001

Journal of Hepatology
Volume 52, Issue 3 , Pages 355-361 , March 2010

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