Journal of Hepatology
Volume 52, Issue 3 , Pages 340-347 , March 2010

The use of β-adrenergic drugs improves hepatic oxygen metabolism in cirrhotic patients undergoing liver resection

  • Pilar Taurà

      Affiliations

    • Department of Anesthesiology, Liver Surgery and Liver Transplant Unit, Hospital Clinic, Villarroel 170, Barcelona University, E-08036 Barcelona, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34 93 227 5558; fax: +34 93 227 5454.
    • ,
  • Josep Fuster

      Affiliations

    • Department of Surgery, Liver Surgery and Liver Transplant Unit, Hospital Clinic, Barcelona University, Barcelona, Spain
    • ,
  • Jordi Mercadal

      Affiliations

    • Department of Anesthesiology, Liver Surgery and Liver Transplant Unit, Hospital Clinic, Villarroel 170, Barcelona University, E-08036 Barcelona, Spain
    • ,
  • Graciela Martinez-Palli

      Affiliations

    • Department of Anesthesiology, Liver Surgery and Liver Transplant Unit, Hospital Clinic, Villarroel 170, Barcelona University, E-08036 Barcelona, Spain
    • ,
  • Constantino Fondevila

      Affiliations

    • Department of Surgery, Liver Surgery and Liver Transplant Unit, Hospital Clinic, Barcelona University, Barcelona, Spain
    • ,
  • Annabel Blasi

      Affiliations

    • Department of Anesthesiology, Liver Surgery and Liver Transplant Unit, Hospital Clinic, Villarroel 170, Barcelona University, E-08036 Barcelona, Spain
    • ,
  • Jaume Balust

      Affiliations

    • Department of Anesthesiology, Liver Surgery and Liver Transplant Unit, Hospital Clinic, Villarroel 170, Barcelona University, E-08036 Barcelona, Spain
    • ,
  • Juan-Carlos Garcia-Valdecasas

      Affiliations

    • Department of Surgery, Liver Surgery and Liver Transplant Unit, Hospital Clinic, Barcelona University, Barcelona, Spain

Received 15 April 2009 ,Revised 30 August 2009 ,Accepted 24 September 2009.

References 

  1. Mitsuta H, Ohdan H, Mizunuma K, Itamoto T, Asahara T. Near-infrared spectroscopic analysis of hepatic hemodynamics and oxygen metabolism after extensive hepatectomy. Med Sci Monit. 2004;10:BR356–BR361
  2. Kawasaki T, Moriyasu F, Kimura T, Someda H, Fukuda Y, Ozawa K. Changes in portal blood flow consequent to partial hepatectomy: Doppler estimation. Radiology. 1991;180:373–377
  3. Nanashima A, Shibasaki S, Sakamoto I, Sueyoshi E, Sumida Y, Abo T, et al. Clinical evaluation of magnetic resonance imaging flowmetry of portal and hepatic veins in patients following hepatectomy. Liver Int. 2006;26:587–594
  4. Fausto N, Campbell JS, Riehle KJ. Liver regeneration. Hepatology. 2006;43:S45–S53
  5. Taub R. Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol. 2004;5:836–847
  6. Seifter S, Englard S. Energy metabolism. In:  Arias IM,  Boyer JL,  Fausto N,  Jakoby WB,  Schachter D,  Shafritz DA editor. The liver: biology and pathobiology. 3rd ed.. New York: Raven Press; 1994;p. 323–364
  7. Guerrieri F, Muolo L, Cocco T, Capozza G, Turturro N, Cantatore P, et al. Correlation between rat liver regeneration and mitochondrial energy metabolism. Biochim Biophys Acta. 1995;1272:95–100
  8. Mann DV, Lam WW, Hjelm NM, So NM, Yeung DK, Metreweli C, et al. Human liver regeneration: hepatic energy economy is less efficient when the organ is diseased. Hepatology. 2001;34:557–565
  9. Yang S, Tan TM, Wee A, Leow CK. Mitochondrial respiratory function and antioxidant capacity in normal and cirrhotic livers following partial hepatectomy. Cell Mol Life Sci. 2004;61:220–229
  10. Nonami T, Asahi K, Harada A, Nakao A, Takagi H. Effect of hyperdynamic circulatory support on hepatic hemodynamics, oxygen supply and demand after massive hepatectomy. Surgery. 1991;109:277–283
  11. Nonami T. Systemic hemodynamics and oxygen metabolism after hepatectomy – effect of hyperdynamic systemic circulatory support on postoperative prognosis. Nippon Geka Gakkai Zasshi. 1985;86:148–159
  12. Kinoshita H, Yamazaki O, Sakai K, Hirohashi K, Kubo S, Iwasa R, et al. Measurement of portal blood flow in man by a continuous local thermodilution method. III. Effects of dopamine on systemic and portal hemodynamics after hepatectomy. Nippon Geka Gakkai Zasshi. 1989;90:556–565
  13. Kubo S, Tanaka H, Shuto T, Takemura S, Uenishi T, Tanaka S, et al. Hepatic failure after liver resection in patients with cirrhosis. Nippon Geka Gakkai Zasshi. 2004;105:669–673
  14. Llovet JM, Fuster J, Bruix J Barcelona-Clinic Liver Cancer Group. The Barcelona approach: diagnosis, staging, and treatment of hepatocellular carcinoma. Liver Transpl. 2004;10:S115–S120
  15. Chrusch C, Bands C, Bose D, Li X, Jacobs H, Duke K, et al. Impaired hepatic extraction and increased splanchnic production contribute to lactic acidosis in canine sepsis. Am J Respir Crit Care Med. 2000;161:517–526
  16. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–213
  17. Fuster J, Garcia-Valdecasas JC, Grande L, Tabet J, Bruix J, Anglada T, et al. Hepatocellular carcinoma and cirrhosis. Results of surgical treatment in a European series. Ann Surg. 1996;223:297–302
  18. Asiyanbola B, Chang D, Gleisner AL, Nathan H, Choti MA, Schulick RD, et al. Operative mortality after hepatic resection: are literature-based rates broadly applicable?. J Gastrointest Surg. 2008;12:842–851
  19. Ozdogan M, Ersoy E, Dundar K, Albayrak L, Devay S, Gundogdu H. Beneficial effect of hyperbaric oxygenation on liver regeneration in cirrhosis. J Surg Res. 2005;129:260–264
  20. Suehiro T, Shimura T, Okamura K, Okada T, Okada K, Hashimoto S, et al. The effect of hyperbaric oxygen treatment on postoperative morbidity of left lobe donor in living donor adult liver transplantation. Hepatogastroenterology. 2008;55:1014–1019
  21. Shimizu Y, Miyazaki M, Shimizu H, Ito H, Nakagawa K, Ambiru S, et al. Beneficial effects of arterialization of the portal vein on extended hepatectomy. Br J Surg. 2000;87:784–789
  22. Asahi K, Nonami T. Experimental study of hepatic hemodynamics and hepatic oxygen consumption after hepatectomy. Nippon Geka Gakkai Zasshi. 1989;90:228–242
  23. Aoki T, Imamura H, Kaneko J, Sakamoto Y, Matsuyama Y, Kokudo N, et al. Intraoperative direct measurement of hepatic arterial buffer response in patients with or without cirrhosis. Liver Transpl. 2005;11:684–691
  24. Lautt WW. The 1995 Ciba-Geigy Award Lecture. Intrinsic regulation of hepatic blood flow. Can J Physiol Pharmacol. 1996;74:223–233
  25. Ayuse T, Brienza N, Revelly JP, O’Donnell CP, Boitnott JK, Robotham JL. Alternations in liver hemodynamics in an intact porcine model of endotoxin shock. Am J Physiol. 1995;268:H1106–H1114
  26. Gottmann U, Brinkkoetter PT, Bechtler M, Hoeger S, Karle C, Schaub M, et al. Effect of pre-treatment with catecholamines on cold preservation and ischemia/reperfusion-injury in rats. Kidney Int. 2006;70:321–328
  27. Rensing H, Bauer I, Kubulus D, Wolf B, Winning J, Ziegeler S, et al. Heme oxygenase-1 gene expression in pericentral hepatocytes through beta1-adrenoceptor stimulation. Shock. 2004;21:376–387
  28. Bauer M, Huse K, Settmacher U, Claus RA. The heme oxygenase-carbon monoxide system: regulation and role in stress response and organ failure. Intensive Care Med. 2008;34:640–648
  29. Raddatz A, Kubulus D, Winning J, Bauer I, Pradarutti S, Wolf B, et al. Dobutamine improves liver function after hemorrhagic shock through induction of heme oxygenase-1. Am J Respir Crit Care Med. 2006;174:198–207
  30. Rensing H, Bauer I, Zhang JX, Paxian M, Pannen BH, Yokoyama Y, et al. Endothelin-1 and heme oxygenase-1 as modulators of sinusoidal tone in the stress-exposed rat liver. Hepatology. 2002;36:1453–1465
  31. Garcia-Valdecasas JC, Fuster J, Charco R, Bombuy E, Fondevila C, Ferrer J, et al. Changes in portal vein flow after adult living-donor liver transplantation: does it influence postoperative liver function?. Liver Transpl. 2003;9:564–569
  32. Yagi S, Iida T, Hori T, Taniguchi K, Yamamoto C, Yamagiwa K, et al. Optimal portal venous circulation for liver graft function after living-donor liver transplantation. Transplantation. 2006;81:373–378

PII: S0168-8278(09)00809-5

doi: 10.1016/j.jhep.2009.12.008

Journal of Hepatology
Volume 52, Issue 3 , Pages 340-347 , March 2010

Article Tools

* Image Usage & Resolution