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Volume 52, Issue 5 , Pages 745-758 , May 2010

Primary biliary cirrhosis: A 2010 update

Received 14 October 2009 ,Revised 27 November 2009 ,Accepted 30 November 2009.

PBC results from a combination of multiple genetic and environmental factors that may affect the immune system and the liver.

PBC results from a combination of multiple genetic and environmental factors that may affect the immune system and the liver.
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PBC sequential events: from PDCE2-breakdown tolerance to cirrhosis and liver failure.

PBC sequential events: from PDCE2-breakdown tolerance to cirrhosis and liver failure.
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(A) Typical aspect of the lymphocytic interface hepatitis in PBC; (B) biliary piecemeal necrosis with marked increase of ductular profiles accompanied by oedema, neutrophils, and fibroplasia.

(A) Typical aspect of the lymphocytic interface hepatitis in PBC; (B) biliary piecemeal necrosis with marked increase of ductular profiles accompanied by oedema, neutrophils, and fibroplasia.
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Schematic representation of the putative sequence events in the fibrogenesis process of PBC (ET1: endothelin 1, PDGF: platelet-derived growth factor, VEGF: vascular epithelial growth factor, CCL2: che

Schematic representation of the putative sequence events in the fibrogenesis process of PBC (ET1: endothelin 1, PDGF: platelet-derived growth factor, VEGF: vascular epithelial growth factor, CCL2: chemokine ligand 2, TGFβ: transforming growth factor β, NGF: nerve growth factor, BMD: bone marrow derived-cells, EMT: epithelial–mesenchymal transition).
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Patterns of development of ductopenia and fibrosis in the three major clinical forms of PBC.

Patterns of development of ductopenia and fibrosis in the three major clinical forms of PBC.
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