Journal of Hepatology
Volume 52, Issue 5 , Pages 698-704 , May 2010

The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

  • Satoshi Shimizu

      Affiliations

    • Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
    • These authors contributed equally to this work and share first authorship.
    • ,
  • Tetsuo Takehara

      Affiliations

    • Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
    • These authors contributed equally to this work and share first authorship.
    • ,
  • Hayato Hikita

      Affiliations

    • Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
    • ,
  • Takahiro Kodama

      Affiliations

    • Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
    • ,
  • Takuya Miyagi

      Affiliations

    • Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
    • ,
  • Atsushi Hosui

      Affiliations

    • Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
    • ,
  • Tomohide Tatsumi

      Affiliations

    • Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
    • ,
  • Hisashi Ishida

      Affiliations

    • Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
    • ,
  • Takehiro Noda

      Affiliations

    • Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Hiroaki Nagano

      Affiliations

    • Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Yuichiro Doki

      Affiliations

    • Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Masaki Mori

      Affiliations

    • Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Norio Hayashi

      Affiliations

    • Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 6 6879 3621; fax: +81 6 6879 3629.

Received 2 July 2009 ,Revised 17 November 2009 ,Accepted 2 December 2009.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.

PII: S0168-8278(10)00082-6

doi: 10.1016/j.jhep.2009.12.024

Journal of Hepatology
Volume 52, Issue 5 , Pages 698-704 , May 2010

Article Tools

* Image Usage & Resolution