Journal of Hepatology
Volume 52, Issue 5 , Pages 690-697 , May 2010

Let-7g targets collagen type I α2 and inhibits cell migration in hepatocellular carcinoma

  • Junfang Ji

      Affiliations

    • Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Centre for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    • These authors contributed equally to this work.
    • ,
  • Lei Zhao

      Affiliations

    • Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Centre for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    • Shandong Provincial Tumour Hospital and Institute of Oncology, Jinan, China
    • These authors contributed equally to this work.
    • ,
  • Anuradha Budhu

      Affiliations

    • Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Centre for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    • ,
  • Marshonna Forgues

      Affiliations

    • Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Centre for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    • ,
  • Hu-Liang Jia

      Affiliations

    • Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China
    • ,
  • Lun-Xiu Qin

      Affiliations

    • Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China
    • ,
  • Qing-Hai Ye

      Affiliations

    • Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China
    • ,
  • Jinming Yu

      Affiliations

    • Shandong Provincial Tumour Hospital and Institute of Oncology, Jinan, China
    • ,
  • Xuetao Shi

      Affiliations

    • Shandong Provincial Tumour Hospital and Institute of Oncology, Jinan, China
    • ,
  • Zhao-You Tang

      Affiliations

    • Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China
    • ,
  • Xin Wei Wang

      Affiliations

    • Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Centre for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    • Corresponding Author InformationCorresponding author. Address: 37 Convent Dr., MSC 4258, Building 37, Room 3044A, Bethesda, MD 20892, USA. Tel.: +1 301 496 2099; fax: +1 301 496 0497.

Received 9 July 2009 ,Revised 3 December 2009 ,Accepted 12 December 2009.

References 

  1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108
  2. El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999;340:745–750
  3. Budhu A, Wang XW. Human hepatocellular carcinoma: new insights from gene expression profiling. In:  Jeffreis LP editors. New developments in cancer research. Nova Science Publishers Inc.; 2006;p. 1–32
  4. Ye QH, Qin LX, Forgues M, He P, Kim JW, Peng AC, et al. Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med. 2003;9:416–423
  5. Budhu A, Jia HL, Forgues M, Liu CG, Goldstein D, Lam A, et al. Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology. 2008;47:897–907
  6. Ji J, Wang XW. New kids on the block: diagnostic and prognostic microRNAs in hepatocellular carcinoma. Cancer Biol Ther. 2009;8
  7. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75:843–854
  8. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000;403:901–906
  9. Roush S, Slack FJ. The let-7 family of microRNAs. Trends Cell Biol. 2008;18:505–516
  10. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, et al. RAS is regulated by the let-7 microRNA family. Cell. 2005;120:635–647
  11. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 2004;64:3753–3756
  12. Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, et al. Let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007;131:1109–1123
  13. Esquela-Kerscher A, Trang P, Wiggins JF, Patrawala L, Cheng A, Ford L, et al. The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle. 2008;7:759–764
  14. Chang SS, Jiang WW, Smith I, Poeta LM, Begum S, Glazer C, et al. MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer. 2008;123:2791–2797
  15. Torrisani J, Bournet B, du Chalret RM, Bouisson M, Souque A, Escourrou J, et al. Let-7 microRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression. Hum Gene Ther. 2009;20:831–844
  16. Peng Y, Laser J, Shi G, Mittal K, Melamed J, Lee P, et al. Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma. Mol Cancer Res. 2008;6:663–673
  17. Schultz J, Lorenz P, Gross G, Ibrahim S, Kunz M. MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. Cell Res. 2008;18:549–557
  18. Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet. 2007;39:673–677
  19. Lee YS, Dutta A. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev. 2007;21:1025–1030
  20. Mayr C, Hemann MT, Bartel DP. Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science. 2007;315:1576–1579
  21. Guo Y, Chen Y, Ito H, Watanabe A, Ge X, Kodama T, et al. Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. Gene. 2006;384:51–61
  22. Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, et al. Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet. 2009;41:843–848
  23. Heo I, Joo C, Cho J, Ha M, Han J, Kim VN. Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell. 2008;32:276–284
  24. Ji J, Yamashita T, Budhu A, Forgues M, Jia HL, Li C, et al. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology. 2009;50:472–480
  25. Gupta GP, Massague J. Cancer metastasis: building a framework. Cell. 2006;127:679–695
  26. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell. 2003;115:787–798
  27. Shintani Y, Hollingsworth MA, Wheelock MJ, Johnson KR. Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. Cancer Res. 2006;66:11745–11753
  28. Tanjore H, Kalluri R. The role of type IV collagen and basement membranes in cancer progression and metastasis. Am J Pathol. 2006;168:715–717
  29. Ogawa M, Ikeuchi K, Watanabe M, Etoh K, Kobayashi T, Takao Y, et al. Expression of matrix metalloproteinase 7, laminin and type IV collagen-associated liver metastasis in human colorectal cancer: immunohistochemical approach. Hepatogastroenterology. 2005;52:875–880
  30. Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA, et al. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci USA. 2008;105:3903–3908
  31. Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, et al. A SNP in a let-7 microRNA complementary site in the KRAS 3′ untranslated region increases non-small cell lung cancer risk. Cancer Res. 2008;68:8535–8540
  32. Christensen BC, Moyer BJ, Avissar M, Ouellet LG, Plaza S, McClean MD, et al. A let-7 microRNA binding site polymorphism in the KRAS 3′ UTR is associated with reduced survival in oral cancers. Carcinogenesis. 2009;30:1003–1007
  33. Lettre G, Jackson AU, Gieger C, Schumacher FR, Berndt SI, Sanna S, et al. Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet. 2008;40:584–591
  34. Nishino J, Kim I, Chada K, Morrison SJ. Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf expression. Cell. 2008;135:227–239
  35. Yamashita T, Forgues M, Wang W, Kim JW, Ye Q, Jia H, et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res. 2008;68:1451–1461
  36. Yamashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY, et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology. 2009;136:1012–1024
  37. Kota J, Chivukula RR, O’donnell KA, Wentzel EA, Montgomery CL, Hwang HW, et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell. 2009;137:1005–1017

PII: S0168-8278(10)00084-X

doi: 10.1016/j.jhep.2009.12.025

Journal of Hepatology
Volume 52, Issue 5 , Pages 690-697 , May 2010

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