Journal of Hepatology
Volume 52, Issue 5 , Pages 665-671 , May 2010

Use of desirability functions to evaluate health status in patients with cirrhosis

  • Chris Gennings

      Affiliations

    • Department of Biostatistics, Virginia Commonwealth University, Theatre Row, Rm 3026, 730 East Broad Street, Richmond, VA 23298-0032, USA
    • Solveritas, LLC, Richmond, VA, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 804 827 2058; fax: +1 804 828 8900.
    • ,
  • Douglas Heuman

      Affiliations

    • McGuire VA Medical Center, Richmond, VA, USA
    • Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    • ,
  • Otis Fulton

      Affiliations

    • Metametrics, Durham, NC, USA
    • ,
  • Arun J. Sanyal

      Affiliations

    • Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA

Received 19 July 2009 ,Revised 5 November 2009 ,Accepted 2 December 2009.

References 

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  3. Derringer G. A balancing act: optimizing a product’s properties. Qual Prog. 1994;27:51–58
  4. Gibb RD Virginia Commonwealth University. Optimal treatment combination estimation for univariate and multivariate response surface applications. Virginia Commonwealth University; 1998;p. XI [289 leaves]
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  6. Coffey T, Gennings C, Moser VC. The simultaneous analysis of discrete and continuous outcomes in a dose–response study: using desirability functions. Regul Toxicol Pharmacol. 2007;48:51–58
  7. Shih M, Gennings C, Chinchilli VM, Carter WH. Titrating and evaluating multi-drug regimens within subjects. Stat Med. 2003;22:2257–2279
  8. Sanyal AJ, Gennings C, Reddy KR, Wong F, Kowdley KW, Benner K, et al. The North American study for the treatment of refractory ascites. Gastroenterology. 2003;124:634–641
  9. Andrich D. Rasch models for measurement. Sage University papers series. Quantitative applications in the social sciences. Newbury Park: Sage Publications; 1988.
  10. Horne BD, May HT, Muhlestein JB, Ronnow BS, Lappé DL, Renlund DG, et al. Exceptional mortality prediction by risk scores from common laboratory tests. Am J Med. 2009;122:550–558
  11. May HT, Horne BD, Ronnow BS, Renlund DG, Muhlestein JB, Lappé DL, et al. Superior predictive ability for death of a basic metabolic profile risk score. Am Heart J. 2009;157:946–954
  12. UNOS. United Network of Organ Sharing: Resources, Meld/Peld Calculator, <http://www.unos.org/resources/meldpeldcalculator.asp> [accessed 06.19.2009].

PII: S0168-8278(10)00085-1

doi: 10.1016/j.jhep.2009.12.026

Journal of Hepatology
Volume 52, Issue 5 , Pages 665-671 , May 2010

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