Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

Rector, R. Scott; Thyfault, John P.; Uptergrove, Grace M.; Morris, E. Matthew; Naples, Scott P.; Borengasser, Sarah J.; Mikus, Catherine R.; Laye, Matthew J.; Laughlin, M. Harold; Booth, Frank W.; Ibdah, Jamal A.

doi:10.1016/j.jhep.2009.11.030

« Previous Next »Journal of Hepatology
Volume 52, Issue 5 , Pages 727-736, May 2010

Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

R. Scott Rector
- Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support & Education Building, University of Missouri-Columbia, Columbia, MO 65212, USA
John P. Thyfault
- Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support & Education Building, University of Missouri-Columbia, Columbia, MO 65212, USA
- Harry S. Truman Memorial Veterans Medical Center, Columbia, MO, USA
- Departments of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
Grace M. Uptergrove
- Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support & Education Building, University of Missouri-Columbia, Columbia, MO 65212, USA
E. Matthew Morris
- Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support & Education Building, University of Missouri-Columbia, Columbia, MO 65212, USA
- Departments of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
Scott P. Naples
- Departments of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
Sarah J. Borengasser
- Departments of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
Catherine R. Mikus
- Departments of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
Matthew J. Laye
- Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA
M. Harold Laughlin
- Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA
- Biomedical Sciences, University of Missouri, Columbia, MO, USA
- Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA
Frank W. Booth
- Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA
- Biomedical Sciences, University of Missouri, Columbia, MO, USA
- Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA
Jamal A. Ibdah
- Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support & Education Building, University of Missouri-Columbia, Columbia, MO 65212, USA
- Harry S. Truman Memorial Veterans Medical Center, Columbia, MO, USA
- Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA
- Corresponding author. Address: Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support & Education Building, University of Missouri-Columbia, Columbia, MO 65212, USA. Tel.: +1 573 882 0482; fax: +1 573 884 4595.