Journal of Hepatology
Volume 52, Issue 5 , Pages 727-736 , May 2010

Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

  • R. Scott Rector

      Affiliations

    • Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support & Education Building, University of Missouri-Columbia, Columbia, MO 65212, USA
    • ,
  • John P. Thyfault

      Affiliations

    • Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support & Education Building, University of Missouri-Columbia, Columbia, MO 65212, USA
    • Harry S. Truman Memorial Veterans Medical Center, Columbia, MO, USA
    • Departments of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
    • ,
  • Grace M. Uptergrove

      Affiliations

    • Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support & Education Building, University of Missouri-Columbia, Columbia, MO 65212, USA
    • ,
  • E. Matthew Morris

      Affiliations

    • Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support & Education Building, University of Missouri-Columbia, Columbia, MO 65212, USA
    • Departments of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
    • ,
  • Scott P. Naples

      Affiliations

    • Departments of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
    • ,
  • Sarah J. Borengasser

      Affiliations

    • Departments of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
    • ,
  • Catherine R. Mikus

      Affiliations

    • Departments of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
    • ,
  • Matthew J. Laye

      Affiliations

    • Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA
    • ,
  • M. Harold Laughlin

      Affiliations

    • Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA
    • Biomedical Sciences, University of Missouri, Columbia, MO, USA
    • Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA
    • ,
  • Frank W. Booth

      Affiliations

    • Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA
    • Biomedical Sciences, University of Missouri, Columbia, MO, USA
    • Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA
    • ,
  • Jamal A. Ibdah

      Affiliations

    • Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support & Education Building, University of Missouri-Columbia, Columbia, MO 65212, USA
    • Harry S. Truman Memorial Veterans Medical Center, Columbia, MO, USA
    • Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA
    • Corresponding Author InformationCorresponding author. Address: Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support & Education Building, University of Missouri-Columbia, Columbia, MO 65212, USA. Tel.: +1 573 882 0482; fax: +1 573 884 4595.

Received 25 August 2009 ,Revised 20 October 2009 ,Accepted 5 November 2009.

References 

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PII: S0168-8278(10)00091-7

doi: 10.1016/j.jhep.2009.11.030

Journal of Hepatology
Volume 52, Issue 5 , Pages 727-736 , May 2010

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