« Previous
Next »
Journal of Hepatology
Volume 53, Issue 2
, Pages 318-325
, August 2010
Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis
References
- Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events. Am J Physiol. 1999;276:G1260–1272
- . Cell polyploidy: its relation to tissue growth and function. Int Rev Cytol. 1977;50:275–332
- A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 1995;92:9363–9367
- . Cellular senescence in cancer and aging. Cell. 2007;130:223–233
- Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell. 2008;133:1006–1018
- Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell. 2008;133:1019–1031
- . Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell. 2008;132:363–374
- . Microarray analysis of replicative senescence. Curr Biol. 1999;9:939–945
- Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008;6:2853–2868
- Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology. 2007;132:415–431
- Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells. Hepatology. 2008;47:958–965
- Monocyte chemotactic protein-1, -2, and -3 are distinctively expressed in portal tracts and granulomata in primary biliary cirrhosis: implications for pathogenesis. J Pathol. 2001;193:102–109
- Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts. Hepatology. 2005;41:506–516
- . Identification and specificity of a cDNA encoding the 70
kDa mitochondrial antigen recognized in primary biliary cirrhosis. J Immunol. 1987;138:3525–3531 - . Primary biliary cirrhosis. New Engl J Med. 1996;335:1570–1580
- . Diseases of the bile ducts. In: MacSween R, Burt A, BC P, Ishak K, Scheuer P, Anthony P editor. Pathology of the liver. 4th ed.. London: Churchill Livingstone; 2001;p. 435–506
- . Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis. Gastroenterology. 1979;76:1326–1332
- . Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis. Proc Natl Acad Sci USA. 1988;85:8654–8658
- Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis. J Clin Invest. 2002;109:1231–1240
- Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis. J Clin Invest. 1998;102:1831–1840
- . Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence. Hepatology. 2008;48:186–195
- . Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss. J Pathol. 2005;205:451–459
- . Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21(WAF1/Cip1) in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: An immunohistochemical study. J Autoimmun. 2008;31:73–78
- . Decreased expression of Bmi-1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis. Am J Pathol. 2006;169:831–845
- Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs. Am J Pathol. 2001;158:1379–1390
- Senescence of activated stellate cells limits liver fibrosis. Cell. 2008;134:657–667
- Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. Hum Pathol. 2001;32:327–332
- Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. Faseb J. 2002;16:935–942
- Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis. Hepatology. 2007;45:968–976
- Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma. Hepatology. 2005;42:522–526
- . Increased expression of interleukin-6 and tumor necrosis factor-alpha in pathologic biliary epithelial cells: in situ and culture study. Lab Invest. 1998;78:89–100
- Lipopolysaccharide induces overexpression of MUC2 and MUC5AC in cultured biliary epithelial cells: possible key phenomenon of hepatolithiasis. Am J Pathol. 2002;161:1475–1484
- . Expression of blood-group-related antigens in the intrahepatic biliary tree and hepatocytes in normal livers and various hepatobiliary diseases. Hepatology. 1989;10:174–178
- . Small-duct primary sclerosing cholangitis. Semin Liver Dis. 1991;11:11–17
- . Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology. 1994;19:1513–1520
- Alterations in tight junctions differ between primary biliary cirrhosis and primary sclerosing cholangitis. Hepatology. 2001;33:1460–1468
- Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 2007;445:656–660
- . Putting the stress on senescence. Curr Opin Cell Biol. 2001;13:748–753
- . Immunopathology of the human biliary tree. In: Sirica A, Longnecker D editor. Biliary and pancreatic ductal epithelia. New York: Marcel Dekker Inc.; 1997;p. 127–180
PII: S0168-8278(10)00324-7
doi: 10.1016/j.jhep.2010.03.008
© 2010 European Association for the Study of the Liver. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of Hepatology
Volume 53, Issue 2
, Pages 318-325
, August 2010
