Journal of Hepatology
Volume 53, Issue 2 , Pages 388-389 , August 2010

Getting closer to the patient: Upgrade of hepatitis C virus infection in primary human hepatocytes

  • Mirjam B. Zeisel

      Affiliations

    • Inserm, U748, Strasbourg, France
    • Université de Strasbourg, Strasbourg, France
    • Corresponding Author InformationCorresponding author. Address: Inserm U748, Institute of Virology, 3 rue Koeberlé, 67000 Strasbourg, France. Tel.: +33 3 68 85 37 03; fax: +33 3 68 85 37 24.
    • ,
  • Marine Turek

      Affiliations

    • Inserm, U748, Strasbourg, France
    • Université de Strasbourg, Strasbourg, France
    • ,
  • Thomas F. Baumert

      Affiliations

    • Inserm, U748, Strasbourg, France
    • Université de Strasbourg, Strasbourg, France
    • Pôle Hépato-digestif, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
    • Corresponding Author InformationCorresponding author. Address: Inserm U748, Institute of Virology, 3 rue Koeberlé, 67000 Strasbourg, France. Tel.: +33 3 68 85 37 03; fax: +33 3 68 85 37 24.

Received 6 April 2010 ,Revised 7 April 2010 ,Accepted 7 April 2010.

References 

  1. Wakita T, Pietschmann T, Kato T, Date T, Miyamoto M, Zhao Z, et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med. 2005;11:791–796
  2. Wang L, Boyer JL. The maintenance and generation of membrane polarity in hepatocytes. Hepatology. 2004;39:892–899
  3. Mercer DF, Schiller DE, Elliott JF, Douglas DN, Hao C, Rinfret A, et al. Hepatitis C virus replication in mice with chimeric human livers. Nat Med. 2001;7:927–933
  4. Bissig KD, Wieland SF, Tran P, Isogawa M, Le TT, Chisari FV, et al. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest. 2010;120:924–930
  5. Khetani SR, Bhatia SN. Microscale culture of human liver cells for drug development. Nat Biotech. 2008;26:120–126
  6. Jones CT, Catanese MT, Law LM, Khetani SR, Syder AJ, Ploss A, et al. Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system. Nat Biotech. 2010;28:167–171
  7. Ploss A, Khetani SR, Jones CT, Syder AJ, Trehan K, Gaysinskaya VA, et al. Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. Proc Natl Acad Sci USA. 2010;107:3141–3145
  8. Reynolds GM, Harris HJ, Jennings A, Hu K, Grove J, Lalor PF, et al. Hepatitis C virus receptor expression in normal and diseased liver tissue. Hepatology. 2008;47:418–427
  9. Popescu CI, Dubuisson J. Role of lipid metabolism in hepatitis C virus assembly and entry. Biol Cell. 2009;102:63–74
  10. Zeisel MB, Cosset FL, Baumert TF. Host neutralizing responses and pathogenesis of hepatitis C virus infection. Hepatology. 2008;48:299–307

PII: S0168-8278(10)00384-3

doi: 10.1016/j.jhep.2010.04.004

Journal of Hepatology
Volume 53, Issue 2 , Pages 388-389 , August 2010

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