Journal of Hepatology
Volume 53, Issue 2 , Pages 392-393 , August 2010

The use of corticosteroids in severe alcohol hepatitis: We need to look beyond this controversy

Received 13 March 2010 ,Revised 23 March 2010 ,Accepted 24 March 2010.

References 

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  2. Dunn W, Jamil LH, Brown LS, Wiesner RH, Kim WR, Menon KVN, et al. MELD accurately predicts mortality in patients with alcoholic hepatitis. Hepatology. 2005;41:353–358
  3. Srikureja W, Kyulo NL, Runyon BA, Hu KQ. Meld is a better prognostic model than Child–Turcotte–Pugh score or discriminant function score in patients with alcoholic hepatitis. J Hepatol. 2005;42:700–706
  4. Carithers RL, Herlong HF, Diehl AM, Shaw EW, Combes B, Fallon HJ, et al. Methylprednisolone therapy in patients with severe alcoholic hepatitis: a randomized multicenter trial. Ann Intern Med. 1989;110:685–690
  5. Phillips M, Curtis H, Portmann B, Donaldson N, Bomford A, O’Grady J. Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis – a randomised clinical trial. J Hepatol. 2006;44:784–790
  6. Mathurin P, Mendenhall C, Carithers RL, Ramond MJ, Maddrey WC, Garstide P, et al. Corticosteroids improve short term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials. J Hepatol. 2002;36:480–487
  7. Bories P, Guedj JY, Mirouze D, Yousfi A, Michel H. Traitement de l’hépatite alcoolique aiguë par la prednisolone. Presse Med. 1987;16:769–772
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  10. Louvet A, Naveau S, Abdelnour M, Ramond MJ, Diaz E, Fartoux L, et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology. 2007;45:1348–1354
  11. Mathurin P, O’Grady J, Carithers RL, Phillips M, Ramond MJ, Louvet A, et al. Corticosteroids improve 28-day survival in patients with severe alcoholic hepatitis: individual data analysis of the last 5 randomized controlled trials. Hepatology. 2008;48:170A
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PII: S0168-8278(10)00385-5

doi: 10.1016/j.jhep.2010.03.014

Journal of Hepatology
Volume 53, Issue 2 , Pages 392-393 , August 2010

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