Journal of Hepatology
Volume 53, Issue 4 , Pages 655-662 , October 2010

Early growth response-1 attenuates liver injury and promotes hepatoprotection after carbon tetrachloride exposure in mice

  • Michele T. Pritchard

      Affiliations

    • Departments of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA
    • Corresponding Author InformationCorresponding author. Address: Department of Pathobiology, NE40 Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Tel.: +1 216 444 8613; fax: +1 216 636 1493.
    • ,
  • Jessica I. Cohen

      Affiliations

    • Departments of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA
    • Department of Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA
    • ,
  • Sanjoy Roychowdhury

      Affiliations

    • Departments of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA
    • ,
  • Brian T. Pratt

      Affiliations

    • Departments of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA
    • ,
  • Laura E. Nagy

      Affiliations

    • Departments of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA
    • Departments of Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    • Department of Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA

Received 5 October 2009 ,Revised 23 April 2010 ,Accepted 26 April 2010.

References 

  1. Bhave VS, Donthamsetty S, Latendresse JR, Mehendale HM. Inhibition of cyclooxygenase-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury. Toxicol Appl Pharmacol. 2008;228:239–246
  2. Bhave VS, Donthamsetty S, Latendresse JR, Muskhelishvili L, Mehendale HM. Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient cyclooxygenase-2. Toxicol Appl Pharmacol. 2008;228:225–238
  3. Chaisson ML, Brooling JT, Ladiges W, Tsai S, Fausto N. Hepatocyte-specific inhibition of NF-κB leads to apoptosis after TNF treatment, but not after partial hepatectomy. J Clin Invest. 2002;110:193–202
  4. Diez-Fernandez C, Sanz N, Bosca L, Hortelano S, Cascales M. Involvement of nitric oxide synthesis in hepatic perturbations induced in rats by a necrogenic dose of thioacetamide. Br J Pharmacol. 1997;121:820–826
  5. Fausto N, Campbell JS, Riehle KJ. Liver regeneration. Hepatology. 2006;43:S45–S532
  6. FitzGerald MJ, Webber EM, Donovan JR, Fausto N. Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration. Cell Growth Differ. 1995;6:417–427
  7. Gao B. Therapeutic potential of interleukin-6 in preventing obesity- and alcohol-associated fatty liver transplant failure. Alcohol (Fayetteville, NY). 2004;34:59–65
  8. Gashler A, Sukhatme VP. Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog Nucleic Acid Res Mol Biol. 1995;50:191–224
  9. Gomez-Lechon MJ. Oncostatin M: signal transduction and biological activity. Life Sci. 1999;65:2019–2030
  10. Hamada T, Sato A, Hirano T, Yamamoto T, Son G, Onodera M, et al. Oncostatin M gene therapy attenuates liver damage induced by dimethylnitrosamine in rats. Am J Pathol. 2007;171:872–881
  11. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J. 2003;374:1–20
  12. Isoda K, Koide H, Kojima M, Arita E, Ikkaku M, Higashiyama S, et al. Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBPbeta gene. Biochem Biophys Res Commun. 2005;329:182–187
  13. Kodavanti PR, Joshi UM, Young RA, Meydrech EF, Mehendale HM. Protection of hepatotoxic and lethal effects of CCl4 by partial hepatectomy. Toxicol Pathol. 1989;17:494–505
  14. Lee SL, Sadovsky Y, Swirnoff AH, Polish JA, Goda P, Gavrilina G, et al. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science. 1996;273:1219–1221
  15. Ma Y, Streiff RJ, Liu J, Spence MJ, Vestal RE. Cloning and characterization of human oncostatin M promoter. Nucleic acids Res. 1999;27:4649–4657
  16. Mangipudy RS, Rao PS, Mehendale HM. Effect of an antimitotic agent colchicine on thioacetamide hepatotoxicity. Environ Health Perspect. 1996;104:744–749
  17. McMullen MR, Pritchard MT, Wang Q, Millward CA, Croniger CM, Nagy LE. Early growth response-1 transcription factor is essential for ethanol-induced fatty liver injury in mice. Gastroenterology. 2005;128:2066–2076
  18. Mehendale HM. Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol Pathol. 2005;33:41–51
  19. Morio LA, Chiu H, Sprowles KA, Zhou P, Heck DE, Gordon MK, et al. Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute liver injury induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol. 2001;172:44–51
  20. Nakamura K, Nonaka H, Saito H, Tanaka M, Miyajima A. Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice. Hepatology. 2004;39:635–644
  21. Pritchard MT, Nagy LE. Ethanol-induced liver injury: potential roles for egr-1. Alcohol Clin Exp Res. 2005;29:146S–150S
  22. Pritchard MT, Roychowdhury S, McMullen MR, Guo L, Arteel GE, Nagy LE. Early growth response-1 contributes to galactosamine/lipopolysaccharide-induced acute liver injury in mice. Am J Physiol Gastrointest Liver Physiol. 2007;293:G1124–G1133
  23. Quiroga J, Prieto J. Liver cytoprotection by prostaglandins. Pharmacol Ther. 1993;58:67–91
  24. Rai RM, Lee FY, Rosen A, Yang SQ, Lin HZ, Koteish A, et al. Impaired liver regeneration in inducible nitric oxide synthase deficient mice. Proc Natl Acad Sci USA. 1998;95:13829–13834
  25. Salkowski CA, Detore G, McNally R, van Rooijen N, Vogel SN. Regulation of inducible nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccharide in vivo: the roles of macrophages, endogenous IFN-gamma, and TNF receptor-1-mediated signaling. J Immunol. 1997;158:905–912
  26. Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem. 2000;69:145–182
  27. Streetz KL, Tacke F, Leifeld L, Wustefeld T, Graw A, Klein C, et al. Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases. Hepatology. 2003;38:218–229
  28. Taub R. Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol. 2004;5:836–847
  29. Taub R, Greenbaum LE, Peng Y. Transcriptional regulatory signals define cytokine-dependent and -independent pathways in liver regeneration. Semin Liver Dis. 1999;19:117–127
  30. Taylor BS, Alarcon LH, Billiar TR. Inducible nitric oxide synthase in the liver: regulation and function. Biochemistry (Mosc). 1998;63:766–781
  31. Teoh NC, Farrell GC. Hepatic ischemia reperfusion injury: pathogenic mechanisms and basis for hepatoprotection. J Gastroenterol Hepatol. 2003;18:891–902
  32. Vila-del Sol V, Fresno M. Involvement of TNF and NF-kappa B in the transcriptional control of cyclooxygenase-2 expression by IFN-gamma in macrophages. J Immunol. 2005;174:2825–2833
  33. Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol. 2003;33:105–136
  34. Yao J, Mackman N, Edgington TS, Fan ST. Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors. J Biol Chem. 1997;272:17795–17801
  35. Zeini M, Hortelano S, Traves PG, Martin-Sanz P, Bosca L. Simultaneous abrogation of NOS-2 and COX-2 activities is lethal in partially hepatectomised mice. J Hepatol. 2004;40:926–933

PII: S0168-8278(10)00526-X

doi: 10.1016/j.jhep.2010.04.017

Journal of Hepatology
Volume 53, Issue 4 , Pages 655-662 , October 2010

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