Journal of Hepatology
Volume 53, Issue 4 , Pages 624-629 , October 2010

Measurement of hepatic vein pressure gradient in children with chronic liver diseases

  • Roberto Miraglia

      Affiliations

    • Department of Diagnostic and Interventional Radiology, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), University of Pittsburgh Medical Center, Palermo, Italy
    • Corresponding Author InformationCorresponding author. Address: Department of Diagnostic and Interventional Radiology, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Via Tricomi 1, 90127 Palermo, Italy. Tel.: +39 3357000350; fax: +39 091 2192344.
    • ,
  • Angelo Luca

      Affiliations

    • Department of Diagnostic and Interventional Radiology, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), University of Pittsburgh Medical Center, Palermo, Italy
    • ,
  • Luigi Maruzzelli

      Affiliations

    • Department of Diagnostic and Interventional Radiology, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), University of Pittsburgh Medical Center, Palermo, Italy
    • ,
  • Marco Spada

      Affiliations

    • Department Transplantation Surgery, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), University of Pittsburgh Medical Center, Palermo, Italy
    • ,
  • Silvia Riva

      Affiliations

    • Department of Pediatric Hepatology, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), University of Pittsburgh Medical Center, Palermo, Italy
    • ,
  • Settimo Caruso

      Affiliations

    • Department of Diagnostic and Interventional Radiology, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), University of Pittsburgh Medical Center, Palermo, Italy
    • ,
  • Giuseppe Maggiore

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Pediatrics, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    • ,
  • Bruno Gridelli

      Affiliations

    • Department Transplantation Surgery, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), University of Pittsburgh Medical Center, Palermo, Italy
    • ,
  • Jaime Bosch

      Affiliations

    • Liver Unit, Hospital Clinic I Provincial de Barcelona and Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD) Barcelona, Spain

Received 24 November 2009 ,Revised 22 April 2010 ,Accepted 22 April 2010.

References 

  1. De Franchis R. Evolving consensus in portal hypertension. Report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2005;43:167–176
  2. Shneider B, Emre S, Groszmann R, Karani J, McKiernan P, Sarin S, et al. Expert pediatric opinion on the report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension. Pediatr Transplant. 2006;10:893–907
  3. Groszmann RJ, Wongcharatrawee S. The hepatic venous pressure gradient: anything worth doing should be done right. Hepatology. 2004;39:280–282
  4. D’Amico G, Garcia-Pagan JC, Luca A, Bosch J, Rodes J, Bosch J. Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: a systematic review. Gastroenterology. 2006;131:1611–1624
  5. Abraldes JG, Tarantino I, Turnes J, Garcia-Pagan JC, Rodes J, Bosch J. Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis. Hepatology. 2003;37:902–908
  6. Thalheimer U, Mela M, Patch D, Burroughs AK. Targeting portal pressure measurement: a critical reappraisal. Hepatology. 2004;39:286–290
  7. Feu F, Garcia-Pagan JC, Bosch J, Luca A, Teres J, Escorsell A, et al. Relation between portal pressure response to pharmacotherapy and risk of recurrent variceal hemorrhage in patients with cirrhosis. Lancet. 1995;346:1056–1059
  8. Villanueva C, Minana J, Ortiz J, Gallego A, Soriano G, Torrax X, et al. Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding. N Eng J Med. 2001;345:647–655
  9. Garcia-Tsao G, Groszman RJ, Fisher RL, Conn HO, Atterbury CE, Glickman M. Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology. 1985;5:419–424
  10. Goncalves ME, Cardoso SR, Maksoud JG. Prophilactic sclerotherapy in children with esophageal varices: long-term results of a controlled prospective randomized trial. J Pediatr Surg. 2000;35:401–405
  11. Keiding S, Vilstrup H. Intrahepatic heterogeneity of hepatic venous pressure gradient in human cirrhosis. Scand J Gastroenterol. 2002;37:960–964
  12. Zargar SA, Javid G, Khan BA, Yattoo GN, Shah AH, Gulzar GM, et al. Endoscopic ligation compared with sclerotherapy for bleeding esophageal varices in children with extrahepatic portal vein obstruction. Hepatology. 2002;36:666–672
  13. Shashidhar H, Langhans N, Grand RJ. Propanolol in prevention of portal hypertensive hemorrhage in children: a pilot study. J Pediatr Gastroenterol Nutr. 1999;29:12–17
  14. Ozsoylu S, Koçak N, Demir H, Yüce A, Gürakan F, Ozen H. Propranolol for primary and secondary prophylaxis of variceal bleeding in children with cirrhosis. Turk J Pediatr. 2000;42:31–33
  15. Erkan T, Cullu F, Kutlu T, Emir H, Yeşildağ E, Sarimurat N, et al. Management of portal hypertension in children: a retrospective study with long term follow up. Acta Gastroenterol Belg. 2003;66:213–217
  16. Schreiber , Richard A. Propranolol and portal hypertension: should kids be on the block?. J Pediatr Gastroenterol Nutr. 1999;29:10–11
  17. Ling SC. Should children with esophageal varices receive beta-blockers for the primary prevention of variceal hemorrhage?. Can J Gastroenterol. 2005;19:661–666
  18. Habdank K, Restrepo R, Ng V, Connolly BL, Temple MJ, Amaral J, et al. Combined sonographic and fluoroscopic guidance during transjugular hepatic biopsies performed in children: a retrospective study of 74 biopsies. Am J Roentgenol. 2003;180:1393–1398
  19. Johnson SP, Leyendecker JR, Joseph FB, Joseph AE, Diffin DC, Devoid D, et al. Transjugular portosystemic shunts in pediatric patients awaiting liver transplantation. Transplantation. 1996;62:1178–1181
  20. Steinlauf AF, Garcia-Tsao G, Zakko MF, Dicket K, Gupta T, Groszmann R. Low-dose midazolam sedation: an option for patients undergoing serial hepatic venous pressure measurement. Hepatology. 1999;29:1070–1073
  21. Bosch J, Abraldes JG, Berzigotti A, Garcia-Pagan JC. The clinical use of HVPG measurements in chronic liver disease. Nat Rev Gastroenterol Hepatol. 2009;6:537–582
  22. Garcia-Tsao G, Bosch J, Groszmann R. Portal hypertension and variceal bleeding unresolved issues. Summary of an American Association for the Study of Liver Diseases and European Association for the Study of the Liver single-topic conference. Hepatology. 2008;47:1764–1772
  23. La Mura V, Abraldes JG, Raffa S, Retto O, Berzigotti A, García-Pagán JC, et al. Prognostic value of acute hemodynamic response to i.v. propanolol in patients with cirrhosis and portal hypertension. J Hepatol. 2009;51:279–287
  24. Villanueva C, Aracil C, Colomo A, Hernández-Gea V, López-Balaguer JM, Alvarez-Urturi C, et al. Acute hemodynamic response to beta-blockers and prediction of long term outcome in primary prophylaxis of variceal bleeding. Gastroenterology. 2009;137:119–128
  25. Futagawa S, Fukazawa M, Musha H, Isomatsu T, Koyama K, Ito T, et al. Hepatic venography in noncirrotic portal hypertension. Radiology. 1981;141:303–309
  26. Okuda K. Non-cirrhotic portal hypertension versus idiopathic portal hypertension. J Gastroenterol Hepatol. 2002;17:S204–213
  27. Guelrud M, Beker S. Wedged hepatic venography. A comparative study of cirrhosis and hepatic schistostomiasis. Am J Gastroenterol. 1974;62:504–508
  28. Futagawa S, Fukazawa M, Horisawa M, Musha H, Ito T, Sugiura M, et al. Portographic liver changes in idiopathic noncirrhotic portal hypertension. AJR. 1980;134:917–923

PII: S0168-8278(10)00543-X

doi: 10.1016/j.jhep.2010.04.027

Journal of Hepatology
Volume 53, Issue 4 , Pages 624-629 , October 2010

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