Journal of Hepatology
Volume 53, Issue 4 , Pages 639-647 , October 2010

Cytokeratin 18-based modification of the MELD score improves prediction of spontaneous survival after acute liver injury

  • Lars P. Bechmann

      Affiliations

    • Dept. of Gastroenterology and Hepatology, University Hospital, 45122 Essen, Germany
    • ,
  • Christoph Jochum

      Affiliations

    • Dept. of Gastroenterology and Hepatology, University Hospital, 45122 Essen, Germany
    • ,
  • Peri Kocabayoglu

      Affiliations

    • Dept. of Gastroenterology and Hepatology, University Hospital, 45122 Essen, Germany
    • Dept. of General and Transplantation Surgery, University Hospital, 45122 Essen, Germany
    • ,
  • Jan-Peter Sowa

      Affiliations

    • Dept. of Gastroenterology and Hepatology, University Hospital, 45122 Essen, Germany
    • ,
  • Marco Kassalik

      Affiliations

    • Dept. of Gastroenterology and Hepatology, University Hospital, 45122 Essen, Germany
    • ,
  • Robert K. Gieseler

      Affiliations

    • Dept. of Gastroenterology and Hepatology, University Hospital, 45122 Essen, Germany
    • Div. of R&D, Rodos BioTarget GmbH, Medical Park Hannover, 30625 Hannover, Germany
    • ,
  • Fuat Saner

      Affiliations

    • Dept. of General and Transplantation Surgery, University Hospital, 45122 Essen, Germany
    • ,
  • Andreas Paul

      Affiliations

    • Dept. of General and Transplantation Surgery, University Hospital, 45122 Essen, Germany
    • ,
  • Christian Trautwein

      Affiliations

    • Dept. of Gastroenterology and Hepatology, University Hospital, Aachen, Germany
    • ,
  • Guido Gerken

      Affiliations

    • Dept. of Gastroenterology and Hepatology, University Hospital, 45122 Essen, Germany
    • ,
  • Ali Canbay

      Affiliations

    • Dept. of Gastroenterology and Hepatology, University Hospital, 45122 Essen, Germany
    • Corresponding Author InformationCorresponding author. Address: Dept. of Gastroenterology and Hepatology, University Hospital, Hufelandstr. 55, 45122 Essen, Germany. Tel.: +49 (201) 723 84713; fax: +49 (201) 723 5719.

References 

  1. O’Grady JG. Acute liver failure. Postgrad Med J. 2005;81:148–154
  2. Lee WM, Squires RH, Nyberg SL, Doo E, Hoofnagle JH. Acute liver failure: summary of a workshop. Hepatology. 2008;47:1401–1415
  3. Choi WC, Arnaout WC, Villamil FG, Demetriou AA, Vierling JM. Comparison of the applicability of two prognostic scoring systems in patients with fulminant hepatic failure. Korean J Intern Med. 2007;22:93–100
  4. Yantorno SE, Kremers WK, Ruf AE, Trentadue JJ, Podesta LG, Villamil FG. MELD is superior to King’s college and Clichy’s criteria to assess prognosis in fulminant hepatic failure. Liver Transpl. 2007;13:822–828
  5. Perkins JD. Another formula to determine the prognosis of patients with acute liver failure. Liver Transpl. 2009;15:986–991
  6. Pacheco-Moreira LF, Balbi E, Enne M, Roma J, Paulino dos Santos K, Annunziata TB, et al. Liver transplantation for acute liver failure: trying to define when transplantation is futile. Transplant proc. 2007;39:3178–3181
  7. Schmidt LE, Larsen FS. MELD score as a predictor of liver failure and death in patients with acetaminophen-induced liver injury. Hepatology. 2007;45:789–796
  8. Singhal S, Jain S, Kohaar I, Singla M, Gondal R, Kar P. Apoptotic mechanisms in fulminant hepatic failure: potential therapeutic target. Appl Immunohistochem Mol Morphol. 2009;17:282–285
  9. Bechmann LP, Marquitan G, Jochum C, Saner F, Gerken G, Canbay A. Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute-on-chronic liver failure. Liver Int. 2008;28:713–716
  10. Bantel H, Ruck P, Gregor M, Schulze-Osthoff K. Detection of elevated caspase activation and early apoptosis in liver diseases. Eur J Cell Biol. 2001;80:230–239
  11. Ward TH, Cummings J, Dean E, Greystoke A, Hou JM, Backen A, et al. Biomarkers of apoptosis. Br J Cancer. 2008;99:841–846
  12. Greystoke A, Cummings J, Ward T, Simpson K, Renehan A, Butt F, et al. Optimisation of circulating biomarkers of cell death for routine clinical use. Ann Oncol. 2008;19:990–995
  13. Hiley C, Fryer A, Bell J, Hume R, Strange RC. The human glutathione S-transferases. Immunohistochemical studies of the developmental expression of Alpha- and Pi-class isoenzymes in liver. Biochem J. 1988;254:255–259
  14. Kamath PS, Kim WR. The model for end-stage liver disease (MELD). Hepatology. 2007;45:797–805
  15. Kamath PS, Wiesner RH, Malinchoc M, Kremers W, Therneau TM, Kosberg CL, et al. A model to predict survival in patients with end-stage liver disease. Hepatology. 2001;33:464–470
  16. O’Grady JG, Gimson AE, O’Brien CJ, Pucknell A, Hughes RD, Williams R. Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure. Gastroenterology. 1988;94:1186–1192
  17. Taylor RM, Davern T, Munoz S, Han SH, McGuire B, Larson AM, et al. Fulminant hepatitis A virus infection in the United States: incidence, prognosis, and outcomes. Hepatology. 2006;44:1589–1597
  18. Bernal W, Wendon J. More on serum phosphate and prognosis of acute liver failure. Hepatology. 2003;38:533–534
  19. O’Grady JG, Alexander GJ, Hayllar KM, Williams R. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology. 1989;97:439–445
  20. Rutherford AE, Hynan LS, Borges CB, Forcione DG, Blackard JT, Lin W, et al. Serum apoptosis markers in acute liver failure: a pilot study. Clin Gastroenterol Hepatol. 2007;5:1477–1483
  21. Knolle PA, Germann T, Treichel U, Uhrig A, Schmitt E, Hegenbarth S, et al. Endotoxin down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells. J Immunol. 1999;162:1401–1407
  22. Kuhla A, Eipel C, Siebert N, Abshagen K, Menger MD, Vollmar B. Hepatocellular apoptosis is mediated by TNFα-dependent Fas/FasLigand cytotoxicity in a murine model of acute liver failure. Apoptosis. 2008;13:1427–1438
  23. Lee JY, Chae DW, Kim SM, Nam ES, Jang MK, Lee JH, et al. Expression of FasL and perforin/granzyme B mRNA in chronic hepatitis B virus infection. J Viral Hepat. 2004;11:130–135
  24. Volkmann X, Anstaett M, Hadem J, Stiefel P, Bahr MJ, Lehner F, et al. Caspase activation is associated with spontaneous recovery from acute liver failure. Hepatology. 2008;47:1624–1633
  25. Krammer PH. CD95’s deadly mission in the immune system. Nature. 2000;407:789–795
  26. Rodriguez I, Matsuura K, Khatib K, Reed JC, Nagata S, Vassalli P. A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection. J Exp Med. 1996;183:1031–1036
  27. Canbay A, Friedman S, Gores GJ. Apoptosis: the nexus of liver injury and fibrosis. Hepatology. 2004;39:273–278

PII: S0168-8278(10)00554-4

doi: 10.1016/j.jhep.2010.04.029

Journal of Hepatology
Volume 53, Issue 4 , Pages 639-647 , October 2010

Article Tools

* Image Usage & Resolution