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Journal of Hepatology
Volume 53, Issue 4
, Pages 752-761
, October 2010
Hepatitis C virus infection: A “liaison a trois” amongst the virus, the host, and chronic low-level inflammation for human survival
References
- . Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest. 2009;119:1745–1754
- . Flying under the radar: the immunobiology of hepatitis C. Annu Rev Immunol. 2007;25:71–99
- . Plasmacytoid dendritic cells move down on the list of suspects: in search of the immune pathogenesis of chronic hepatitis C. J Hepatol. 2008;49:1069–1078
- . Tolerance, danger, and the extended family. Annu Rev Immunol. 1994;12:991–1045
- . Pathogen recognition and innate immunity. Cell. 2006;124:783–801
- . Nod-like proteins in immunity, inflammation and disease. Nat Immunol. 2006;7:1250–1257
- . Intracellular pattern recognition receptors in the host response. Nature. 2006;442:39–44
- . The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol. 2007;19:615–622
- . Leaning from past mistakes: assessing trial quality, power and eligibility in non-renal systemic lupus erythematosus randomized controlled trials. Arthritis Rheum. 2007;56:4294
- Viral and therapeutic control of IFN-β promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci USA. 2006;103:6001–6006
- Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 2009;461:399–401
- Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009;461:798–801
- Binding of hepatitis C virus to CD81. Science. 1998;282:938–941
- Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature. 2007;446:801–805
- Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients. J Exp Med. 2007;204:2423–2437
- . Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C. J Infect Dis. 2005;192:497–503
- . Regulation of T cell immunity by dendritic cells. Cell. 2001;106:263–266
- . Tolerogenic dendritic cells. Annu Rev Immunol. 2003;21:685–711
- Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol. 1999;162:5584–5591
- . Presence of functional dendritic cells in patients chronically infected with hepatitis C virus. Blood. 2004;103:1026–1029
- Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation. J Immunol. 2003;170:5615–5624
- . Hepatitis C virus core selectively suppresses interleukin-12 synthesis in human macrophages by interfering with AP-1 activation. J Biol Chem. 2004;279:43479–43486
- HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science. 2004;305:872–874
- Natural killer cell functional dichotomy in chronic hepatitis b and chronic hepatitis C virus infections. Gastroenterology. 2009;137:1151–1160
- Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J Exp Med. 2002;195:35–41
- . Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J Exp Med. 2002;195:43–49
- . The precursors of memory: models and controversies. Nat Rev Immunol. 2009;9:662–668
- . Homeostasis of memory T cells. Immunol Rev. 2006;211:154–163
- Presence of effector CD8(+) T cells in hepatitis C virus-exposed healthy seronegative donors. J Immunol. 1999;162:6681–6689
- Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV. J Infect Dis. 2008;198:203–212
- Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat Med. 2000;6:578–582
- . Maintenance of HCV-specific T-cell responses in anti body-deficient patients a decade after early therapy. Blood. 2006;107:4570–4571
- Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C. Proc Natl Acad Sci USA. 2007;104:6025–6030
- Subversion of effector CD8(+) T cell differentiation in acute hepatitis C virus infection: exploring the immunological mechanisms. Eur J Immunol. 2004;34:427–437
- Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology. 2007;132:654–666
- Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses. Hepatology. 2006;44:126–139
- . The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol. 2007;8:239–245
- . PD-1 and its ligands in T-cell immunity. Curr Opin Immunol. 2007;19:309–314
- Upregulation of PD-1 expression on HIV-specific CD8(+) T cells leads to reversible immune dysfunction. Nat Med. 2006;12:1198–1202
- PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J Virol. 2006;80:11398–11403
- Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology. 2008;134:1927–1937
- Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. J Virol. 2008;82:5109–5114
- Possible mechanism involving T-lymphocyte response to nonstructural protein-3 in viral clearance in acute hepatitis-C virus-infection. Lancet. 1995;346:1006–1007
- Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J Clin Invest. 1996;98:706–714
- HCV persistence and immune evasion in the absence of memory T cell help. Science. 2003;302:659–662
- Memory CD8(+) T cells are required for protection from persistent hepatitis C virus infection. J Exp Med. 2003;197:1645–1655
- Hepatitis C virus-specific th17 cells are suppressed by virus-induced TGF-β. J Immunol. 2008;181:4485–4494
- Anomalous type 17 response to viral infection by CD8(+) T cells lacking T-bet and eomesodermin. Science. 2008;321:408–411
- . Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. J Exp Med. 2009;206:313–328
- . Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science. 2007;316:612–616
- Differential antigen processing by dendritic cell subsets in vivo. Science. 2007;315:107–111
- . ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells. Nature. 2003;425:397–402
- Chloroquine enhances human CD8(+) T cell responses against soluble antigens in vivo. J Exp Med. 2005;202:817–828
- Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med. 2006;203:883–895
- PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis. J Hepatol. 2006;45:520–528
- . Expression of class I and class II major histocompatibility complex antigens on human hepatocytes. Hepatology. 1988;8:449–454
- Cellular immune selection with hepatitis C virus persistence in humans. J Exp Med. 2005;201:1741–1752
- Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection. Hepatology. 2008;47:1824–1836
- Loss of viral fitness and cross-recognition by CD8(+) T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest. 2009;119:376–386
- Stable cytotoxic T cell escape mutation in hepatitis C virus is linked to maintenance of viral fitness. PLoS Pathog. 2008;4:e1000143
- Escape from HLA-B*08-restricted CD8 T cells by hepatitis C virus is associated with fitness costs. J Virol. 2008;82:11803–11812
- . Direct binding of hepatitis C virus core to gC1qR on CD4(+) and CD8(+) T cells leads to impaired activation of Lck and Akt. J Virol. 2004;78:6409–6419
- Subversion of effector CD8(+) T cell differentiation in acute hepatitis C virus infection: the role of the virus. Eur J Immunol. 2004;34:438–446
- Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol. 2008;48:903–913
- Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection. J Clin Invest. 2004;113:963–972
- Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection. Hepatology. 2006;44:1607–1616
- . Hepatitis C virus (HCV)-specific CD8(+) cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses. J Virol. 2007;81:5882–5892
- . Natural versus adaptive regulatory T cells. Nat Rev Immunol. 2003;3:253–257
- . CD4(+)CD25(+) suppressor T cells: more questions than answers. Nat Rev Immunol. 2002;2:389–400
- . Mechanisms of suppression by suppressor T cells. Nat Immunol. 2005;6:338–344
- . Naturally arising CD4(+) regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004;22:531–562
- . Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol. 2004;4:889–899
- . A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol. 2005;6:1142–1151
- CD25(+)CD4(+) T cells compete with naive CD4(+) T cells for IL-2 and exploit it for the induction of IL-10 production. Int Immunol. 2005;17:279–288
- . Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol. 2005;6:1219–1227
- . CD4(+) CD25(+) Foxp3(+) regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4(+) T cells. Nat Immunol. 2007;8:1353–1362
- Foxp3(+)CD4(+)CD25(+) T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C. Blood. 2006;107:4424–4432
- PD-L1 negatively regulates CD4(+)CD25(+)Foxp3(+) Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J Clin Invest. 2009;119:551–564
- FOXP3 expression in hepatitis C virus-specific CD4(+) T cells during acute hepatitis C. Gastroenterology. 2009;137:1280–1288
- . Regulatory T cells and infection: a dangerous necessity. Nat Rev Immunol. 2007;7:875–888
- Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection. J Hepatol. 2007;47:316–324
- Identification and in vitro expansion of functional antigen-specific CD25(+) FoxP3(+) regulatory T cells in hepatitis C virus infection. J Virol. 2008;82:5043–5053
- . Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis. J Hepatol. 2010;52:315–321
- . Viral hepatocarcinogenesis: from infection to cancer. Liver Int. 2008;28:175–188
- . The pathophysiology of HCV induced B-cell clonal disorders. Autoimmun Rev. 2007;6:581–587
- Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science. 2004;305:1153–1157
- . Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol Rev. 2000;177:134–140
- . The role of chemokine receptors in primary, effector, and memory immune responses. Annu Rev Immunol. 2000;18:593
- . The Th1/Th2 paradigm. Immunol Today. 1997;18:263–266
- Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol. 2007;8:639–646
- . Th17: the third member of the effector T cell trilogy. Curr Opin Immunol. 2007;19:652–657
- . T-H 17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol. 2008;8:337–348
- . The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol. 1999;17:701–738
PII: S0168-8278(10)00562-3
doi: 10.1016/j.jhep.2010.06.003
© 2010 European Association for the Study of the Liver. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of Hepatology
Volume 53, Issue 4
, Pages 752-761
, October 2010
