Journal of Hepatology
Volume 24, Issue 4 , Pages 385-390 , April 1996

Hepatocyte proliferation and serum hepatocyte growth factor levels in patients with alcoholic hepatitis

  • Kenneth J. Hillan

      Affiliations

    • Corresponding Author InformationCorrespondence: Dr. Kenneth J. Hillan, Mail Stop 37, Genentech Inc., 460 Point San Bruno Boulevard, South San Francisco, California 94080, USA.
    • University Department of Pathology, Western Infirmary, Glasgow U.S.A.
    • ,
  • Martin C. Logan

      Affiliations

    • University Department of Pathology, Western Infirmary, Glasgow U.S.A.
    • ,
  • Rod K. Ferrier

      Affiliations

    • University Department of Pathology, Western Infirmary, Glasgow U.S.A.
    • ,
  • George L.A. Bird

      Affiliations

    • Department of Medicine, Gartnavel General Hospital, Glasgow U.S.A.
    • ,
  • Gregory L. Bennett

      Affiliations

    • Genetech Inc., South San Francisco, Ca USA
    • ,
  • Ian C. McKay

      Affiliations

    • Department of Immunology, University of Glasgow U.S.A.
    • ,
  • Roderick N.M. MacSween

      Affiliations

    • University Department of Pathology, Western Infirmary, Glasgow U.S.A.

References 

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  2. Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.. Science. 1991;251:802–804
  3. Sugiyama H, Sugihara J, Murakami N, Koshino Y, Moriwak H, Muto Y. Clinical significance of determination of human hepatocyte growth factor (hHGF) in sera from patients with severe hepatitis.. Acta Hepatol Jpn. 1993;34:493–503
  4. Ishiki Y, Ohnishi H, Muto Y, Matsumoto K, Nakamura T. Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent anti-hepatitis effect in vivo.. Hepatology. 1992;16:1227–1235
  5. Roos F, Terrell TG, Godowski PJ, Chamow SM, Schwall RH. Reductio of α-napthylisothiocyanate-induced hepatotoxicity by recombinant human hepatocyte growth factor.. Endocrinology. 1992;131:2540–2544
  6. Fujiwara K, Nagoshi S, Ohno A, Hirata K, Ohata Y, Mochida S, et al. Stimulation of liver growth by exogenous human hepatocyte growth factor in normal and partially hepatectomized rats.. Hepatology. 1993;18:1443–1449
  7. Tsubouchi H, Kawakami S, Hirono S, Miyazaki H, Kimoto M, Arima T, et al. Prediction of outcome in fulmiant hepatic failure by serum human hepatocyte growth factor.. Lancet. 1992;340:307
  8. Gerdes J, Becker MHG, Key G, Cattoretti G. Immunohistochemical detection of tumour growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues.. J Pathol. 1992;168:85–86
  9. Lokker NA, Mark MR, Luis EA. Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.. EMBO J. 1992;11:2503–2510
  10. Mizuno Y, Inoue H, Hagiya , Shimizu S, Nose T, Shimohigashi Y, et al. Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hepatocyte growth factor.. J Biol Chem. 1994;269:1131–1136
  11. Lokker NA, Presta LG, Godowski PJ. Mutational analyses and molecular modelling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interactions with the c-Met receptro. Prot Eng. 1994;7:895–903
  12. Matsumoto K, Takehara T, Inoue H, Hagiya M, Shimizu S, Nakamura T. Deletion of kringle domains or the N-terminal hairpin structure in hepatocyte growth factor results in marked decreases in related biological activities.. Biochem Biophys Res Commun. 1991;181:691–699
  13. Matsumoto K, Nakamura T. Molecular structure, roles in liver regeneration, and other biological functions.. Critical Reviews in Oncogenesis. 1992;3:27–54
  14. Shiota G, Wang TC, Nakamura T, Schmidt EV. Hepatocyte growth factor in transgenic mice: effects on hepatocyte growth, liver regeneration and gene expression.. Hepatology. 1994;19:962–972
  15. Tomiya T, Nagoshi S, Fujiwara K. Significance of serum human hepatocyte growth factors levels in patients with hepatic failure.. Hepatology. 1992;15:1–4
  16. Tsubouchi H, Niitani Y, Hirmo ST, Nakayama H, Gohda E, Arakaki N, et al. Levels of human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme-linked immunosorbent assay.. Hepatology. 1991;13:1–5
  17. Tomiya T, Tani M, Yamada S, Hayashi S, Umeda N, Fujiwara K. Serum hepatocyte growth factor levels in hepatectomized and non-hepatectomized surgical patients.. Gastroenterology. 1992;103:1621–1624
  18. Appasamy R, Tanabe M, Murase N, Zarnegar R, Vanthiel DH, Ventkataraman R, et al. Hepatocyte growth factor, blood clearance, organ uptake and biliary excretion in normal and partially hepatectomized rats.. Lab Invest. 1993;68:270–276
  19. Zioncheck TF, Richardson L, DeGuzman GG, Modi NB, Hansen SE, Godowski PJ. The pharmacokinetics, tissue localisation and metabolic processing of recombinant human hepatocyte growth factor after intravenous administration in rats.. Endocrinology. 1994;134:1879–1887
  20. Rose DSC, Maddox PH, Brown DC. Which proliferation markers for routine immunohistology? A comparison of five antibodies.. J Clin Pathol. 1994;47:1010–1014
  21. Carter EA, Wands JR. Ethanol inhibits hormone stimulated hepatocyte DNA synthesis.. Biochem Biophys Res Commun. 1985;128:767–774
  22. Fang JWS, Bird GLA, Nakamura T, Davis GL, Lau JYN. Hepatocyte proliferative response as a prognostic marker in acute alcoholic hepatitis.. Lancet. 1994;343:820–824

PII: S0168-8278(96)80157-7

Journal of Hepatology
Volume 24, Issue 4 , Pages 385-390 , April 1996

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