Entecavir plus Biejia-Ruangan compound reduces the risk of hepatocellular carcinoma in Chinese patients with chronic hepatitis B

variables are expressed as medians and interquartile ranges (IQRs) and compared using the Mann-Whitney test. Categorical variables are presented as numbers (percentages) and compared using the chi-square or Fisher’s exact test, if appropriate. A two-tailed p value of <0.05 is considered statistically significant. variables are expressed as medians and interquartile ranges (IQRs) and compared using the Mann-Whitney test. Categorical variables are presented as numbers (percentages) and compared using the chi-square or Fisher’s exact test, if appropriate. A two-tailed p value of <0.05 is considered statistically significant.

The HRs indicate the incidence of clinical outcomes in the ETV+BRC group as compared with the ETV group, the p values are calculated using the Log-rank test and the Cox proportional regression. A two-tailed p value of <0.05 is considered statistically significant.
BRC, Biejia-Ruangan compound; CI, confidence interval; ETV, entecavir; HCC, hepatocellular carcinoma; HR, hazard ratio; ITT, intention-to-treat. The HRs indicate the incidence of clinical outcomes in the ETV+BRC group as compared with the ETV group, the p values are calculated using the Log-rank test and the Cox proportional regression. A two-tailed p value of <0.05 is considered statistically significant.
BRC, Biejia-Ruangan compound; CI, confidence interval; ETV, entecavir; HCC, hepatocellular carcinoma; HR, hazard ratio; PP, per-protocol. The re-defined cutoff values of baseline age, BMI, and HBsAg level were 44 years, 26.9 kg/m 2 , and 5000 IU/mL. Regarding HBsAg level, there is no well-documented definition for classifying high and low categories, 5839 IU/mL of HBsAg level deduced from Kaplan-Meier curve was poor clinical usability, and percentage of patients with HBsAg≥5839 were relatively low, so 5000 IU/mL was chosen as the cutoff value.
The p values are calculated using the Log-rank test. A two-tailed p value of <0.05 is considered statistically significant. BMI, body mass index. Each square represents the estimated HR, the horizontal lines represent the 95% CIs, and the diamond corresponds to the estimated HR and the 95% CI for the entire population. The p value is calculated using the Cox proportional regression or Fisher's exact test, if appropriate. The p value for interaction is analyzed by use of the Breslow-Day test. A two-tailed p value of <0.05 is considered statistically significant. BMI, body mass index; BRC, Biejia-Ruangan compound; CI, confidence interval; ETV, entecavir; HCC, hepatocellular carcinoma; HR, hazard ratio; ITT, intention-to-treat; LC, liver cirrhosis; LSM, liver stiffness measurement. Each square represents the estimated HR, the horizontal lines represent the 95% CIs, and the diamond corresponds to the estimated HR and the 95% CI for the entire population. The p value is calculated using the Cox proportional regression or Fisher's exact test, if appropriate. The p value for interaction is analyzed by use of the Cochran-Mantel-Haenszel test. A two-tailed p value of <0.05 is considered statistically significant.
A two-tailed p value of <0.05 is considered statistically significant.