| |
Article Title |
Author(s) |
Type (Status) |
Available Online |
|
Influence of Mutations in Hepatitis B Virus Surface Protein on Viral Antigenicity and Phenotype in Occult HBV Strains from Blood Donors
DOI: 10.1016/j.jhep.2012.05.009
Abstract: Background & aims: This study aimed to investigate mutations in the hepatitis B surface protein (HBsAg) in occult hepatitis B virus (HBV) infection (OBI) and their influence on viral ant...
|
Cheng-Hao Huang,
Quan Yuan,
Pei-Jer Chen,
Ya-Li Zhang,
Chang-Rong Chen,
Qing-Bing Zheng,
Shiou-Hwei Yeh,
Hai Yu,
Yu Xue,
Yi-Xin Chen,
Ping-Guo Liu,
Sheng-Xiang Ge,
Jun Zhang,
Ning-Shao Xia
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
25 May 2012 |
|
Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism
DOI: 10.1016/j.jhep.2012.05.006
|
Tian Lan,
Anuradha Rao,
Jamie Haywood,
Nancy D. Kock,
Paul A. Dawson,
Saul J. Karpen
et al.
|
Editorial
(In Press Accepted Manuscript)
|
24 May 2012 |
|
Long-term Clinical Outcome of the Surgically Resected Intraductal Papillary Neoplasm of the Bile Duct
DOI: 10.1016/j.jhep.2012.05.008
Abstract: Background & Aims: Intraductal papillary neoplasm of the bile duct (IPNB) is a biliary neoplasm with predominant intraductal papillary growth and various degrees of malignant transformat...
|
Geunyoung Jung,
Kwang-Min Park,
Seung Soo Lee,
Eunsil Yu,
Seung-Mo Hong,
Jihun Kim
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
24 May 2012 |
|
Inflammasomes in liver diseases
DOI: 10.1016/j.jhep.2012.03.035
Abstract: Inflammation is a common element in the pathogenesis of most chronic liver diseases that lead to fibrosis and cirrhosis. Inflammation is characterized by activation of innate immune cells an...
|
Gyongyi Szabo,
Timea Csak
|
Review article
(In Press Accepted Manuscript)
|
24 May 2012 |
|
Chronic hepatitis B in children and adolescents
DOI: 10.1016/j.jhep.2012.03.036
Abstract: Incidence of chronic hepatitis B is declining thanks to universal immunization programs. Nevertheless, hepatitis B virus infection is still one of the most important causes of liver disease ...
|
Massimiliano Paganelli,
Xavier Stephenne,
Etienne M. Sokal
|
Review article
(In Press Accepted Manuscript)
|
24 May 2012 |
|
D-Livering The Message: The Importance of Vitamin D Status in Chronic Liver Disease
DOI: 10.1016/j.jhep.2012.04.033
Abstract: Vitamin D is synthesized predominantly in the liver and functions as an important secosteroid hormone with pleiotropic effects. While its key regulatory role in calcium and bone homeostasis ...
|
Matthew T Kitson,
Stuart K. Roberts
|
Review article
(In Press Accepted Manuscript)
|
24 May 2012 |
|
A Randomized Controlled Trial of Radiofrequency Ablation and Surgical Resection in the Treatment of Small Hepatocellular Carcinoma
DOI: 10.1016/j.jhep.2012.05.007
Abstract: Background & Aims: The aim of this study was to compare the efficacy of radiofrequency ablation (RFA) and surgical resection (RES) in the treatment of small hepatocellular carcinoma (HCC...
|
Kai Feng,
Jun Yan,
Xiaowu Li,
Feng Xia,
Kuansheng Ma,
Shuguang Wang,
Ping Bie,
Jiahong Dong
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
24 May 2012 |
|
Twenty years of adult liver transplantation for acute liver failure in Europe: Achievements, lessons and concerns
DOI: 10.1016/j.jhep.2012.05.005
|
Daniel Shouval
|
Discussion
(In Press Accepted Manuscript)
|
23 May 2012 |
|
Assessment of risk for nonhepatic surgery in cirrhotic patients
DOI: 10.1016/j.jhep.2012.03.037
|
Prashant Bhangui,
Alexis Laurent,
Roland Amathieu,
Daniel Azoulay
|
Review article
(In Press Accepted Manuscript)
|
23 May 2012 |
|
Reply to “Liver in mythology: A different version of Tityos’ myth” Liver, snakes and myths
DOI: 10.1016/j.jhep.2012.04.011
I greatly appreciate the letter written by Luigi Roffi, providing us with further information on the less-known myth of the Giant Tityus, cited in our manuscript and in the paper by Tiniakos et al.. ...
|
Michele A. Riva
|
Correspondence
(In Press Uncorrected Proof)
|
22 May 2012 |
|
The danger of comparing survival rates from chronic liver disease cohorts with differing levels of organ failure severity
DOI: 10.1016/j.jhep.2012.04.009
We thank Thomson and colleagues for their comments on our recent article , one of the largest prospective studies ever published on intensive care provision and cost utilisation for patients with chro...
|
Mark J.W. McPhail,
Debbie L. Shawcross,
Julia A. Wendon
|
Correspondence
(In Press Uncorrected Proof)
|
21 May 2012 |
|
Liver Regeneration
DOI: 10.1016/j.jhep.2012.04.016
|
Nelson Fausto,
Jean S. Campbell,
Kimberly J. Riehle
|
Discussion
(In Press Accepted Manuscript)
|
21 May 2012 |
|
Cholestasis-Induced Pruritus Treated with Ultraviolet B Phototherapy: An Observational Case Series Study
DOI: 10.1016/j.jhep.2012.04.023
Abstract: Background & aims: Pruritus is a disabling complication of cholestatic liver disorders. Its management remains challenging. Ultraviolet B (UVB) phototherapy has been successfully used to...
|
Sofie Decock,
Rik Roelandts,
Werner Van Steenbergen,
Wim Laleman,
David Cassiman,
Chris Verslype,
Johan Fevery,
Jos Van Pelt,
Frederik Nevens
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
Hepatitis C Virus (HCV) Protein Expression Enhances Hepatic Fibrosis in HCV Transgenic Mice Exposed to a Fibrogenic Agent
DOI: 10.1016/j.jhep.2012.04.019
Abstract: Background & aims: During chronic HCV infection, activation of fibrogenesis appears to be principally related to local inflammation. However, the direct role of hepatic HCV protein expre...
|
Philippe Chouteau,
Nicole Defer,
Alexandre Florimond,
Julien Caldéraro,
Martin Higgs,
Aurore Gaudin,
Emilie Mérour,
Daniel Dhumeaux,
Hervé Lerat,
Jean-Michel Pawlotsky
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
OV6+ tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma
DOI: 10.1016/j.jhep.2012.04.024
Abstract: Background & aims: Accumulating results suggest the involvement of tumor-initiating cells (T-ICs) in cancer genesis, but whether liver T-ICs contribute to HCC invasion and metastasis rem...
|
Wen Yang,
Chao Wang,
Yan Lin,
Qiong Liu,
Le-xing Yu,
Liang Tang,
He-Xin Yan,
Jing Fu,
Yao Chen,
Hui-Lu Zhang,
Liang Tang,
Long-Yi Zheng,
Ya-Qin He,
Yu-Qiong Li,
Fu-Quan Wu,
Shan-Shan Zou,
Zhong Li,
Meng-Chao Wu,
Gen-Sheng Feng,
Hong-Yang Wang
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: Proof of concept and first application in a large population
DOI: 10.1016/j.jhep.2012.04.025
Abstract: Background & aims: Time-dependent statistics have been used to assess liver fibrosis progression (LFP) in liver diseases from birth to first biopsy, in a limited number of patients. Non-...
|
Thierry Poynard,
Mona Munteanu,
Olivier Deckmyn,
Yen Ngo,
Fabienne Drane,
Jean Marie Castille,
Chantal Housset,
Vlad Ratziu,
Françoise Imbert-Bismut
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
The Laennec staging system for histological sub-classification of cirrhosis is useful for stratification of prognosis in patients with liver cirrhosis
DOI: 10.1016/j.jhep.2012.04.029
Abstract: Background s & Aims: The clinical severity of cirrhosis varies widely. We investigated whether histological sub-classification of cirrhosis using the Laennec system can discriminate diff...
|
Seung Up Kim,
Hyun Jung Oh,
Ian R. Wanless,
Sarah Lee,
Kwang-Hyub Han,
Young Nyun Park
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma
DOI: 10.1016/j.jhep.2012.04.020
Abstract: Background & aims: Forkhead box M1 (FoxM1) is a master regulator of tumor metastasis that plays an important role in the development of hepatocellular carcinoma (HCC). However, whether o...
|
Xia Limin,
Huang Wenjie,
Tian Dean,
Zhu Hongwu,
Zhang Yongguo,
Hu Hao,
Fan Daiming,
Nie Yongzhan,
Wu Kaichun
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
Unexpectedly high proportion of drug users and men having sex with men who develop chronic hepatitis B infection
DOI: 10.1016/j.jhep.2012.04.030
Abstract: Background: In low endemic countries, most hepatitis B virus (HBV) infections are found in adult behavioural risk groups, such as drug users (DU) and men having sex with men (MSM). These ris...
|
Robin van Houdt,
Sylvia M. Bruisten,
Arjen G.C.L. Speksnijder,
Maria Prins
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
MicroRNA-214 downregulation contributes to tumor angiogenesis via inducing secretion of hepatoma-derived growth factor in human hepatoma
DOI: 10.1016/j.jhep.2012.04.031
Abstract: Background & aims: Unusual hypervascularity is a hallmark of human hepatocellular carcinoma (HCC). Although microRNA-214 (miR-214) is upregulated in other human cancers, it is downregula...
|
Tsung-Chieh Shih,
Yin-Jing Tien,
Chih-Jen Wen,
Ta-Sen Yeh,
Ming-Chin Yu,
Chia-Hao Huang,
Yun-Shien Lee,
Tzu-Chen Yen,
Sen-Yung Hsieh
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
Role of Toll-like receptor 2 in the immune response against hepadnaviral infection
DOI: 10.1016/j.jhep.2012.05.004
Abstract: Background and aims: The Toll-like receptor 2 (TLR2) has recently been recognized to play an important role in the pathogenesis of chronic hepatitis B virus (HBV) infection. In the present s...
|
Xiaoyong Zhang,
Zhiyong Ma,
Hongyan Liu,
Jia Liu,
Zhongji Meng,
Ruth Broering,
Dongliang Yang,
Joerg F. Schlaak,
Michael Roggendorf,
Mengji Lu
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
Prospective assessment of renal histopathological lesions in patients with end-stage liver disease: effects on long-term renal function after liver transplantation
DOI: 10.1016/j.jhep.2012.04.028
Abstract: Background: The incidence of organic renal lesions in patients with end-stage liver disease is unknown. The goal of this study was to make a prospective evaluation of renal histological lesi...
|
Yvon Calmus,
Filoména Conti,
Philippe Cluzel,
Gary Hill,
Corinne Antoine,
Olivier Scatton,
Olivier Soubrane,
Denis Glotz,
Evangéline Pillebout,
Dominique Nochy
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
High prevalence of occult hepatitis B virus infection in children born to HBsAg-positive mothers despite prophylaxis with hepatitis B vaccination and HBIG
DOI: 10.1016/j.jhep.2012.04.021
Abstract: Background: Occult hepatitis B virus (HBV) infection is a well-recognized clinical entity characterized by the detection of HBV DNA in serum and/or in liver in the absence of detectable hepa...
|
S. Shahmoradi,
Y. Yahyapour,
M. Mahmoodi,
S.M. Alavian,
Z. Fazeli,
S.M. Jazayeri
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways
DOI: 10.1016/j.jhep.2012.04.026
Abstract: Background & aims: Aberrant activation of the AKT oncogenic pathway and downregulation of the Sprouty 2 (Spry2) tumor suppressor gene are frequently observed molecular events in human he...
|
Chunmei Wang,
Salvatore Delogu,
Coral Ho,
Susie A. Lee,
Bing Gui,
Lijie Jiang,
Sara Ladu,
Antonio Cigliano,
Frank Dombrowski,
Matthias Evert,
Diego F. Calvisi,
Xin Chen
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
Treatment of Recurrent HCV Infection Following Liver Transplantation: Results of a Multicenter, Randomized, versus placebo, Trial of ribavirin alone as maintenance therapy after one year of Peginterferon Alfa-2A plus Ribavirin
DOI: 10.1016/j.jhep.2012.04.022
Abstract: Aim: To determine the effect of maintenance therapy with ribavirin alone, after a year of combined peginterferon-alfa 2a (PEG-IFNα-2a) and ribavirin therapy, on viral response and liver hist...
|
Yvon Calmus,
Christophe Duvoux,
Georges Pageaux,
Philippe Wolf,
Lionel Rostaing,
Claire Vanlemmens,
Danielle Botta-Fridlund,
Sébastien Dharancy,
Jean Gugenheim,
François Durand,
Martine Néau-Cransac,
Olivier Boillot,
Olivier Chazouillères,
Laurence Samelson,
Karim Boudjema,
Didier Samuel
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
Insulin resistance undermines the advantages of IL28B polymorphism in the pegylated interferon alpha-2b and ribavirin treatment of chronic hepatitis C patients with genotype 1
DOI: 10.1016/j.jhep.2012.04.027
Abstract: Background and aims: Recent studies have suggested that insulin resistance exerts a strong influence on chronic hepatitis C virus (HCV) infection. We analyzed pretreatment factors useful for...
|
Eiichi Ogawa,
Norihiro Furusyo,
Masayuki Murata,
Hiroaki Ikezaki,
Takeshi Ihara,
Takeo Hayashi,
Kazuhiro Toyoda,
Hiroaki Taniai,
Kyoko Okada,
Mosaburo Kainuma,
Jun Hayashi
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
21 May 2012 |
|
Single nucleotide polymorphisms and risk of hepatocellular carcinoma in cirrhosis
DOI: 10.1016/j.jhep.2012.02.035
Summary: Liver carcinogenesis is a complex and multi-factorial process, in which both environmental and genetic features interfere and contribute to malignant transformation. Patients with cirrhosis a...
|
Pierre Nahon,
Jessica Zucman-Rossi
|
Review article
(In Press Accepted Manuscript)
|
18 May 2012 |
|
EVOLUTION OF INDICATIONS AND RESULTS OF LIVER TRANSPLANTATION IN EUROPE. A Report from the European Liver Transplant Registry (ELTR)
DOI: 10.1016/j.jhep.2012.04.015
|
René Adam,
Vincent Karam,
Valérie Delvart,
John O’Grady,
Darius Mirza,
Jurgen Klempnauer,
Denis Castaing,
Peter Neuhaus,
Neville Jamieson,
Mauro Salizzoni,
Stephen Pollard,
Jan Lerut,
Andreas Paul,
Juan Carlos Garcia-Valdecasas,
Fernando San Juan Rodríguez,
Andrew Burroughs,
all the contributing centers (www.eltr.org) the European Liver Intestine Transplant Association (ELITA)
et al.
|
Discussion
(In Press Accepted Manuscript)
|
18 May 2012 |
|
Gap junctions and non-neoplastic liver disease
DOI: 10.1016/j.jhep.2012.02.036
Abstract: Because of their critical role as goalkeepers of hepatic homeostasis, gap junctions are frequent targets in liver disease. This concept has been demonstrated on many occasions in the light o...
|
Mathieu Vinken
|
Review article
(In Press Accepted Manuscript)
|
18 May 2012 |
|
Successful mutation-specific chaperone therapy with 4-phenylbutyrate in a child with progressive familial intrahepatic cholestasis type 2
DOI: 10.1016/j.jhep.2012.04.017
Summary: Background & aims: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is due to mutations in ABCB11 encoding the canalicular bile salt export pump (BSEP) of hepatocyte. Liver tr...
|
Emmanuel Gonzales,
Brigitte Grosse,
Doris Cassio,
Anne Davit-Spraul,
Monique Fabre,
Emmanuel Jacquemin
et al.
|
Short communication
(In Press Accepted Manuscript)
|
18 May 2012 |
|
Liver transplantation for hepatocellular carcinoma in non-cirrhotic livers regardless of the number and size of tumours?
DOI: 10.1016/j.jhep.2012.05.001
Hepatocellular carcinoma (HCC) is a major health problem worldwide , which continues to increase because of viral hepatitis B and C epidemics, but also because of alcoholic and non-alcoholic liver di...
|
Thomas Decaens,
Alexis Laurent,
Alain Luciani
|
Editorial
(In Press Uncorrected Proof)
|
14 May 2012 |
|
EASL Recognition Awardee 2012: Professor Helmer Ring-Larsen
DOI: 10.1016/j.jhep.2012.04.013
It is a privilege and an honour to introduce, on behalf of EASL, Professor Helmer Ring-Larsen, on the occasion of the EASL 2012 recognition award ceremony.
|
Carlo Merkel
|
Editorial
(In Press Uncorrected Proof)
|
11 May 2012 |
|
Hepatocyte-like cells differentiated from human induced pluripotent stem cells (iHLCs) are permissive to hepatitis C virus (HCV) infection: HCV study gets personal
DOI: 10.1016/j.jhep.2012.04.012
|
Karim Si-Tayeb,
Jean-Charles Duclos-Vallée,
Marie-Anne Petit
|
Discussion
(In Press Accepted Manuscript)
|
07 May 2012 |
|
Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation
DOI: 10.1016/j.jhep.2012.03.023
Background & Aims: Lymph nodes (LNs) play a critical role in host defence against pathogens. In rodents, lymphatic anatomy and drainage have been characterized for many different organs. Surprisin...
|
Louise Barbier,
Szun Szun Tay,
Claire McGuffog,
James A. Triccas,
Geoffrey W. McCaughan,
David G. Bowen,
Patrick Bertolino
et al.
|
Full-length article
(In Press Corrected Proof)
|
27 April 2012 |
|
Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism
DOI: 10.1016/j.jhep.2012.03.025
Background & Aims: Blocking intestinal bile acid (BA) absorption by inhibiting or inactivating the apical sodium-dependent BA transporter (Asbt) classically induces hepatic BA synthesis. In contra...
|
Tian Lan,
Anuradha Rao,
Jamie Haywood,
Nancy D. Kock,
Paul A. Dawson
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
27 April 2012 |
|
IBD is associated with an increase in carcinoma in PSC irrespective of the presence of dominant bile duct stenosis
DOI: 10.1016/j.jhep.2012.02.034
We have read with great interest the paper by Rudolph et al.. The authors have prospectively studied a large cohort of Primary Sclerosing Cholangitis (PSC) patients for up to two decades and identifie...
|
Marcel Janse,
Laetitia E. Lamberts,
Robert C. Verdonk,
Rinse K. Weersma
|
Correspondence
(In Press Corrected Proof)
|
24 April 2012 |
|
Regulatory T cells and autoimmune hepatitis: Defective cells or a hostile environment?
DOI: 10.1016/j.jhep.2012.04.005
Autoimmunity occurs when genetically predisposed individuals are exposed to environmental factors that trigger immune responses to self-antigens. The immune system protects the host by recognising and...
|
Ye H. Oo,
David H. Adams
|
Editorial
(In Press Corrected Proof)
|
23 April 2012 |
|
Focus
DOI: 10.1016/j.jhep.2012.04.006
Ilya Metchnikoff is widely hailed as the father of modern immunology based on his prescient characterization in the late 19th Century of the macrophage’s roles in phagocytic clearance of infections, t...
|
Scott L. Friedman
|
Discussion
(In Press Corrected Proof)
|
23 April 2012 |
|
Reply to “IBD is associated with an increase in carcinoma in PSC irrespective of the presence of dominant bile duct stenosis”
DOI: 10.1016/j.jhep.2012.04.007
In a retrospective cohort, Janse et al. analyzed the association of malignancies with the presence of inflammatory bowel disease (IBD) and dominant stenosis (DS) in patients with primary sclerosing c...
|
Daniel N. Gotthardt,
Adolf Stiehl
|
Correspondence
(In Press Corrected Proof)
|
23 April 2012 |
|
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
DOI: 10.1016/j.jhep.2012.03.031
Background & Aims: A limited number of genetic risk factors have been reported in primary sclerosing cholangitis (PSC). To discover further genetic susceptibility factors for PSC, we followed up o...
|
Trine Folseraas,
Espen Melum,
Philipp Rausch,
Brian D. Juran,
Eva Ellinghaus,
Alexey Shiryaev,
Jon K. Laerdahl,
David Ellinghaus,
Christoph Schramm,
Tobias J. Weismüller,
Daniel Nils Gotthardt,
Johannes Roksund Hov,
Ole Petter Clausen,
Rinse K. Weersma,
Marcel Janse,
Kirsten Muri Boberg,
Einar Björnsson,
Hanns-Ulrich Marschall,
Isabelle Cleynen,
Philip Rosenstiel,
Kristian Holm,
Andreas Teufel,
Christian Rust,
Christian Gieger,
H-Erich Wichmann,
Annika Bergquist,
Euijung Ryu,
Cyriel Y. Ponsioen,
Heiko Runz,
Martina Sterneck,
Severine Vermeire,
Ulrich Beuers,
Cisca Wijmenga,
Erik Schrumpf,
Michael P. Manns,
Konstantinos N. Lazaridis,
Stefan Schreiber,
John F. Baines,
Andre Franke,
Tom H. Karlsen
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
19 April 2012 |
|
Liver transplantation for acute liver failure in Europe: Outcomes over 20 years from the ELTR database
DOI: 10.1016/j.jhep.2012.03.017
Background & Aims: Liver transplantation for acute liver failure (ALF) still has a high early mortality. We evaluated changes during 20years, and identified risk factors for poor outcome. Methods:...
|
Giacomo Germani,
Eleni Theocharidou,
Renè Adam,
Vincent Karam,
Julia Wendon,
John O’Grady,
Patrizia Burra,
Marco Senzolo,
Darius Mirza,
Denis Castaing,
Jurgen Klempnauer,
Stephen Pollard,
Andreas Paul,
Jacques Belghiti,
Emmanuel Tsochatzis,
Andrew K. Burroughs
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
19 April 2012 |
|
Liver transplantation for unresectable hepatocellular carcinoma in normal livers
DOI: 10.1016/j.jhep.2012.03.022
Background & Aims: The role of liver transplantation in the treatment of hepatocellular carcinoma in livers without fibrosis/cirrhosis (NC-HCC) is unclear. We aimed to determine selection criteria...
|
Hynek Mergental,
Rene Adam,
Bo-Goran Ericzon,
Piotr Kalicinski,
Ferninand Mühlbacher,
Krister Höckerstedt,
Jürgen L. Klempnauer,
Styrbjörn Friman,
Christoph E. Broelsch,
Georges Mantion,
Carlos Fernandez-Sellez,
Bart van Hoek,
Josef Fangmann,
Jacques Pirenne,
Paolo Muiesan,
Alfred Königsrainer,
Darius F. Mirza,
Jan Lerut,
Olivier Detry,
Yves-Ptrice Le Treut,
Vincenzo Mazzaferro,
Florian Löhe,
Marina Berenguer,
Pierre-Alain Clavien,
Xavier Rogiers,
Jacques Belghiti,
Laslo Kóbori,
Patrizia Burra,
Philippe Wolf,
Wolfgang Schareck,
Przemyslaw Pisarski,
Aksel Foss,
Franco Filipponi,
Marek Krawczyk,
Martin Wolff,
Jan M. Langrehr,
Keith Rolles,
Neville Jamieson,
Wim C.J. Hop,
Robert J. Porte
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
19 April 2012 |
|
Alpha-fetoprotein acts as a novel signal molecule and mediates transcription of Fn14 in human hepatocellular carcinoma
DOI: 10.1016/j.jhep.2012.03.029
Background & Aims: The function of cytoplasmic AFP as a regulatory factor in the growth of tumor cells has been well defined. However, its precise mechanism of action and its clinical significance...
|
Shanshan Wang,
Wei Jiang,
Xiangmei Chen,
Chao Zhang,
Hui Li,
Wenting Hou,
Zhongmin Liu,
Michael A. McNutt,
Fengmin Lu,
Gang Li
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
19 April 2012 |
|
Interferon responses and spontaneous HCV clearance: Is it all a matter of fat?
DOI: 10.1016/j.jhep.2012.04.003
Shortly after the discovery of the hepatitis C virus (HCV), it was recognized that the virus interacts intimately with the lipid machinery of the cell. Lipids are involved in almost all stages of the ...
|
Jordan J. Feld
|
Editorial
(In Press Corrected Proof)
|
18 April 2012 |
|
Human pluripotent stem cell derived hepatocytes support complete replication of hepatitis C virus
DOI: 10.1016/j.jhep.2012.03.030
Background & Aims: Worldwide, about 180million people are chronically infected with the hepatitis C virus (HCV). Current in vitro culture systems for HCV depend chiefly on human hepatoma cell line...
|
Philip Roelandt,
Susan Obeid,
Jan Paeshuyse,
Jolien Vanhove,
Alfons Van Lommel,
Yaakov Nahmias,
Frederik Nevens,
Johan Neyts,
Catherine M Verfaillie
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
18 April 2012 |
|
An in situ molecular signature to predict early recurrence in hepatitis B virus-related hepatocellular carcinoma
DOI: 10.1016/j.jhep.2012.03.027
Background & Aims: To develop an in situ molecular signature to predict postsurgical recurrence in hepatocellular carcinoma (HCC) patients. Methods: Immunohistochemistry was performed using tissue...
|
Jing Xu,
Tong Ding,
Qi He,
Xing-Juan Yu,
Wen-Chao Wu,
Wei-Hua Jia,
Jing-Ping Yun,
Ying Zhang,
Ming Shi,
Chun-Kui Shao,
Wei-Dong Pan,
Xiao-Yu Yin,
Jun Min,
Shi-Mei Zhuang,
Limin Zheng
et al.
|
Full-length article
(In Press Corrected Proof)
|
18 April 2012 |
|
Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α and HNF-4α in rat liver
DOI: 10.1016/j.jhep.2012.03.028
Abstract: Background: Folate and cobalamin are methyl donors needed for synthesizing methionine, which is the precursor of S-adenosylmethionine, the substrate of methylation in epigenetic and epigenom...
|
Shabnam Pooya,
Sébastien Blaise,
Maira Moreno Garcia,
Jean Giudicelli,
Jean-Marc Alberto,
Rosa-Maria Guéant-Rodriguez,
Elise Jeannesson,
Naig Gueguen,
Aude Bressenot,
Bénédicte Nicolas,
Yves Malthiery,
Jean-Luc Daval,
Laurent Peyrin-Biroulet,
Jean-Pierre Bronowicki,
Jean-Louis Guéant
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
18 April 2012 |
|
ARFI, FibroScan, ELF, and their combinations in the assessment of liver fibrosis: A prospective study
DOI: 10.1016/j.jhep.2012.03.016
Background & Aims: Our aim was to evaluate a serologic marker (ELF) and two ultrasound-based methods (FibroScan and ARFI), as well as their combinations, in the assessment of liver fibrosis. Metho...
|
Gonzalo Crespo,
Guillermo Fernández-Varo,
Zoe Mariño,
Gregori Casals,
Rosa Miquel,
Stella M. Martínez,
Rosa Gilabert,
Xavier Forns,
Wladimiro Jiménez,
Miquel Navasa
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
18 April 2012 |
|
National patterns and predictors of liver biopsy use for management of hepatitis C
DOI: 10.1016/j.jhep.2012.03.021
Background & Aims: Liver biopsy remains the standard, recommended method for assessing liver damage associated with chronic hepatitis C (HCV) infection. However, there is considerable debate about...
|
Erik J. Groessl,
Lin Liu,
Samuel B. Ho,
Fasiha Kanwal,
Allen L. Gifford,
Steven M. Asch
et al.
|
Full-length article
(In Press Corrected Proof)
|
18 April 2012 |
|
Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence
DOI: 10.1016/j.jhep.2012.03.012
Background & Aims: Mitochondrial isoenzyme of creatine kinase (MtCK) is reportedly highly expressed in hepatocellular carcinoma (HCC). Clinical relevance of serum MtCK activity in patients with HC...
|
Yoko Soroida,
Ryunosuke Ohkawa,
Hayato Nakagawa,
Yumiko Satoh,
Haruhiko Yoshida,
Hiroto Kinoshita,
Ryosuke Tateishi,
Ryota Masuzaki,
Kenichiro Enooku,
Shuichiro Shiina,
Takahisa Sato,
Shuntaro Obi,
Tadashi Hoshino,
Ritsuko Nagatomo,
Shigeo Okubo,
Hiromitsu Yokota,
Kazuhiko Koike,
Yutaka Yatomi,
Hitoshi Ikeda
et al.
|
Full-length article
(In Press Corrected Proof)
|
18 April 2012 |
|
Severe hyponatremia is a better predictor of mortality than MELDNa in patients with cirrhosis and refractory ascites
DOI: 10.1016/j.jhep.2012.03.018
Background & Aims: The MELDNa score was developed to improve the prognostic value of the MELD score in cirrhosis and was built for serum sodium concentrations numerically capped between 125 and 14...
|
Thomas Sersté,
Thierry Gustot,
Pierre-Emmanuel Rautou,
Claire Francoz,
Hassane Njimi,
Francois Durand,
Dominique Valla,
Didier Lebrec,
Richard Moreau
et al.
|
Full-length article
(In Press Corrected Proof)
|
18 April 2012 |
|
A survey of patterns of practice and perception of NAFLD in a large sample of practicing gastroenterologists in France
DOI: 10.1016/j.jhep.2012.03.019
Background & Aims: Most studies on non-alcoholic fatty-liver disease (NAFLD) originate from tertiary care centers with an academic interest. How this emerging entity is accepted and managed by a w...
|
Vlad Ratziu,
Jean-François Cadranel,
Lawrence Serfaty,
Jacques Denis,
Christophe Renou,
Patrick Delassalle,
Carole Bernhardt,
Gabriel Perlemuter
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
18 April 2012 |
|
Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD)
DOI: 10.1016/j.jhep.2012.03.024
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a cardiovascular risk factor. Although modest alcohol consumption may reduce the risk for cardiovascular mortality, whether patients...
|
Winston Dunn,
Arun J. Sanyal,
Elizabeth M. Brunt,
Aynur Unalp-Arida,
Michael Donohue,
Arthur J. McCullough,
Jeffrey B. Schwimmer
et al.
|
Full-length article
(In Press Corrected Proof)
|
18 April 2012 |
|
Immediate vs. delayed treatment in patients with acute hepatitis C based on IL28B polymorphism: A model-based analysis
DOI: 10.1016/j.jhep.2012.03.020
Background & Aims: Timing of treatment initiation in acute hepatitis C (AHC) patients is unclear. Spontaneous viral clearance argues for a “watch-and-wait” strategy. However, early initiation of t...
|
Sylvie Deuffic-Burban,
Hélène Castel,
Johannes Wiegand,
Michael P. Manns,
Heiner Wedemeyer,
Philippe Mathurin,
Yazdan Yazdanpanah
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
18 April 2012 |
|
Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis
DOI: 10.1016/j.jhep.2012.03.015
Background & Aims: Impairment of kidney function is common in cirrhosis but differential diagnosis remains a challenge. We aimed at assessing the usefulness of neutrophil gelatinase-associated lip...
|
Claudia Fagundes,
Marie-Noëlle Pépin,
Mónica Guevara,
Rogelio Barreto,
Gregori Casals,
Elsa Solà,
Gustavo Pereira,
Ezequiel Rodríguez,
Elisabet Garcia,
Verónica Prado,
Esteban Poch,
Wladimiro Jiménez,
Javier Fernández,
Vicente Arroyo,
Pere Ginès
et al.
|
Full-length article
(In Press Corrected Proof)
|
18 April 2012 |
|
Visceral adiposity index is not a predictor of liver histology in patients with non-alcoholic fatty liver disease
DOI: 10.1016/j.jhep.2012.03.013
Background & Aims: Visceral adiposity is associated with hepatic steatosis, inflammation, and fibrosis in non-alcoholic fatty liver disease (NAFLD). The visceral adiposity index (VAI), a novel mar...
|
Roslyn Vongsuvanh,
Jacob George,
Duncan McLeod,
David van der Poorten
|
Full-length article
(In Press Corrected Proof)
|
18 April 2012 |
|
Excessive alcohol consumption after liver transplantation impacts on long-term survival, whatever the primary indication
DOI: 10.1016/j.jhep.2012.03.014
Background & Aims: Beyond 5years, poorer survival, related to alcohol relapse, is observed in patients with liver transplant for alcohol-related liver disease (ALD). However, alcohol consumption h...
|
Stéphanie Faure,
Astrid Herrero,
Boris Jung,
Yohan Duny,
Jean-Pierre Daures,
Thibaut Mura,
Eric Assenat,
Michaël Bismuth,
Hassan Bouyabrine,
Hélène Donnadieu-Rigole,
Francis Navarro,
Samir Jaber,
Dominique Larrey,
Georges-Philippe Pageaux
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
18 April 2012 |
|
M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues
DOI: 10.1016/j.jhep.2012.03.026
Background & Aims: The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R), a multifunctional protein, plays a central role in intracellular targeting of lysosomal enzymes and c...
|
Verena Puxbaum,
Elisabeth Nimmerfall,
Christine Bäuerl,
Nicole Taub,
Pia-Maria Blaas,
Johannes Wieser,
Mario Mikula,
Wolfgang Mikulits,
Ken M. Ng,
George C.T. Yeoh,
Lukas Mach
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
18 April 2012 |
|
Reply to “Gaps in the achievement of effectiveness of HCV treatment in national VA practice”
DOI: 10.1016/j.jhep.2012.03.009
|
Bennet Cecil
|
Correspondence
(In Press Accepted Manuscript)
|
16 April 2012 |
|
Statin hepatotoxicity and the dilemma of causality in rare hepatic adverse drug reactions
DOI: 10.1016/j.jhep.2012.03.010
In his editorial, Bader highlights the problems associated with assessing statin-induced hepatotoxicity, a rare hepatic adverse drug reaction (ADR). However, the definitions of hepatotoxicity and idi...
|
Johannes Schulze,
Xaver Glass
|
Correspondence
(In Press Uncorrected Proof)
|
16 April 2012 |