Original Research

Targeting Jak/Stat pathway as a therapeutic strategy against SP/CD44+ tumorigenic cells in Akt/β-catenin-driven hepatocellular carcinoma

Tan Boon Toh, Jhin Jieh Lim, Lissa Hooi, Masturah Bte Mohd Abdul Rashid, Edward Kai-Hua Chow

DOI: https://doi.org/10.1016/j.jhep.2019.08.035

Vol. 72, Issue 1, p104–118

Stereotactic body radiation therapy vs. radiofrequency ablation in Asian patients with hepatocellular carcinoma

Nalee Kim, Jason Cheng, Inkyung Jung, Ja Der Liang, Yu Lueng Shih, Wen-Yen Huang, Tomoki Kimura, Victor H.F. Lee, Zhao Chong Zeng, Ren Zhenggan, Chul Seung Kay, Seok Jae Heo, Jong Yoon Won, Jinsil Seong

DOI: https://doi.org/10.1016/j.jhep.2020.03.005

Vol. 73, Issue 1, p121–129

Non-enhanced magnetic resonance imaging as a surveillance tool for hepatocellular carcinoma: Comparison with ultrasound

Hyo Jung Park, Hye Young Jang, So Yeon Kim, So Jung Lee, Hyung Jin Won, Jae Ho Byun, Sang Hyun Choi, Seung Soo Lee, Jihyun An, Young-Suk Lim

DOI: https://doi.org/10.1016/j.jhep.2019.12.001

Vol. 72, Issue 4, p718–724

Comparison of extracellular and hepatobiliary MR contrast agents for the diagnosis of small HCCs

Anita Paisant, Valérie Vilgrain, Jérémie Riou, Frédéric Oberti, Olivier Sutter, Valérie Laurent, Agnès Rodes, Boris Guiu, Christophe Cassinotto, Hervé Trillaud, Ivan Bricault, Sophie Michalak, Onorina Bruno, Maxime Ronot, Christophe Aubé

DOI: https://doi.org/10.1016/j.jhep.2019.12.011

Vol. 72, Issue 5, p937–945

Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p

Yu Sun, Qing Wang, Yu Zhang, Mengyuan Geng, Yujuan Wei, Yanrui Liu, Shanshan Liu, Robert B. Petersen, Junqiu Yue, Kun Huang, Ling Zheng

DOI: https://doi.org/10.1016/j.jhep.2020.03.050

Vol. 73, Issue 3, p603–615

Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis

Zhaobing Ding, Russell E. Ericksen, Nathalie Escande-Beillard, Qian Yi Lee, Abigail Loh, Simon Denil, Michael Steckel, Andrea Haegebarth, Timothy Shen Wai Ho, Pierce Chow, Han Chong Toh, Bruno Reversade, Sylvia Gruenewald, Weiping Han

DOI: https://doi.org/10.1016/j.jhep.2019.10.026

Vol. 72, Issue 4, p725–735

Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma

Robert Montal, Daniela Sia, Carla Montironi, Wei Q. Leow, Roger Esteban-Fabró, Roser Pinyol, Miguel Torres-Martin, Laia Bassaganyas, Agrin Moeini, Judit Peix, Laia Cabellos, Miho Maeda, Carlos Villacorta-Martin, Parissa Tabrizian, Leonardo Rodriguez-Carunchio, Giancarlo Castellano, Christine Sempoux, Beatriz Minguez, Timothy M. Pawlik, Ismail Labgaa, Lewis R. Roberts, Manel Sole, Maria I. Fiel, Swan Thung, Josep Fuster, Sasan Roayaie, Augusto Villanueva, Myron Schwartz, Josep M. Llovet

DOI: https://doi.org/10.1016/j.jhep.2020.03.008

Vol. 73, Issue 2, p315–327

Including mRECIST in the Metroticket 2.0 criteria improves prediction of hepatocellular carcinoma-related death after liver transplant

Alessandro Cucchetti, Matteo Serenari, Carlo Sposito, Stefano Di Sandro, Cristina Mosconi, Ilaria Vicentin, Enrico Garanzini, Vincenzo Mazzaferro, Luciano De Carlis, Rita Golfieri, Carlo Spreafico, Angelo Vanzulli, Vincenzo Buscemi, Matteo Ravaioli, Giorgio Ercolani, Antonio Daniele Pinna, Matteo Cescon

DOI: https://doi.org/10.1016/j.jhep.2020.03.018

Vol. 73, Issue 2, p342–348

BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA

Théo Z. Hirsch, Ana Negulescu, Barkha Gupta, Stefano Caruso, Bénédicte Noblet, Gabrielle Couchy, Quentin Bayard, Léa Meunier, Guillaume Morcrette, Jean-Yves Scoazec, Jean-Frédéric Blanc, Giuliana Amaddeo, Jean-Charles Nault, Paulette Bioulac-Sage, Marianne Ziol, Aurélie Beaufrère, Valérie Paradis, Julien Calderaro, Sandrine Imbeaud, Jessica Zucman-Rossi

DOI: https://doi.org/10.1016/j.jhep.2019.12.006

Vol. 72, Issue 5, p924–936

Reviews

Molecular therapies for HCC: Looking outside the box

Sandrine Faivre, Lorenza Rimassa, Richard S. Finn

DOI: https://doi.org/10.1016/j.jhep.2019.09.010

Vol. 72, Issue 2, p342–352

Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma

Ann-Lii Cheng, Chiun Hsu, Stephen L. Chan, Su-Pin Choo, Masatoshi Kudo

DOI: https://doi.org/10.1016/j.jhep.2019.09.025

Vol. 72, Issue 2, p307–319

Molecular targeted therapies: Ready for “prime time” in biliary tract cancer

Angela Lamarca, Jorge Barriuso, Mairéad G. McNamara, Juan W. Valle

DOI: https://doi.org/10.1016/j.jhep.2020.03.007

Vol. 73, Issue 1, p170–185

Reviews

Evaluation of liver tumour response by imaging

Jules Gregory, Marco Dioguardi Burgio, Giuseppe Corrias, Valérie Vilgrain, Maxime Ronot

DOI: https://doi.org/10.1016/j.jhepr.2020.100100

Vol. 2, Issue 3

Open Access

New frontiers in liver resection for hepatocellular carcinoma

Manon Allaire, Claire Goumard, Chetana Lim, Aline Le Cleach, Mathilde Wagner, Olivier Scatton

DOI: https://doi.org/10.1016/j.jhepr.2020.100134

Vol. 2, Issue 4

Open Access