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Bacterial infection in cirrhosis impairs coagulation by a heparin effect: a prospective study

      Abstract

      Background: Bacterial infections have been postulated as a trigger for variceal bleeding in cirrhotic patients, and impair coagulation evaluated by thrombelastography (TEG). Endogenous heparinoids have been detected after variceal bleeding and during liver transplantation in some cirrhotics using heparinase-modified-TEG.
      Aim: To assess if bacterial infection is associated with endogenous heparinoids in cirrhotics, thus impairing coagulation.
      Methods: Native and heparinase-modified-TEG (cleavage of heparin and heparan-sulphate) was performed in 60 cirrhotics (Grade A, 2; B, 30; C, 28): 30 infected [septicaemia, 6 (culture positive); 6 (culture negative); spontaneous bacterial peritonitis, 10; chest infection, 4; others, 4], 30 not infected, and five infected patients without liver diseases, comparing TEG parameters r, α, and ma. Eight cirrhotics were studied before and after infection. The diagnosis of presence and type of infection was based on international standard criteria.
      Results: A significant heparin effect was found only in infected cirrhotics (28 of 30) with significant changes in r (P=0.0003), α (P<0.0001), and ma (P<0.0001), but in none of those not infected. This effect completely reversed in the eight evaluated after resolution of infection. There was no heparin effect in infected non-cirrhotics.
      Conclusions: A heparin effect was only found in cirrhotic patients with infection, further confirming that infection significantly modifies coagulation in cirrhotic patients.

      Keywords

      Abbreviations:

      TEG, thrombelastography (), SBP, spontaneous bacterial peritonitis (), N-TEG, native blood thrombelastography (), HEP-TEG, heparinase-modified thrombelastography (), INR, International normalised ratio (), PT, prothrombin time (), PTT, partial thromboplastin time (), t-PA, tissue-type plasminogen activator. ()
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