Abstract
Background/Aims: To search for changes in body composition and energy metabolism associated with
the repeatedly observed weight gain of cirrhotic patients after portosystemic shunting.
Methods: Twenty-one patients were studied prospectively before and 6 and 12 months after
transjugular intrahepatic portosystemic shunt (TIPS) to assess body cell mass by two
independent methods (total body potassium counting: body cell mass determined by TBP,
BCMTBP, bioelectric impedance analysis: body cell mass determined by BIA, BCMBIA), muscle mass (anthropometry), resting energy expenditure (REECALO) by indirect calorimetry, and nutritional intake by dietary recall analysis.
Results: Prior to TIPS patients were hypermetabolic in terms of measured vs. predicted REE
(REECALO median 1423 (range 1164–1838) vs. REEPRED 1279 (1067–1687) kcal; P<0.05) and their body cell mass was lower (19.1 (10.9–33.4) vs. 31.7 (16.8–47.1) kg;
P=0.001). After TIPS body cell mass (BCMBIA) increased to 23.5 (12.7–44.3) (P<0.025) and 25.7 (14.2–39.7) kg (P=0.05) at 6 and 12 months after TIPS and this was confirmed by total potassium counting
(BCMTBP before TIPS: 18.8 (10.6–26.7) vs. 22.4 (12.9–28.5) kg at 6 months; P<0.01). Hypermetabolism persisted throughout the study period. Energy and protein
intake increased significantly by 26 and 33%.
Conclusions: An increase of prognostically relevant variables body cell and muscle mass contributes
to the weight gain after TIPS in malnourished patients with cirrhosis and hypermetabolism.
Keywords
Abbreviations:
TIPS (transjugular intrahepatic portosystemic shunt), BCM (body cell mass), BCMTBP (body cell mass determined by TBP), TBP (total body potassium), BCMBIA (body cell mass determined by BIA), BIA (bioelectrical impedance analysis), REE (resting energy expenditure), BMI (body mass index), MAMA (mid-arm muscle area), MAFA (mid-arm fat area), R (resistance), Xc (reactance), FFM (fat-free mass), TBW (total body water), TBPMEAS (total body potassium measured values), TBPPRED (total body potassium content predicted normal values), REECALO (resting energy expenditure measured by indirect calorimetry), REEPRED (resting energy expenditure predicted from regression equations of healthy controls)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
October 8,
2003
Received in revised form:
October 3,
2003
Received:
February 13,
2003
Identification
Copyright
© 2003 European Association for the Study of the Liver. Published by Elsevier Inc. All rights reserved.
