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Journal of Hepatology
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Research Article| Volume 43, ISSUE 6, P1007-1012, December 2005

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GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma

Published:June 28, 2005DOI:https://doi.org/10.1016/j.jhep.2005.05.028
GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma
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      Background/Aims

      Golgi protein-73 (GP73) is up-regulated in hepatocellular carcinoma (HCC). The aims of this study were to determine if GP73 is detected in the serum, and to establish the sensitivity and specificity of serum GP73 for diagnosing HCC.

      Methods

      Serum GP73 was detected by immunoblots and quantified by densitometric analysis.

      Results

      A total of 352 patients were studied. Serum GP73 levels were significantly higher in patients with HCC compared to those with cirrhosis (P<0.001). GP73 had a sensitivity of 69% and a specificity of 75% at the optimal cutoff point of 10 relative units, with an area under the receiver operating curve of 0.79 vs. 0.61 for AFP (P=0.001). GP73 levels had significantly higher sensitivity (62%) than AFP (25%) for diagnosing early HCC (P<0.0001). Moreover, GP73 levels were elevated in the serum of 57% (32/56) of individuals with HCC who had serum AFP levels less than 20 ng/ml.

      Conclusions

      Higher levels of GP73 can be found in the serum of patients with HCC than of those without. GP73 was better than AFP for the diagnosis of early HCC. Further validation studies are needed to confirm the role of GP73 in the early detection of HCC.

      Keywords

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      Article info

      Publication history

      Published online: June 28, 2005
      Accepted: May 8, 2005
      Received in revised form: April 19, 2005
      Received: March 8, 2005

      Identification

      DOI: https://doi.org/10.1016/j.jhep.2005.05.028

      Copyright

      © 2005 European Association for the Study of the Liver. Published by Elsevier Inc. All rights reserved.

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