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Incidence and mortality of primary sclerosing cholangitis in the UK: A population-based cohort study

  • Tim R. Card
    Correspondence
    Corresponding author. Tel.: +44 (0) 115 8230441; fax: +44 (0) 115 8230464.
    Affiliations
    University of Nottingham Medical School, Division of Epidemiology and Public Health, Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, UK

    Department of Gastroenterology, Kings Mill Hospital, Mansfield Road, Sutton, Ashfield NG17 4JT, UK
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  • Masoud Solaymani-Dodaran
    Affiliations
    University of Nottingham Medical School, Division of Epidemiology and Public Health, Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, UK
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  • Joe West
    Affiliations
    University of Nottingham Medical School, Division of Epidemiology and Public Health, Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, UK
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Published:March 31, 2008DOI:https://doi.org/10.1016/j.jhep.2008.02.017

      Background/Aims

      Little is known about the occurrence of Primary Sclerosing Cholangitis (PSC) in the population of the United Kingdom or its associated risks of mortality and malignancy. We aimed to fill these gaps in knowledge.

      Methods

      We identified 223 people with PSC and 2217 control subjects from the General Practice Research Database in the UK. We calculated incidence rates (1991–2001) and mortality rates and used Poisson and Cox regression to make comparisons between populations.

      Results

      There were 149 incident cases giving a rate of 0.41 per 100,000 person years (95% CI 0.34–0.48) and a prevalence in 2001 of 3.85 per 100,000 (95% CI 3.04 to 4.80). The incidence of PSC increased about 50% over the period studied and was higher in men compared with women. There was a three-fold mortality rate increase (Hazard ratio 2.92 (95% CI 2.16–3.94) in people with PSC compared to the general population, a two-fold increase in risk of any malignancy and a 40-fold increase in the risk of primary liver cancer (HR 2.23 and 37.44, respectively).

      Conclusions

      We believe this paper provides the most reliable estimates of the occurrence of PSC and of its risk in terms of death and malignancy in the UK available to date.

      Abbreviations:

      GPRD (General Practice Research Database), CI (confidence interval), HR (hazard ratio), SD (standard deviation), PSC (primary sclerosing cholangitis)

      Keywords

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