Editorial| Volume 63, ISSUE 5, P1064-1065, November 2015

Sedentary behaviour, physical activity, and NAFLD: Curse of the chair

  • Michael I. Trenell
    Corresponding author. Address: NIHR Senior Fellow and Professor of Metabolism & Lifestyle Medicine, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. Tel.: +44 191 208 6935.
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
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Published:August 19, 2015DOI:
      As the weight of managing non-alcoholic fatty liver disease (NAFLD) presses down upon the shoulders of our healthcare systems, there is an urgent need for effective and sustainable management strategies. Our understanding what causes and moderates NAFLD has grown considerably over the past two decades, but essentially comes down to two things; 1) energy balance [calories in and out]; and 2) a background of genetic susceptibility. As the latter is relatively fixed (excluding epigenetic effects of course), much attention is being given to exploring how calories in and out influence NAFLD. In general, eat too much and you are more likely to develop NAFLD, eat less and liver fat goes down. If you move too little you are more likely to develop NAFLD, move more and liver fat goes down. But, the devil is in the detail of course! Although there is a clear role of energy in and out in NAFLD, there appears to be a new element to this – doing nothing at all.

      Linked Article

      • Relationship of sitting time and physical activity with non-alcoholic fatty liver disease
        Journal of HepatologyVol. 63Issue 5
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          Physical activity is well-recognized to reduce the incidence and mortality of various chronic diseases, including cardiovascular disease, diabetes, stroke and several types of cancer [1–3]. More than one half of the average person’s waking day involves sedentary activities associated with prolonged sitting such as watching TV and using the computer [4]. Recently, the deleterious effects of sedentary behavior regardless of additional physical activity have received a great deal of attention [5–8].
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